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Chemical Compound Review

Adrenochrome     3-hydroxy-1-methyl-2,3- dihydroindole-5,6...

Synonyms: Adraxone, SureCN61927, SureCN61928, AG-F-86739, A5752_SIGMA, ...
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Disease relevance of Adrenochrome


High impact information on Adrenochrome


Chemical compound and disease context of Adrenochrome


Biological context of Adrenochrome


Anatomical context of Adrenochrome


Associations of Adrenochrome with other chemical compounds


Gene context of Adrenochrome


Analytical, diagnostic and therapeutic context of Adrenochrome


  1. Leukocyte response in patients suffering from acute stroke. Violi, F., Rasura, M., Alessandri, C., Intiso, D., Germani, M., Servi, M., Fieschi, C., Balsano, F. Stroke (1988) [Pubmed]
  2. Differential action on cancer and normal tissue by adrenochrome monoaminoguanidine methanesulfonate and cytochrome C combined with radiotherapy. Nakatsugawa, S., Sugahara, T. Int. J. Radiat. Oncol. Biol. Phys. (1994) [Pubmed]
  3. Protective effect of sulfinpyrazone against catecholamine metabolite adrenochrome-induced arrhythmias. Beamish, R.E., Dhillon, K.S., Singal, P.K., Dhalla, N.S. Am. Heart J. (1981) [Pubmed]
  4. Metabolic arrest of the ischemic heart. Tyers, G.F. Ann. Thorac. Surg. (1975) [Pubmed]
  5. Does captopril attenuate reperfusion-induced myocardial dysfunction by scavenging free radicals? Westlin, W., Mullane, K. Circulation (1988) [Pubmed]
  6. Oxidation of epinephrine by a cell-free system from human granulocytes. Babior, B.M., Kipnes, R.S. