Disease relevance of Veratral

• Two species, Burkholderia sp. strain VE22 and Citrobacter sp. strain VA53, were isolated by aerobic enrichment culture with veratraldehyde and vanillin, respectively [1].

High impact information on Veratral

• With this coupled reaction, for each mol of methylglyoxal, veratryl alcohol (a lignin peroxidase substrate), and oxygen consumed, 1 mol each of pyruvate and veratraldehyde is produced [2].
• ADHVI is the only S. cerevisiae enzyme able to significantly reduce veratraldehyde in vivo, and its overexpression allowed yeast to grow under toxic concentrations of this aldehyde [3].
• After 14 days, the extracellular fluid of Bjerkandera BOS55 contained 100 microM veratraldehyde and 50 microM 3-chloro-anisaldehyde [4].
• Reaction with water and hydrolysis of the hemiacetal then lead to veratraldehyde formation [5].
• The presence of RNase strongly inhibits VA oxidation to veratraldehyde by LiP; whereas the presence of VA does not inhibit RNase oxidation by LiP [6].

Biological context of Veratral

• The efficiencies of biotransformation with caffeic acid and veratraldehyde were 2.2% and 9% with respect to vanillin formation, indicating a possible diversion of the phenylpropanoid pathway towards other secondary metabolites [7].

Associations of Veratral with other chemical compounds

• The method is based on the enzymatic oxidation of veratryl alcohol to veratraldehyde by the ligninase of Phanerochaete chrysosporium [8].
• The enzyme reduced veratraldehyde to veratryl alcohol using NADPH as a cofactor [9].
• A new cyclobutane lignan, named cinbalansan (6), was isolated from the leaves of Cinnamomum balansae, along with five known compounds, 1,2-dimethoxy-4-(1-E-propenyl)benzene (1), 1,2-dimethoxy-4-(1-Z-propenyl)benzene (2), 1,2-dimethoxy-4-(2-propenyl)benzene (3), 3,4-dimethoxybenzaldehyde (4), and E-(3,4-dimethoxyphenyl)-2-propenal (5) [10].

References