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Chemical Compound Review

HFAA     2,2,3,3,4,4,4- heptafluorobutanoyl 2,2,3,3...

Synonyms: HFBA, PubChem12579, H1006_ALDRICH, ACMC-1CNZV, AG-F-13774, ...
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Disease relevance of Heptafluorobutyric anhydride


High impact information on Heptafluorobutyric anhydride


Biological context of Heptafluorobutyric anhydride


Associations of Heptafluorobutyric anhydride with other chemical compounds


Gene context of Heptafluorobutyric anhydride

  • The specific and sensitive assay involves purification of the biological samples by solid-phase extraction with C18 cartridges, derivatization with heptafluorobutyric anhydride, and chromatography on a non-polar fused-silica capillary column [15].
  • Drugs in their free form are identified using gas chromatography/nitrogen-phosphorous detection (GC/NPD), whereas their heptafluorobutyric anhydride derivatives are detected by gas chromatography/mass spectrometry (GC/MS) in the selected ion monitoring (SIM) mode [16].
  • To quantitate mycotoxin amounts lower than 1 ppm, purified column extracts were evaporated to dryness, derivatized with heptafluorobutyric anhydride, and analyzed by gas chromatography with electron capture detection (GC-ECD) [17].
  • The method is based on the extraction of PCP and related compounds with organic solvents followed by gas chromatographic (GC) separation with nitrogen-phosphorous (NP) detection of the extract derivatized with heptafluorobutyric anhydride [18].

Analytical, diagnostic and therapeutic context of Heptafluorobutyric anhydride


  1. Electron capture gas chromatography detection and mass spectrum identification of 3-(2'-ketohexyl)indoline in spinal fluids of patients with tuberculous meningitis. Brooks, J.B., Choudhary, G., Craven, R.B., Alley, C.C., Liddle, J.A., Edman, D.C., Converse, J.D. J. Clin. Microbiol. (1977) [Pubmed]
  2. Identification of some basic extractable compounds produced by Neisseria gonorrhoeae and Neisseria meningitidis in a defined medium. Brooks, J.B., Kellogg, D.S., Choudhary, G., Alley, C.C., Liddle, J.A. J. Clin. Microbiol. (1978) [Pubmed]
  3. Disposition of metformin (N,N-dimethylbiguanide) in man. Sirtori, C.R., Franceschini, G., Galli-Kienle, M., Cighetti, G., Galli, G., Bondioli, A., Conti, F. Clin. Pharmacol. Ther. (1978) [Pubmed]
  4. Biomonitoring of workers exposed to 4,4'-methylenedianiline or 4,4'-methylenediphenyl diisocyanate. Schütze, D., Sepai, O., Lewalter, J., Miksche, L., Henschler, D., Sabbioni, G. Carcinogenesis (1995) [Pubmed]
  5. Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA). Kääriä, K., Hirvonen, A., Norppa, H., Piirilä, P., Vainio, H., Rosenberg, C. The Analyst. (2001) [Pubmed]
  6. Gas chromatographic determination and negative-ion chemical ionization mass spectrometric confirmation of 4,4'-methylenebis(2-chloroaniline) in urine via thin-layer chromatographic separation. Wu, W.S., Szklar, R.S., Smith, R. The Analyst. (1996) [Pubmed]
  7. Sensitive method for the quantitation of nortriptyline and 10-hydroxynortriptyline in human plasma by capillary gas chromatography with electron-capture detection. Anliker, S.L., Hamilton, M., Bopp, R.J., Goldberg, M.J. J. Chromatogr. (1992) [Pubmed]
  8. Quantitative determination of propildazine in rat plasma by gas-liquid chromatography. Ventura, P., Zanol, M., Visconti, M., Pifferi, G. J. Chromatogr. (1978) [Pubmed]
  9. Detection of peptaibols and their hydrolysis products in cultures of Trichoderma species. Solfrizzo, M., Altomare, C., Visconti, A., Bottalico, A., Perrone, G. Nat. Toxins (1994) [Pubmed]
  10. Determination of carbimide in plasma by gas-liquid chromatography. Loomis, C.W., Brien, J.F. J. Chromatogr. (1981) [Pubmed]
  11. Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain. Kohno, M., Ohta, S., Hirobe, M. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  12. Sensitive electron-capture gas-liquid chromatographic assay for the de-ethylated metabolite of metoclopramide. Tam, Y.K., Axelson, J.E. J. Chromatogr. (1979) [Pubmed]
  13. Gas chromatographic determination of urinary 3-methoxy-4-hydroxyphenylethyleneglycol sulphate after its ion-pair extraction. Biondi, P.A., Niu-Fan, G., Secchi, C. Clin. Chim. Acta (1982) [Pubmed]
  14. Metabolic profile of amphetamine and methamphetamine following administration of the drug famprofazone. Greenhill, B., Valtier, S., Cody, J.T. Journal of analytical toxicology. (2003) [Pubmed]
  15. Endogenous alkaloids in man. XXVI. Determination of the dopaminergic neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) in biological samples using gas chromatography with selected ion monitoring. Bringmann, G., Friedrich, H., Birner, G., Koob, M., Sontag, K.H., Heim, C., Kolasiewicz, W., Fähr, S., Stäblein, M., God, R., Feineis, D. J. Chromatogr. B, Biomed. Appl. (1996) [Pubmed]
  16. Simultaneous identification of amphetamine and methamphetamine using solid-phase extraction and gas chromatography/nitrogen phosphorous detection or gas chromatography/mass spectrometry. Taylor, R.W., Le, S.D., Philip, S., Jain, N.C. Journal of analytical toxicology. (1989) [Pubmed]
  17. Determination of the Fusarium mycotoxins nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, and 15-O-acetyl-4-deoxynivalenol in contaminated whole wheat flour by liquid chromatography with diode array detection and gas chromatography with electron capture detection. Walker, F., Meier, B. Journal of AOAC International. (1998) [Pubmed]
  18. Quantitation of phencyclidine, its metabolites, and derivatives by gas chromatography with nitrogen-phosphorus detection: application for in vivo and in vitro biotransformation studies. Holsztynska, E.J., Domino, E.F. Journal of analytical toxicology. (1986) [Pubmed]
  19. A novel method for the analysis of platelet-activating factor: direct derivatization of glycerophospholipids. Satsangi, R.K., Ludwig, J.C., Weintraub, S.T., Pinckard, R.N. J. Lipid Res. (1989) [Pubmed]
  20. Isocyanate-specific hemoglobin adduct in rats exposed to 4, 4'-methylenediphenyl diisocyanate. Sabbioni, G., Hartley, R., Henschler, D., Höllrigl-Rosta, A., Koeber, R., Schneider, S. Chem. Res. Toxicol. (2000) [Pubmed]
  21. Gas chromatographic/mass spectrometric confirmation of ten N-methylcarbamate insecticides in liver. Bakowski, R.S., Ali, M.S., White, J.D., Phillippo, E.T., Ellis, R.L. Journal of AOAC International. (1994) [Pubmed]
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