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Chemical Compound Review:

AC1OAH4V 2-(6H-indol-3-yl)ethanamine

Synonyms:

Reddy, M.V. et al., Stachów, A. et al., Heath-Pagliuso, S. et al., Asano, H. et al.

Reddy, Storer, Laws, Armstrong, Barnum, Gara, McKnight, Skopek, Sina, DeLuca, Galloway,

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Disease relevance of tryptamine

Mel, Ser, and Tryp failed to induce mutations in Salmonella and E. coli strains with or without S9 [1].
3-Methylindole (3MI), melatonin (Mel), serotonin (Ser), and tryptamine (Tryp) were evaluated in vitro for their potential to induce DNA adducts, DNA strand breaks, chromosomal aberrations (Abs), inhibition of DNA synthesis, and mutations [1].
The T/IAA ratio was normal and serotonin elevated in mild and rather severe acrosclerosis alike, i.e. in systemic scleroderma with pronounced vascular involvement [2].

High impact information on tryptamine

Not only do TA and IAA bind competitively to AhR, but they also can stimulate AhR transformation and DNA binding and induce expression of an AhR-dependent reporter gene in cells [3].
TN, or more likely N-acetyl TN, may therefore be involved in the regulation of oocyte maturation which could be a novel mechanism in oocyte maturation [4].
The T/IAA ratio and serotonin level were both elevated in a few cases of systemic scleroderma and in severe generalized morphea with concomitant vascular changes [2].

References

Genotoxicity of naturally occurring indole compounds: correlation between covalent DNA binding and other genotoxicity tests. Reddy, M.V., Storer, R.D., Laws, G.M., Armstrong, M.J., Barnum, J.E., Gara, J.P., McKnight, C.G., Skopek, T.R., Sina, J.F., DeLuca, J.G., Galloway, S.M. Environ. Mol. Mutagen. (2002) [Pubmed]
Biogenic amines derived from tryptophan in systemic and cutaneous scleroderma. Stachów, A., Jabłońska, S., Skiendzielewska, A. Acta Derm. Venereol. (1979) [Pubmed]
Activation of the Ah receptor by tryptophan and tryptophan metabolites. Heath-Pagliuso, S., Rogers, W.J., Tullis, K., Seidel, S.D., Cenijn, P.H., Brouwer, A., Denison, M.S. Biochemistry (1998) [Pubmed]
Multiple forms of arylalkylamine N-acetyltransferase (NAT) from cockroach female colleterial glands and activity changes during oocyte maturation. Asano, H., Bembenek, J., Takeda, M. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (2003) [Pubmed]

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