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Chemical Compound Review

PubChem3156     4-phenylpyridine

Synonyms: TPC-I163, zlchem 480, CHEMBL109074, SureCN124353, P33429_ALDRICH, ...
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Disease relevance of NSC77935

  • The implication of this finding is that the possible application of 4-phenylpyridine in the MPTP-induced Parkinson's disease is limited by its potentiation on the neuromuscular blocking action of MPTP [1].

High impact information on NSC77935


Biological context of NSC77935


Anatomical context of NSC77935

  • This is in accord with the fact that MPP+ is rapidly concentrated in the mitochondria by an energy-dependent process, while 4-phenylpyridine seems to enter passively with the concentration gradient [5].

Associations of NSC77935 with other chemical compounds


Gene context of NSC77935


Analytical, diagnostic and therapeutic context of NSC77935


  1. Potentiation of MPTP by 4-phenylpyridine on the neuromuscular blockade in mouse phrenic nerve-diaphragm. Hsu, K.S., Lin-Shiau, S.Y. Neuropharmacology (1993) [Pubmed]
  2. L-deprenyl (selegiline) decreases excitatory synaptic transmission in the rat hippocampus via a dopaminergic mechanism. Hsu, K.S., Huang, C.C., Su, M.T., Tsai, J.J. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  3. Role of N-methyltransferases in the neurotoxicity associated with the metabolites of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and other 4-substituted pyridines present in the environment. Ansher, S.S., Cadet, J.L., Jakoby, W.B., Baker, J.K. Biochem. Pharmacol. (1986) [Pubmed]
  4. 4-phenylpyridine and three other analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lack dopaminergic nigrostriatal neurotoxicity in mice and marmosets. Perry, T.L., Jones, K., Hansen, S., Wall, R.A. Neurosci. Lett. (1987) [Pubmed]
  5. Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonism. Ramsay, R.R., Salach, J.I., Dadgar, J., Singer, T.P. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  6. Inhibition of rat brain monoamine oxidase by some analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion. Arai, Y., Kinemuchi, H., Hamamichi, N., Satoh, N., Tadano, T., Kisara, K. Neurosci. Lett. (1986) [Pubmed]
  7. Simple chip-based interfaces for on-line monitoring of supramolecular interactions by nano-ESI MS. Brivio, M., Oosterbroek, R.E., Verboom, W., van den Berg, A., Reinhoudt, D.N. Lab on a chip. (2005) [Pubmed]
  8. Autotoxicity, methylation and a road to the prevention of Parkinson's disease. Williams, A.C., Ramsden, D.B. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. (2005) [Pubmed]
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