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MeSH Review


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Disease relevance of Dermatomycoses


High impact information on Dermatomycoses


Chemical compound and disease context of Dermatomycoses


Biological context of Dermatomycoses


Anatomical context of Dermatomycoses

  • The excellent therapeutic efficacy of butenafine on experimental dermatophytosis may be attributed to its low MIC and good penetration and distribution in the horny layer and hair follicles, where fungi reside [19].
  • In this double-blind, placebo-controlled study, 148 patients with toenail dermatophytosis were randomized to treatment with either 250 mg terbinafine daily or placebo for 3 months [20].
  • The efficacy of these compounds was evaluated with respect to direct cell-membrane damaging activity, ergosterol biosynthesis inhibition, minimum growth-inhibitory concentration (MIC) and therapeutic effect for experimental dermatophytosis of guinea pigs [21].
  • IBH lesions fixed in PFA for >24 h were compared to dermatomycosis (DM) lesions; IBH biopsies contained a similar number of IgE-protein+ cells to DM biopsies (median = 249 vs. 192 cells/mm2; P = 0.08) but had significantly more IgE-mRNA+, metachromatic and tryptase+ mast cells than DM biopsies [22].
  • A case of deep dermatophytosis in the gluteal region in a male patient successfully treated with terbinafine is described with its clinical, mycological and histopathological features [23].

Gene context of Dermatomycoses


Analytical, diagnostic and therapeutic context of Dermatomycoses


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  6. Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Petranyi, G., Ryder, N.S., Stütz, A. Science (1984) [Pubmed]
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  9. In vitro and in vivo activities of the novel azole antifungal agent r126638. Odds, F., Ausma, J., Van Gerven, F., Woestenborghs, F., Meerpoel, L., Heeres, J., Vanden Bossche, H., Borgers, M. Antimicrob. Agents Chemother. (2004) [Pubmed]
  10. Amorolfine. A review of its pharmacological properties and therapeutic potential in the treatment of onychomycosis and other superficial fungal infections. Haria, M., Bryson, H.M. Drugs (1995) [Pubmed]
  11. Itraconazole. A reappraisal of its pharmacological properties and therapeutic use in the management of superficial fungal infections. Haria, M., Bryson, H.M., Goa, K.L. Drugs (1996) [Pubmed]
  12. Naftifine. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Monk, J.P., Brogden, R.N. Drugs (1991) [Pubmed]
  13. Sulconazole. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses. Benfield, P., Clissold, S.P. Drugs (1988) [Pubmed]
  14. Evaluation of the effectiveness of griseofulvin, tolnaftate, and placebo in the topical therapy of superficial dermatophytoses. Zarowny, D.P., Rogers, R.S., Tindall, J.P. J. Invest. Dermatol. (1975) [Pubmed]
  15. Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs. Arika, T., Yokoo, M., Hase, T., Maeda, T., Amemiya, K., Yamaguchi, H. Antimicrob. Agents Chemother. (1990) [Pubmed]
  16. Isolation of a keratinolytic proteinase from Trichophyton mentagrophytes with enzymatic activity at acidic pH. Tsuboi, R., Ko, I., Takamori, K., Ogawa, H. Infect. Immun. (1989) [Pubmed]
  17. Diagnosis and management of cases of suspected dermatomycosis in The Netherlands: influence of general practice based potassium hydroxide testing. De Kock, C.A., Sampers, G.H., Knottnerus, J.A. The British journal of general practice : the journal of the Royal College of General Practitioners. (1995) [Pubmed]
  18. A study of dermatophytoses in Bangkok (Thailand). Imwidthaya, S., Thianprasit, M. Mycopathologia (1988) [Pubmed]
  19. Anti-Trichophyton mentagrophytes activity and percutaneous permeation of butenafine in guinea pigs. Arika, T., Hase, T., Yokoo, M. Antimicrob. Agents Chemother. (1993) [Pubmed]
  20. Oral terbinafine in toenail dermatophytosis. A double-blind, placebo-controlled multicenter study with 12 months' follow-up. Svejgaard, E.L., Brandrup, F., Kragballe, K., Larsen, P.O., Veien, N.K., Holst, M., Andersen, B.L., Bro-Jørgensen, A.V., Dahl, J.C., Frentz, G., Graudal, C., Kamp, P., Kroman, N., Larsen, F.S., Mikkelsen, F., Munkvad, J.M., Olafsson, J.H., Rothenborg, H., Staberg, B., Søndergaard, J., Thulin, H. Acta Derm. Venereol. (1997) [Pubmed]
  21. Structure-activity relationships of a new antifungal imidazole, AFK-108, and related compounds. Hori, K., Sakaguchi, A., Kudoh, M., Ishida, K., Aoyama, Y., Yoshida, Y. Chem. Pharm. Bull. (2000) [Pubmed]
  22. Immunoglobulin-E-bearing cells in skin biopsies of horses with insect bite hypersensitivity. van der Haegen, A., Griot-Wenk, M., Welle, M., Busato, A., von Tscharner, C., Zurbriggen, A., Marti, E. Equine Vet. J. (2001) [Pubmed]
  23. Deep dermatophytosis caused by Trichophyton rubrum--a case report. Sentamilselvi, G., Janaki, C., Kamalam, A., Thambiah, A.S. Mycopathologia (1998) [Pubmed]
  24. Lactoferrin given in food facilitates dermatophytosis cure in guinea pig models. Wakabayashi, H., Uchida, K., Yamauchi, K., Teraguchi, S., Hayasawa, H., Yamaguchi, H. J. Antimicrob. Chemother. (2000) [Pubmed]
  25. Lack of delayed reaction in presence of cell-mediated immunity in trichophytin hypersensitivity. Hunziker, N., Brun, R. Archives of dermatology. (1980) [Pubmed]
  26. Dermatophytosis in lesions of disseminated superficial actinic porokeratosis. Chu, P., LeBoit, P.E. J. Am. Acad. Dermatol. (1994) [Pubmed]
  27. Local expression of IFN-gamma mRNA in skin lesions of patients with dermatophytosis. Miyata, T., Fujimura, T., Masuzawa, M., Katsuoka, K., Nishiyama, S. J. Dermatol. Sci. (1996) [Pubmed]
  28. PCR and PCR-RFLP techniques targeting the DNA topoisomerase II gene for rapid clinical diagnosis of the etiologic agent of dermatophytosis. Kamiya, A., Kikuchi, A., Tomita, Y., Kanbe, T. J. Dermatol. Sci. (2004) [Pubmed]
  29. Short-duration treatment of fingernail dermatophytosis: a randomized, double-blind study with terbinafine and griseofulvin. LAGOS III Study Group. Haneke, E., Tausch, I., Bräutigam, M., Weidinger, G., Welzel, D. J. Am. Acad. Dermatol. (1995) [Pubmed]
  30. Overview of topical therapy for common superficial fungal infections and the role of new topical agents. Brennan, B., Leyden, J.J. J. Am. Acad. Dermatol. (1997) [Pubmed]
  31. Use of lufenuron for treating fungal infections of dogs and cats: 297 cases (1997-1999). Ben-Ziony, Y., Arzi, B. J. Am. Vet. Med. Assoc. (2000) [Pubmed]
  32. Effect of lactoferrin feeding on the host antifungal response in guinea-pigs infected or immunised with Trichophyton mentagrophytes. Wakabayashi, H., Takakura, N., Yamauchi, K., Teraguchi, S., Uchida, K., Yamaguchi, H., Tamura, Y. J. Med. Microbiol. (2002) [Pubmed]
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