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Chemical Compound Review:

SureCN907360 (2S)-2-[[(2S)-2-[[(2S)-2- amino-4...

Synonyms: AG-B-72838, AC1L3MJY, CTK7B5600, AR-1J3347, 59881-08-2, ...

Matthews, S.B. et al., Codd, E.E. et al., Kneass, Z.T. et al., Bamba, T. et al., Moser, U. et al., et al.

Mills, Miettinen, Cummings, Jesaitis,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Methionyl-leucyl-phenylalanine

Goat anti-idiotypic antibodies were further demonstrated by their ability, when absorbed to Staphylococcus aureus, to selectively bind 125I anti-f Met-Leu-Phe [1].
Chemotaxis was measured in modified Boyden chambers; chemotactic stimulants were the Formyl Met Leu Phe, Campylobacter antigen virion, and E. coli 0111 B [2].

High impact information on Methionyl-leucyl-phenylalanine

Both blood and exudate neutrophils responded chemotactically to N-formyl Met-Leu-Phe, and blood neutrophils responded chemotactically to zymosan-activated serum [3].
The highly chemotactic synthetic peptide Met-Leu-Phe was completely hydrolyzed by CFI preparations [4].
Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils [5].
Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu [6].
Effect of the chemotactic factor formyl methionyl- leucyl-phenylalanine and cytochalasin B on the cellular levels of calcium in rabbit neutrophils [7].

Biological context of Methionyl-leucyl-phenylalanine

Since neutrophil chemotaxis and oxidative metabolism are mediated by surface receptors, we studied the association of the chemotactic peptide formyl Met-Leu-Phe with neutrophils from smokers and non-smokers [8].

Anatomical context of Methionyl-leucyl-phenylalanine

METHODS: Human umbilical vein endothelial cells (HUVECs) were exposed to formylated met-leu-phe-activated PMNs [9].
N-formylated peptides being known to stimulate human granulocytes, considerably increase ascorbic acid uptake, but the non-formylated methionyl-leucyl-phenylalanine is without effect [10].
(1) We investigated the trophic effect of pectin on the intestinal mucosa injured by formyl methionyl-leucyl-phenylalanine (FMLP), a chemoattractant produced by the intestinal bacterial flora [11].

Associations of Methionyl-leucyl-phenylalanine with other chemical compounds

Polymorphonuclear leukocytes activated by latex (polystyrene) beads or the chemotactic peptide N-formyl Met Leu Phe stimulated the oxidation of adrenaline (0.3 microM-10 mM) to adrenochrome, detected spectrophotometrically at 480 nm or by a high-performance liquid chromatographic (HPLC) method [12].

Gene context of Methionyl-leucyl-phenylalanine

Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates f Met-Leu-Phe receptors on human neutrophils [13].

Analytical, diagnostic and therapeutic context of Methionyl-leucyl-phenylalanine

Formylated Met-Leu-Phe (fMLF) is shown to stimulate a rapid and transient increase in protein O-GlcNAcylation in both immunoblot and immunofluorescence imaging assays using O-GlcNAc-specific antibodies [14].

References

Anti-idiotype as antibody against the formyl peptide chemotaxis receptor of the neutrophil. Marasco, W.A., Becker, E.L. J. Immunol. (1982) [Pubmed]
The immune system response to Campylobacter infection. Melamed, A., Zakuth, V., Schwartz, D., Spirer, Z. Microbiol. Immunol. (1988) [Pubmed]
Failure of rabbit neutrophils to secrete endogenous pyrogen when stimulated with staphylococci. Hanson, D.F., Murphy, P.A., Windle, B.E. J. Exp. Med. (1980) [Pubmed]
Characterization of the protease activity in the chemotactic factor inactivator. Ward, P.A., Ozols, J. J. Clin. Invest. (1976) [Pubmed]
Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils. Frasch, S.C., Henson, P.M., Nagaosa, K., Fessler, M.B., Borregaard, N., Bratton, D.L. J. Biol. Chem. (2004) [Pubmed]
Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. Mills, J.S., Miettinen, H.M., Cummings, D., Jesaitis, A.J. J. Biol. Chem. (2000) [Pubmed]
Effect of the chemotactic factor formyl methionyl- leucyl-phenylalanine and cytochalasin B on the cellular levels of calcium in rabbit neutrophils. Petroski, R.J., Naccache, P.H., Becker, E.L., Sha'afi, R.I. FEBS Lett. (1979) [Pubmed]
Altered chemotactic peptide binding in tobacco smokers' neutrophils. Codd, E.E., Bridges, R.B. Regul. Pept. (1986) [Pubmed]
Loss of endothelial barrier function requires neutrophil adhesion. Marcus, B.C., Hynes, K.L., Gewertz, B.L. Surgery (1997) [Pubmed]
Uptake of ascorbic acid by human granulocytes. Moser, U., Weber, F. International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition. (1984) [Pubmed]
Effect of pectin on formyl methionyl-leucyl-phenylalanine (FMLP)-injured intestinal mucosa of rat. Bamba, T., Chun, W., Nakajo, S., Hosoda, S. J. Nutr. Sci. Vitaminol. (1992) [Pubmed]
The adrenochrome pathway. A potential catabolic route for adrenaline metabolism in inflammatory disease. Matthews, S.B., Hallett, M.B., Henderson, A.H., Campbell, A.K. Advances in myocardiology. (1985) [Pubmed]
Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates f Met-Leu-Phe receptors on human neutrophils. Atkinson, Y.H., Lopez, A.F., Marasco, W.A., Lucas, C.M., Wong, G.G., Burns, G.F., Vadas, M.A. Immunology (1988) [Pubmed]
Neutrophils exhibit rapid agonist-induced increases in protein-associated O-GlcNAc. Kneass, Z.T., Marchase, R.B. J. Biol. Chem. (2004) [Pubmed]

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