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Chemical Compound Review

Pyroantimonate     antimony heptahydrate

Synonyms: AC1O3SSU, 23601-23-2, Antimonate (Sb2O74-), 38668-35-8 (dihydride), 14104-34-8 (di-K salt), ...
 
 
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Disease relevance of Pyroantimonate

  • Many neutrophilic cells from patients with myelofibrosis and myelomonocytic leukemia and from one patient in severe blast crisis had large surface deposits of pyroantimonate considered to reflect increased membrane-associated reactive cation [1].
  • Limited binding of pyroantimonate to the plasma membrane of the leukemic cell series in four patients with CML contrasted with that of the normal granulocytic cell series and the neutrophilic cells seen in myelomonocytic leukemia (two patients), myelofibrosis (one patient), and acute myelocytic leukemia (three patients) [1].
  • In liver tissue fixed with potassium pyroantimonate, more inorganic cation precipitation occurs in nucleic of hyperbasophilic foci and hepatomas than within surrounding liver parenchyma [2].
  • We have recently demonstrated microvacuolation of neurons, mitochondrial swelling (the electron microscopic correlate of microvacuolization) and massive mitochondrial calcium sequestration (using the pyroantimonate technique) following ischaemia or status epilepticus [3].
  • We present evidence for morphological changes within 15 min of injury where aggregates of pyroantimonate precipitate occur in nodal blebs at nodes of Ranvier, in focal swellings within axonal mitochondria, and at localized sites of separation of myelin lamellae [4].
 

High impact information on Pyroantimonate

 

Chemical compound and disease context of Pyroantimonate

 

Biological context of Pyroantimonate

 

Anatomical context of Pyroantimonate

 

Associations of Pyroantimonate with other chemical compounds

 

Gene context of Pyroantimonate

 

Analytical, diagnostic and therapeutic context of Pyroantimonate

References

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  4. Cytochemical evidence for redistribution of membrane pump calcium-ATPase and ecto-Ca-ATPase activity, and calcium influx in myelinated nerve fibres of the optic nerve after stretch injury. Maxwell, W.L., McCreath, B.J., Graham, D.I., Gennarelli, T.A. J. Neurocytol. (1995) [Pubmed]
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  8. Ultracytochemical calcium distribution in B cells in relation to biphasic glucose-stimulated insulin release by the perfused rat pancreas. Klöppel, G., Bommer, G. Diabetes (1979) [Pubmed]
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  17. Relation of cytoplasmic calcium to contractility in Physarum polycephalum. Kuroda, R., Kuroda, H. J. Cell. Sci. (1982) [Pubmed]
  18. Differeniated regions of human placental cell surface associated with exchange of materials between maternal and foetal blood: coated vesicles. Ockleford, C.D., Whyte, A. J. Cell. Sci. (1977) [Pubmed]
  19. Intracellular localization of calcium in the chromaffin cells of the rat adrenal medulla. Ravazzola, M. Endocrinology (1976) [Pubmed]
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  21. Evidence for extracellular localization of activator calcium in dog coronary artery smooth muscle as studied by the pyroantimonate method. Suzuki, S., Sugi, H. Cell Tissue Res. (1989) [Pubmed]
  22. Ultrastructural detection of calcium and magnesium in the chromatoid body of mouse spermatids by electron spectroscopic imaging and electron energy loss spectroscopy. Rouelle-Rossier, V.B., Biggiogera, M., Fakan, S. J. Histochem. Cytochem. (1993) [Pubmed]
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  24. Intraendothelial accumulation of calcium in the hippocampus and thalamus of rats after systemic kainic acid administration. Sztriha, L., Joo, F. Acta Neuropathol. (1986) [Pubmed]
  25. Intracellular calcium localization in stimulated, non-stimulated and repressed eccrine sweat glands. Sampson, H.W., Bowers, D.E. J. Anat. (1982) [Pubmed]
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  30. Electron microscopy and X-ray microanalyses of uterine epithelium from lead-injected mice in an experimental delay of implantation. Nilsson, B.O., Ljung, L., Wide, M. Arch. Toxicol. (1991) [Pubmed]
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