The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Melaleuca


High impact information on Melaleuca


Chemical compound and disease context of Melaleuca


Biological context of Melaleuca

  • Effective cooling of the burn wound and an increased rate of wound healing was achieved by both repeated tap water compresses and by immediate or delayed application of Melaleuca Hydrogel [12].

Anatomical context of Melaleuca


Associations of Melaleuca with chemical compounds

  • Individual leaves of the commercial terpinen-4-ol type of Melaleuca alternifolia were examined both quantitatively and qualitatively for volatile constituents from the emergence of the first true leaves, through to 6-week-old tenth leaf set material [16].
  • The in vitro activity of fluconazole and Melaleuca alternifolia (tea tree) oil was evaluated against 99 vaginal Candida strains by the broth microdilution and disc diffusion methods [17].
  • The antimicrobial activity of B. citriodoraessential oils was found to be greater than that of citral alone and often superior to Melaleuca alternifolia essential oil [18].
  • AIMS: The aim of this study was to analyse the antimycotic properties of Melaleuca alternifolia essential oil (tea tree oil, TTO) and its principal components and to compare them with the activity of 5-fluorocytosine and amphotericin B [19].
  • Tests on cajuput, cardamom, melissa, myrtle, niaouli and orange oil, all used at the 10% w/w concentration in propylene glycol (PG), evidenced niaouli oil (NIA) as the best permeation promoter for ES [20].

Gene context of Melaleuca


  1. Efficacy of melaleuca oral solution for the treatment of fluconazole refractory oral candidiasis in AIDS patients. Jandourek, A., Vaishampayan, J.K., Vazquez, J.A. AIDS (1998) [Pubmed]
  2. Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells. Calcabrini, A., Stringaro, A., Toccacieli, L., Meschini, S., Marra, M., Colone, M., Salvatore, G., Mondello, F., Arancia, G., Molinari, A. J. Invest. Dermatol. (2004) [Pubmed]
  3. Comparison of two topical preparations for the treatment of onychomycosis: Melaleuca alternifolia (tea tree) oil and clotrimazole. Buck, D.S., Nidorf, D.M., Addino, J.G. The Journal of family practice. (1994) [Pubmed]
  4. Role of antifungal agents in the treatment of seborrheic dermatitis. Gupta, A.K., Nicol, K., Batra, R. American journal of clinical dermatology. (2004) [Pubmed]
  5. Inhibitory effects of Indonesian medicinal plants on the infection of herpes simplex virus type 1. Nawawi, A., Nakamura, N., Hattori, M., Kurokawa, M., Shiraki, K. Phytotherapy research : PTR. (1999) [Pubmed]
  6. In vitro activities of ketoconazole, econazole, miconazole, and Melaleuca alternifolia (tea tree) oil against Malassezia species. Hammer, K.A., Carson, C.F., Riley, T.V. Antimicrob. Agents Chemother. (2000) [Pubmed]
  7. Retention time reproducibility in comprehensive two-dimensional gas chromatography using cryogenic modulation an intralaboratory study. Shellie, R.A., Xie, L.L., Marriott, P.J. Journal of chromatography. A. (2002) [Pubmed]
  8. Melaleuca oil (tea tree oil) dermatitis. Knight, T.E., Hausen, B.M. J. Am. Acad. Dermatol. (1994) [Pubmed]
  9. Evaluation of antioxidant activity of Australian tea tree (Melaleuca alternifolia) oil and its components. Kim, H.J., Chen, F., Wu, C., Wang, X., Chung, H.Y., Jin, Z. J. Agric. Food Chem. (2004) [Pubmed]
  10. Monoterpenoid accumulation in 1,8-cineole, terpinolene and terpinen-4-ol chemotypes of Melaleuca alternifolia seedlings. Russell, M.F., Southwell, I.A. Phytochemistry (2003) [Pubmed]
  11. Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream. Syed, T.A., Qureshi, Z.A., Ali, S.M., Ahmad, S., Ahmad, S.A. Trop. Med. Int. Health (1999) [Pubmed]
  12. Cooling the burn wound: evaluation of different modalites. Jandera, V., Hudson, D.A., de Wet, P.M., Innes, P.M., Rode, H. Burns : journal of the International Society for Burn Injuries. (2000) [Pubmed]
  13. Biologically active constituents of Melaleuca leucadendron: inhibitors of induced histamine release from rat mast cells. Tsuruga, T., Chun, Y.T., Ebizuka, Y., Sankawa, U. Chem. Pharm. Bull. (1991) [Pubmed]
  14. Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes. Hart, P.H., Brand, C., Carson, C.F., Riley, T.V., Prager, R.H., Finlay-Jones, J.J. Inflamm. Res. (2000) [Pubmed]
  15. Biological activity of Melaleuca alternifola (Tea Tree) oil component, terpinen-4-ol, in human myelocytic cell line HL-60. Budhiraja, S.S., Cullum, M.E., Sioutis, S.S., Evangelista, L., Habanova, S.T. Journal of manipulative and physiological therapeutics. (1999) [Pubmed]
  16. Monoterpenoid accumulation in Melaleuca alternifolia seedlings. Russell, M., Southwell, I. Phytochemistry (2002) [Pubmed]
  17. Comparison of microdilution and disc diffusion methods in assessing the in vitro activity of fluconazole and Melaleuca alternifolia (tea tree) oil against vaginal Candida isolates. Ergin, A., Arikan, S. Journal of chemotherapy (Florence, Italy) (2002) [Pubmed]
  18. Bioactivity of Backhousia citriodora: antibacterial and antifungal activity. Wilkinson, J.M., Hipwell, M., Ryan, T., Cavanagh, H.M. J. Agric. Food Chem. (2003) [Pubmed]
  19. Antimycotic activity of Melaleuca alternifolia essential oil and its major components. Oliva, B., Piccirilli, E., Ceddia, T., Pontieri, E., Aureli, P., Ferrini, A.M. Lett. Appl. Microbiol. (2003) [Pubmed]
  20. Effect of different terpene-containing essential oils on permeation of estradiol through hairless mouse skin. Monti, D., Chetoni, P., Burgalassi, S., Najarro, M., Saettone, M.F., Boldrini, E. International journal of pharmaceutics. (2002) [Pubmed]
  21. Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants. Subehan, n.u.l.l., Usia, T., Iwata, H., Kadota, S., Tezuka, Y. Journal of ethnopharmacology. (2006) [Pubmed]
  22. Can tea tree (Melaleuca alternifolia) oil prevent MRSA? Anderson, J.N., Fennessy, P.A. Med. J. Aust. (2000) [Pubmed]
  23. Inhibition of TNF-alpha promoter activity and synthesis by A11-99-1, a new cyclopentenone from the ascomycete Mollisia melaleuca. Rether, J., Erkel, G., Sterner, O., Anke, T. Z. Naturforsch., C, J. Biosci. (2005) [Pubmed]
  24. Antimicrobial activity of garlic, tea tree oil, and chlorhexidine against oral microorganisms. Groppo, F.C., Ramacciato, J.C., Simões, R.P., Flório, F.M., Sartoratto, A. International dental journal. (2002) [Pubmed]
WikiGenes - Universities