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Chemical Compound Review:

Isolane (5-methyl-2-propan-2-yl- pyrazol-3-yl) N,N...

Synonyms: ISOLAN, Saolan, HSDB 31, SureCN93443, OMS 62, ...

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Disease relevance of Isolane

We conclude that the European standard series, with exclusion of primin, is suitable for detection of allergic contact dermatitis in India. However, SQL mix is not a adequate screen for parthenium sensitivity and patch testing with extracts of the plant should be continued, wherever indicated [1].
Unusual primin dermatitis [2].
Primin as the source of sea-urchin hypersensitivity [3]?

High impact information on Isolane

Several chemical and clinical observations have suggested the presence of at least one more allergen in addition to primin in Primula obconica [4].
We believe the incidence of primula allergic contact dermatitis has fallen since the introduction of primin-free P. obconica into the European market and thus the aims of this study were twofold [5].
We conclude that the European standard series is suitable for patch testing dermatitis patients in our region, with the exception of benzocaine and primin [6].
Structure-activity relationships in allergic contact dermatitis (I). Studies on the influence of side-chain length with derivatives of primin [7].
With five of these substances (primin, mansonone A, three dalbergiones) guinea pigs could be sensitized [8].

Biological context of Isolane

The results indicate that the presence of primin and other quinones is determined by their origin and seasonal variations [9].
Primin showed very potent activity against Trypanosoma brucei rhodesiense (IC50 0.144 microM) and Leishmania donovani (IC50 0.711 microM), and revealed low cytotoxicity (IC50 15.4 microM) on mammalian cells [10].

Associations of Isolane with other chemical compounds

Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies [10].

Gene context of Isolane

Some of the chrysanthemum patients were also hypersensitive to turpentine and colophony and to garlic, primin and tars [11].

Analytical, diagnostic and therapeutic context of Isolane

The results showed a significant fall in primin-positive patch tests from 1995 to 2000 [5].

References

Common contact sensitizers in Chandigarh, India. A study of 200 patients with the European standard series. Sharma, V.K., Chakrabarti, A. Contact Derm. (1998) [Pubmed]
Unusual primin dermatitis. Virgili, A., Corazza, M. Contact Derm. (1991) [Pubmed]
Primin as the source of sea-urchin hypersensitivity? Hausen, B.M., Faasch, H., König, W.A. Contact Derm. (1987) [Pubmed]
Miconidin and miconidin methyl ether from Primula obconica Hance: new allergens in an old sensitizer. Paulsen, E., Christensen, L.P., Andersen, K.E. Contact Derm. (2006) [Pubmed]
Primula obconica--is contact allergy on the decline? Connolly, M., Mc Cune, J., Dauncey, E., Lovell, C.R. Contact Derm. (2004) [Pubmed]
Is the European standard series suitable for patch testing in Riyadh, Saudi Arabia? el-Rab, M.O., al-Sheikh, O.A. Contact Derm. (1995) [Pubmed]
Structure-activity relationships in allergic contact dermatitis (I). Studies on the influence of side-chain length with derivatives of primin. Hausen, B.M., Heitsch, H., Borrmann, B., Koch, D., Rathmann, R., Richter, B., König, W.A. Contact Derm. (1995) [Pubmed]
The sensitizing capacity of naturally occurring quinones. Experimental studies in guinea pigs. II. Benzoquinones. Schulz, K.H., Garbe, I., Hausen, B.M., Simatupang, M.H. Arch. Dermatol. Res. (1979) [Pubmed]
On the occurrence of the contact allergen primin and other quinoid compounds in species of the family of primulaceae. Hausen, B.M. Arch. Dermatol. Res. (1978) [Pubmed]
Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies. Tasdemir, D., Brun, R., Yardley, V., Franzblau, S.G., Rüedi, P. Chem. Biodivers. (2006) [Pubmed]
Contact hypersensitivity to sesquiterpene lactones in Chyrsanthemum dermatitis. Bleumink, E., Mitchell, J.C., Geismann, T.A., Towers, G.H. Contact Derm. (1976) [Pubmed]

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