Disease relevance of Dermatomycoses

• Subsequent to entry in the randomized trial, in 92.3 patient-months without fluconazole, there were 35 episodes of thrush, one of esophagitis, one of cryptococcemia, and one of dermatophytosis, and preexisting dermatophytosis and onychomycosis were unchanged or worsened [1].
• Ketoconazole is an effective treatment for chronic superficial candidiasis as well as chronic dermatophytosis [2].
• In comparative trials, clotrimazole cream has been as effective as Whitfield's ointment and tolnaftate in the treatment of dermatophytoses, and as effective as nystatin in cutaneous candidiasis [3].
• OBJECTIVES: This study was designed to characterize the role of the human cathelicidin LL-37 in fungal skin infections such as dermatophytosis and tinea versicolor [4].
• This new imidazole derivative has been successfully administered in several cases of dermatophytosis, yeasts and pityriasis versicolor in the authors' clinic, as well as in many other research centres [5].

High impact information on Dermatomycoses

• SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses [6].
• Ketoconazole is superior to griseofulvin in the oral treatment of skin dermatophytosis [7].
• Induction by superficial (keratin) and deep (elastin) skin elements suggests that the products of these genes may be important in both superficial and deep dermatophytosis, and models for their function are proposed [8].
• The ED(50) of R126638 in a mouse dermatophytosis model was more than fivefold lower than that of itraconazole [9].
• Overall cure and improvement was observed in approximately 85 to 90% of patients with superficial dermatomycoses following treatment with amorolfine 0.25% cream for up to 6 weeks [10].

Chemical compound and disease context of Dermatomycoses

• Shorter, higher dosage itraconazole treatment regimens (200 or 400 mg/day for 1 week) are also beneficial in dermatomycoses [11].
• Naftifine. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses [12].
• Sulconazole. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses [13].
• Evaluation of the effectiveness of griseofulvin, tolnaftate, and placebo in the topical therapy of superficial dermatophytoses [14].
• The good efficacy of butenafine against dermatophytosis may be attributable to its fungicidal activity and long retention in the skin after topical application [15].

Biological context of Dermatomycoses

• Thus, the purified proteinase which has an optimal activity at acidic pH and hydrolyzes skin constituents could be an important virulence factor in dermatophytosis [16].
• Diagnosis and management of cases of suspected dermatomycosis in The Netherlands: influence of general practice based potassium hydroxide testing [17].
• A total of 719 cases of dermatophytoses was studied in the Division of Dermatology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, during January to December 1986 [18].

Anatomical context of Dermatomycoses

• The excellent therapeutic efficacy of butenafine on experimental dermatophytosis may be attributed to its low MIC and good penetration and distribution in the horny layer and hair follicles, where fungi reside [19].
• In this double-blind, placebo-controlled study, 148 patients with toenail dermatophytosis were randomized to treatment with either 250 mg terbinafine daily or placebo for 3 months [20].
• The efficacy of these compounds was evaluated with respect to direct cell-membrane damaging activity, ergosterol biosynthesis inhibition, minimum growth-inhibitory concentration (MIC) and therapeutic effect for experimental dermatophytosis of guinea pigs [21].
• IBH lesions fixed in PFA for >24 h were compared to dermatomycosis (DM) lesions; IBH biopsies contained a similar number of IgE-protein+ cells to DM biopsies (median = 249 vs. 192 cells/mm2; P = 0.08) but had significantly more IgE-mRNA+, metachromatic and tryptase+ mast cells than DM biopsies [22].
• A case of deep dermatophytosis in the gluteal region in a male patient successfully treated with terbinafine is described with its clinical, mycological and histopathological features [23].

Gene context of Dermatomycoses

• These results suggest the potential usefulness of lactoferrin as a food component for promoting dermatophytosis cure [24].
• Five patients with atopy who had chronic dermatophytosis manifested an immediate and strong trichophytin skin reaction but no delayed reaction [25].
• Dermatophytosis in lesions of disseminated superficial actinic porokeratosis [26].
• Local expression of IFN-gamma mRNA in skin lesions of patients with dermatophytosis [27].
• PCR and PCR-RFLP techniques targeting the DNA topoisomerase II gene for rapid clinical diagnosis of the etiologic agent of dermatophytosis [28].

Analytical, diagnostic and therapeutic context of Dermatomycoses

• METHODS: In this randomized, double-blind study 180 patients with fingernail dermatophytosis were treated with daily doses of either terbinafine, 250 mg/day, or microsized griseofulvin, 500 mg/day, for 12 weeks [29].
• Clinical trials have also shown significant differences favoring allylamine/benzylamine drugs over imidazoles in the treatment of dermatophytosis [30].
• Oral terbinafine in toenail dermatophytosis. A double-blind, placebo-controlled multicenter study with 12 months' follow-up [20].
• PROCEDURE: Medical records were reviewed for dogs and cats that had been treated for dermatophytosis or other fungal infections by administration of lufenuron and 18 dogs and 42 cats that were not treated and served as a control group [31].
• Earlier studies revealed that oral administration of lactoferrin (LF), a multi-functional milk protein, facilitated curing of dermatophytosis in guinea-pigs and man by an unknown mechanism [32].

References