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Chemical Compound Review

Genaspor     N-methyl-N-(3-methylphenyl)- 1-naphthalen-2...

Synonyms: Tinactin, Tinaderm, Tonoftal, Breezee, Micoisdin, ...
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Disease relevance of Tinaderm


High impact information on Tinaderm

  • The abnormal mitoses were associated with biochemical defects in the activation of separin, the sister-separating protease, rendering it unable to cleave the cohesin subunit Scc1 efficiently [6].
  • Separin immunoprecipitates are sufficient to cleave SCC1, indicating that separin is associated with a protease activity [7].
  • Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin [8].
  • Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast [9].
  • We show here that cleavage of Rec8 by separin at one of two different sites is necessary for the resolution of chiasmata and the disjunction of homologous chromosomes during meiosis [8].

Chemical compound and disease context of Tinaderm


Biological context of Tinaderm

  • We propose that in vertebrates, a cleavage-independent pathway removes cohesin from chromosome arms during prophase, whereas a separin-dependent pathway cleaves centromeric cohesin at the metaphase-anaphase transition [7].
  • Proteolytic cleavage of cohesin's Sccl subunit at the metaphase to anaphase transition is essential for sister chromatid separation and depends on a conserved protein called separin [9].
  • Inhibition was also demonstrated by the thiocarbamates tolciclate (IC50, 28.0 nM) and tolnaftate (IC50, 51.5 nM) [14].
  • In this review, the roles of two proteins essential for the onset of anaphase in fission yeast, Cut2/securin and Cut1/separin, are discussed with regard to cell cycle regulation, and compared with the postulated roles of homologous proteins in other organisms [15].
  • In the present study it is shown that tRNAs are involved in the up-regulation of all the cofactor-requiring RIPs up to now identified (agrostin, barley RIP, PAP and tritin, besides gelonin) [16].

Anatomical context of Tinaderm

  • Cohesin therefore has a central role in generating a dynamic tension between microtubules and sister chromatid cohesion at centromeres, which lasts until chromosome segregation is finally promoted by separin-dependent cleavage of the cohesin subunit Scc1p [17].
  • We first investigated the source of the instability of existing systems in light of endogenous ribosome-inactivating proteins and found that ribosome inactivation by tritin occurs already during extract preparation and continues during incubation for protein synthesis [18].
  • Clotrimazole, miconazole, or tolnaftate did not cause any hair cell loss in the first two turns [19].
  • We described earlier the purification and properties of a protein (tritin) from wheat that enzymatically inhibits translation in cell-free systems from animals but not plants [20].
  • We propose that the APC/separin pathway promotes close association of the centrosome with the cortex, which in turn excludes PAR-3 from the posterior pole early in a-p axis formation [21].

