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Chemical Compound Review:

LS-94721 N-methyl-N-[(4-tert- butylphenyl)methyl]nap...

Synonyms: C23H27N.HCl, AC1L36DO, UNII-R8XA2029ZI, Lotrimin U Ultra, Butenafine hydrochloride [USAN]

This record was replaced with 83889.

Syed, T.A. et al., Syed, T.A. et al., Iwatani, W. et al., Lesher, J.L. et al., Arika, T. et al., et al.

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Disease relevance of N-methyl-N-[(4-tert-butylphenyl)methyl]naphthalen-1-amine

Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs [1].
Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs [2].
BACKGROUND: Butenafine hydrochloride, a potent antifungal agent related to the allylamines, has been used in Japan for treating various cutaneous mycoses including tinea cruris [3].
The objective of this randomized, double-blind, placebo-controlled study was to examine the clinical efficacy and tolerability of 2% butenafine hydrochloride and 5% Melaleuca alternifolia oil incorporated in a cream to manage toenail onychomycosis in a cohort [4].
The erythema was successfully treated with topical application of butenafine hydrochloride [5].

High impact information on N-methyl-N-[(4-tert-butylphenyl)methyl]naphthalen-1-amine

The mechanism of action of a new benzylamine antimycotic, butenafine hydrochloride, was studied in Candida albicans by using the thiocarbamate antimycotic tolnaftate as a reference drug [6].

Chemical compound and disease context of N-methyl-N-[(4-tert-butylphenyl)methyl]naphthalen-1-amine

The purpose of this placebo-controlled, double-blind study was to determine the clinical efficacy, chemical avulsion, and tolerability of 2% butenafine hydrochloride and 20% urea incorporated in a cream to cure toenail onychomycosis in a preselected population [7].

References

Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs. Arika, T., Yokoo, M., Maeda, T., Amemiya, K., Yamaguchi, H. Antimicrob. Agents Chemother. (1990) [Pubmed]
Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Arika, T., Yokoo, M., Hase, T., Maeda, T., Amemiya, K., Yamaguchi, H. Antimicrob. Agents Chemother. (1990) [Pubmed]
Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial. Lesher, J.L., Babel, D.E., Stewart, D.M., Jones, T.M., Kaminester, L., Goldman, M., Weintraub, J.S. J. Am. Acad. Dermatol. (1997) [Pubmed]
Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream. Syed, T.A., Qureshi, Z.A., Ali, S.M., Ahmad, S., Ahmad, S.A. Trop. Med. Int. Health (1999) [Pubmed]
A Japanese case of tinea corporis caused by Arthroderma benhamiae. Mochizuki, T., Watanabe, S., Kawasaki, M., Tanabe, H., Ishizaki, H. J. Dermatol. (2002) [Pubmed]
Two mechanisms of butenafine action in Candida albicans. Iwatani, W., Arika, T., Yamaguchi, H. Antimicrob. Agents Chemother. (1993) [Pubmed]
Management of toenail onychomycosis with 2% butenafine and 20% urea cream: a placebo-controlled, double-blind study. Syed, T.A., Ahmadpour, O.A., Ahmad, S.A., Shamsi, S. J. Dermatol. (1998) [Pubmed]

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