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Chemical Compound Review:

Tetrameen N,N,N',N'-tetramethylethane- 1,2-diamine

Synonyms: TMEDA, Temed, tmen, Propamine D, CCRIS 4870, ...

Rack, J.J. et al., Laakso, T. et al., Weigmann, H. et al., Cadée, J.A. et al., Okuda, Y. et al., et al.

Okuda, Hayashi, Sakurai, Shiotani, Rack, Rachford, Shelker,

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High impact information on Propamine D

The cyclizations are promoted by N,N,N',N'-tetramethylethylenediamine (TMEDA) [1].
We report on the spectroscopy, electrochemistry, and linkage isomerization in a family of [Ru(tpy)(L2)(dmso)](z)()(+) complexes (tpy is 2,2':6',2' '-terpyridine, dmso is dimethyl sulfoxide, and L2 is a variable ligand: 2,2'-bipyridine (bpy), 2-picolinate (pic), N,N,N',N'-tetramethylethylenediamine (tmen), acetylacetonate (acac), or malonate (mal)) [2].
PURPOSE: The oxidation of recombinant human interleukin-2 (rhlL-2) by potassium peroxodisulfate (KPS) with or without N,N,N',N'-tetramethylethylenediamine (TEMED), which are used for the preparation of dextran-based hydrogels, was investigated [3].
The complex Mn2(H2O)(OAc)4(tmeda)2 (tmeda = N,N,N',N'-tetramethylethylenediamine) is a model for the active site of hydrolase enzymes containing acetate-bridged dimanganese cores [4].
Clozapine and its metabolites were separated by HPLC on a C18 ODS Hypersil analytical column (5 microns particle size; 250 mm x 4.6 mm I.D.) using an acetonitrile-water (40:60, v/v) eluent buffered with 0.4% (v/v) N,N,N',N'-tetramethylethylenediamine and acetic acid to pH 6 [5].

Anatomical context of Propamine D

The stability of the particles, as studied both in vitro (with serum and lysosome preparations) and in vivo (via the elimination from the liver), depends on two factors, the amount of initiator of the polymerization process (N,N,N',N'-tetramethylethylenediamine, TEMED) and the degree of derivatization of the starch [6].

Associations of Propamine D with other chemical compounds

We devised a method of polyacrylamide gel electrophoresis at pH 7.3, modified by omitting base catalyst, N,N,N',N'-tetramethylethylenediamine, in the preparation of separating gels [7].
Defluorination of PTFE by alkyllithium/electron-donating solvents such as N,N,N',N'-tetramethylethylenediamine (TMEDA), hexamethylphosphoramide (HMPA) was studied by means of spectroscopy such as ESR, 7Li- and 13C-NMR, XPS, UV-Vis and IR [8].

Analytical, diagnostic and therapeutic context of Propamine D

A mechanism is proposed for background silver staining, which was found to result primarily from the redox initiator system using ammonium persulphate (APS) and an amine such as N,N,N',N'-tetramethylethylenediamine (TEMED) [9].

References

Synthesis of functionalized pyrrole and indole derivatives through carbometallation of lithiated double bonds. Fañanás, F.J., Granados, A., Sanz, R., Ignacio, J.M., Barluenga, J. Chemistry (Weinheim an der Bergstrasse, Germany) (2001) [Pubmed]
Turning off phototriggered linkage isomerizations in ruthenium dimethyl sulfoxide complexes. Rack, J.J., Rachford, A.A., Shelker, A.M. Inorganic chemistry. (2003) [Pubmed]
Oxidation of recombinant human interleukin-2 by potassium peroxodisulfate. Cadée, J.A., van Steenbergen, M.J., Versluis, C., Heck, A.J., Underberg, W.J., den Otter, W., Jiskoot, W., Hennink, W.E. Pharm. Res. (2001) [Pubmed]
An electron paramagnetic resonance study of Mn2(H2O)(OAc)4(tmeda)2 (tmeda = N,N,N',N'-tetramethylethylenediamine): a model for dinuclear manganese enzyme active sites. Howard, T., Telser, J., DeRose, V.J. Inorganic chemistry. (2000) [Pubmed]
Determination of clozapine and its major metabolites in human serum using automated solid-phase extraction and subsequent isocratic high-performance liquid chromatography with ultraviolet detection. Weigmann, H., Hiemke, C. J. Chromatogr. (1992) [Pubmed]
Biodegradable microspheres. IV: Factors affecting the distribution and degradation of polyacryl starch microparticles. Laakso, T., Artursson, P., Sjöholm, I. Journal of pharmaceutical sciences. (1986) [Pubmed]
Microheterogeneity of rat glycogen phosphorylase liver-type isozyme. Sato, T., Sato, K. Biochim. Biophys. Acta (1980) [Pubmed]
A spectroscopic study on defluorination of poly(tetrafluoroethylene) by alkyllithium/electron-donating solvents. Okuda, Y., Hayashi, F., Sakurai, H., Shiotani, M. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. (2004) [Pubmed]
On the mechanism of background silver staining during sodium dodecyl sulphate-polyacrylamide gel electrophoresis. Patras, G., Qiao, G.G., Solomon, D.H. Electrophoresis (1999) [Pubmed]

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