Associations of Tinaderm with other chemical compounds


Gene context of Tinaderm


Analytical, diagnostic and therapeutic context of Tinaderm


  1. Correlation between the activities of five ribosome-inactivating proteins in depurination of tobacco ribosomes and inhibition of tobacco mosaic virus infection. Taylor, S., Massiah, A., Lomonossoff, G., Roberts, L.M., Lord, J.M., Hartley, M. Plant J. (1994) [Pubmed]
  2. Evaluation of the effectiveness of griseofulvin, tolnaftate, and placebo in the topical therapy of superficial dermatophytoses. Zarowny, D.P., Rogers, R.S., Tindall, J.P. J. Invest. Dermatol. (1975) [Pubmed]
  3. Activity of terbinafine in experimental fungal infections of laboratory animals. Petranyi, G., Meingassner, J.G., Mieth, H. Antimicrob. Agents Chemother. (1987) [Pubmed]
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  5. Nucleotide sequence of a genomic gene encoding tritin, a ribosome-inactivating protein from Triticum aestivum. Habuka, N., Kataoka, J., Miyano, M., Tsuge, H., Ago, H., Noma, M. Plant Mol. Biol. (1993) [Pubmed]
  6. Securin is required for chromosomal stability in human cells. Jallepalli, P.V., Waizenegger, I.C., Bunz, F., Langer, S., Speicher, M.R., Peters, J.M., Kinzler, K.W., Vogelstein, B., Lengauer, C. Cell (2001) [Pubmed]
  7. Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase. Waizenegger, I.C., Hauf, S., Meinke, A., Peters, J.M. Cell (2000) [Pubmed]
  8. Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin. Buonomo, S.B., Clyne, R.K., Fuchs, J., Loidl, J., Uhlmann, F., Nasmyth, K. Cell (2000) [Pubmed]
  9. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Uhlmann, F., Wernic, D., Poupart, M.A., Koonin, E.V., Nasmyth, K. Cell (2000) [Pubmed]
  10. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Arika, T., Yokoo, M., Hase, T., Maeda, T., Amemiya, K., Yamaguchi, H. Antimicrob. Agents Chemother. (1990) [Pubmed]
  11. The treatment of dermatophytoses of the glabrous skin: a comparison of undecylenic acid and its salt versus tolnaftate. Battistini, F., Cordero, C., Urcuyo, F.G., Rojas, R.F., Ollague, W., Zaias, N. International journal of dermatology. (1983) [Pubmed]
  12. Topical treatment of dermatophytoses and candidoses. Keczkes, K., Leighton, I., Good, C.S. The Practitioner. (1975) [Pubmed]
  13. Treatment of onychomycosis by ODT therapy with 20% urea ointment and 2% tolnaftate ointment. Ishii, M., Hamada, T., Asai, Y. Dermatologica (1983) [Pubmed]
  14. Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents. Favre, B., Ryder, N.S. Antimicrob. Agents Chemother. (1996) [Pubmed]
  15. Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin. Yanagida, M. Genes Cells (2000) [Pubmed]
  16. Differential up-regulation by tRNAs of ribosome-inactivating proteins. Brigotti, M., Carnicelli, D., Alvergna, P., Pallanca, A., Sperti, S., Montanaro, L. FEBS Lett. (1995) [Pubmed]
  17. Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation. Tanaka, T., Fuchs, J., Loidl, J., Nasmyth, K. Nat. Cell Biol. (2000) [Pubmed]
  18. A highly efficient and robust cell-free protein synthesis system prepared from wheat embryos: plants apparently contain a suicide system directed at ribosomes. Madin, K., Sawasaki, T., Ogasawara, T., Endo, Y. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  19. Ototoxicity of common topical antimycotic preparations. Tom, L.W. Laryngoscope (2000) [Pubmed]
  20. Inhibitors of animal cell-free protein synthesis from grains. Coleman, W.H., Roberts, W.K. Biochim. Biophys. Acta (1982) [Pubmed]
  21. The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Rappleye, C.A., Tagawa, A., Lyczak, R., Bowerman, B., Aroian, R.V. Dev. Cell (2002) [Pubmed]
  22. Drug-induced changes in the plasma membrane of Microsporum canis. A preliminary freeze--fracture study. Puccinelli, V., Innocenti, M., Lasagni, A., Caputo, R. Br. J. Dermatol. (1977) [Pubmed]
  23. Comparison of in vitro activity of undecylenic acid and tolnaftate against athlete's foot fungi. Amsel, L.P., Cravitz, L., VanderWyk, R., Zahry, S. Journal of pharmaceutical sciences. (1979) [Pubmed]
  24. Enhancing effect of N-acetyl-l-cysteine or 2-mercaptoethanol on the in vitro permeation of 5-fluorouracil or tolnaftate through the human nail plate. Kobayashi, Y., Miyamoto, M., Sugibayashi, K., Morimoto, Y. Chem. Pharm. Bull. (1998) [Pubmed]
  25. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis. Leismann, O., Herzig, A., Heidmann, S., Lehner, C.F. Genes Dev. (2000) [Pubmed]
  26. Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast. Salah, S.M., Nasmyth, K. Chromosoma (2000) [Pubmed]
  27. Ergosterol biosynthesis inhibition: a target for antifungal agents. Barrett-Bee, K., Dixon, G. Acta Biochim. Pol. (1995) [Pubmed]
  28. Depurination of plant ribosomes by pokeweed antiviral protein. Taylor, B.E., Irvin, J.D. FEBS Lett. (1990) [Pubmed]
  29. X-ray powder diffractometric method for quantitation of crystalline drug in microparticulate systems. I. Microspheres. Dash, A.K., Khin-Khin, A., Suryanarayanan, R. Journal of pharmaceutical sciences. (2002) [Pubmed]
  30. Tolnaftate spray treatment during pregnancy. Czeizel, A.E., Kazy, Z., Puhó, E. Reprod. Toxicol. (2004) [Pubmed]
  31. Assay of tolnaftate and related impurities by isocratic supercritical fluid chromatography. Patil, S.T., Bhoir, I.C., Bhagwat, A.M., Sundaresan, M. Fresenius' journal of analytical chemistry. (2000) [Pubmed]
  32. Comparison of over-the-counter agents for tinea pedis. Tschen, E.H., Becker, L.E., Ulrich, J.A., Hoge, W.H., Smith, E.B. Cutis; cutaneous medicine for the practitioner. (1979) [Pubmed]
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