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Chemical Compound Review

CHEMBL6224     4-phenyl-1,2,3,6- tetrahydropyridine

Synonyms: SureCN415545, AG-D-14107, NSC-54451, CHEBI:100242, Oprea1_874761, ...
 
 
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Disease relevance of NSC 54451

 

High impact information on NSC 54451

 

Biological context of NSC 54451

 

Anatomical context of NSC 54451

 

Gene context of NSC 54451

References

  1. Central hypothermic effects of some analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridinium ion (MPP+). Satoh, N., Yonezawa, A., Tadano, T., Kisara, K., Arai, Y., Kinemuchi, H. Neurosci. Lett. (1987) [Pubmed]
  2. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as a substrate of cytochrome P450 2D6: allosteric effects of NADPH-cytochrome P450 reductase. Modi, S., Gilham, D.E., Sutcliffe, M.J., Lian, L.Y., Primrose, W.U., Wolf, C.R., Roberts, G.C. Biochemistry (1997) [Pubmed]
  3. Continuous or pulsatile chronic D2 dopamine receptor agonist (U91356A) treatment of drug-naive 4-phenyl-1,2,3,6-tetrahydropyridine monkeys differentially regulates brain D1 and D2 receptor expression: in situ hybridization histochemical analysis. Goulet, M., Morissette, M., Calon, F., Blanchet, P.J., Falardeau, P., Bédard, P.J., Di Paolo, T. Neuroscience (1997) [Pubmed]
  4. Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Chiba, K., Kubota, E., Miyakawa, T., Kato, Y., Ishizaki, T. J. Pharmacol. Exp. Ther. (1988) [Pubmed]
  5. Mapping drug-induced changes in cerebral R2* by Multiple Gradient Recalled Echo functional MRI. Chen, Q., Andersen, A.H., Zhang, Z., Ovadia, A., Gash, D.M., Avison, M.J. Magnetic resonance imaging. (1996) [Pubmed]
  6. The interactions of monoamine oxidase with some derivatives of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Sullivan, J.P., Tipton, K.F. J. Neural Transm. Suppl. (1990) [Pubmed]
  7. Molecular cloning and expression of an amine sulfotransferase cDNA: a new gene family of cytosolic sulfotransferases in mammals. Yoshinari, K., Nagata, K., Ogino, M., Fujita, K., Shiraga, T., Iwasaki, K., Hata, T., Yamazoe, Y. J. Biochem. (1998) [Pubmed]
  8. Isolation and characterization of an alicyclic amine N-sulfotransferase from female rat liver. Naritomi, Y., Niwa, T., Shiraga, T., Iwasaki, K., Noda, K. Biol. Pharm. Bull. (1994) [Pubmed]
  9. 4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors. Ishida, J., Hattori, K., Yamamoto, H., Iwashita, A., Mihara, K., Matsuoka, N. Bioorg. Med. Chem. Lett. (2005) [Pubmed]
 
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