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Chemical Compound Review:

SureCN2374415 1-cyclohex-3-enyl-(2-methyl- 1...

Synonyms: ANW-70780, AC1Q5JYH, LS-15399, CTK3I9376, AR-1F2834, ...

Xue, R.D. et al., Coleman, R.E. et al., Klun, J.A. et al., Frances, S.P. et al., Secor, W.E. et al., et al.

Carroll, Solberg, Klun, Kramer, Debboun, Xue, Barnard, Ali,

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Disease relevance of AI 3-37220

Acute toxicity and persistence of three insect repellents, deet and two piperidines (AI3-35765 and AI3-37220), were evaluated against mosquito larvae of Aedes albopictus (Skuse) and Anopheles albimanus Wiedemann (Diptera: Culicidae) in the laboratory, and against natural populations of Ae. albopictus in the field [1].

High impact information on AI 3-37220

Short report: prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-diethyl-3-methylbenzamide [2].
Comparative resistance of Anopheles albimanus and Aedes aegypti to N,N-diethyl-3-methylbenzamide (Deet) and 2-methylpiperidinyl-3-cyclohexen-1-carboxamide (AI3-37220) in laboratory human-volunteer repellent assays [3].
In tests with the 1S,2'S stereoisomer of AI3-37220, a newly established colony of An. albimanus from Belize bit less aggressively than El Salvador An. albimanus [3].
These topical repellents (particularly AI3-37220) have good potential for development and use in the management of container-inhabiting mosquitoes because they deter oviposition and kill larvae [1].
The repellents diethylmethylbenzamide (deet), (2-hydroxymethylcyclohexyl) acetic acid lactone (CIC-4), and 1-(3-cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220) were compared for their effectiveness in protecting 5 soldiers against the bites of Anopheles spp. at a village in Papua New Guinea [4].

Associations of AI 3-37220 with other chemical compounds

CIC-4 was more effective than deet, AI3-37220, or AI3-35765 at the ED50 but not at the ED95 level in initial sensitivity tests using human volunteers [5].
Field evaluation of deet and a piperidine repellent (AI3-37220) against Amblyomma americanum (Acari: Ixodidae) [6].
During Operation "Desert Shield," 16 volunteers field-tested four insect repellents (deet, the lactone CIC-4, and the piperidine compounds AI3-37220 and AI3-35765) against biting mosquitoes at King Fahd Airport, Eastern Province, Saudi Arabia. CIC-4 and AI3-37220 (25% wt/vol) provided effective (> 90%) protection against bites for 4 h [5].

Analytical, diagnostic and therapeutic context of AI 3-37220

In the petri dish bioassay, none of the concentrations of deet or AI3-37220 tested confined A. americanum within the treated ring [7].

References

Laboratory and field evaluation of insect repellents as larvicides against the mosquitoes Aedes albopictus and Anopheles albimanus. Xue, R.D., Barnard, D.R., Ali, A. Med. Vet. Entomol. (2001) [Pubmed]
Short report: prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-diethyl-3-methylbenzamide. Secor, W.E., Freeman, G.L., Wirtz, R.A. Am. J. Trop. Med. Hyg. (1999) [Pubmed]
Comparative resistance of Anopheles albimanus and Aedes aegypti to N,N-diethyl-3-methylbenzamide (Deet) and 2-methylpiperidinyl-3-cyclohexen-1-carboxamide (AI3-37220) in laboratory human-volunteer repellent assays. Klun, J.A., Strickman, D., Rowton, E., Williams, J., Kramer, M., Roberts, D., Debboun, M. J. Med. Entomol. (2004) [Pubmed]
Field evaluation of the repellents deet, CIC-4, and AI3-37220 against Anopheles in Lae, Papua New Guinea. Frances, S.P., Cooper, R.D., Popat, S., Sweeney, A.W. J. Am. Mosq. Control Assoc. (1999) [Pubmed]
Laboratory and field trials of four repellents with Culex pipiens (Diptera: Culicidae). Coleman, R.E., Richards, A.L., Magnon, G.J., Maxwell, C.S., Debboun, M., Klein, T.A., Wirtz, R.A. J. Med. Entomol. (1994) [Pubmed]
Field evaluation of deet and a piperidine repellent (AI3-37220) against Amblyomma americanum (Acari: Ixodidae). Solberg, V.B., Klein, T.A., McPherson, K.R., Bradford, B.A., Burge, J.R., Wirtz, R.A. J. Med. Entomol. (1995) [Pubmed]
Comparative activity of deet and AI3-37220 repellents against the ticks Ixodes scapularis and Amblyomma americanum (Acari: Ixodidae) in laboratory bioassays. Carroll, J.F., Solberg, V.B., Klun, J.A., Kramer, M., Debboun, M. J. Med. Entomol. (2004) [Pubmed]

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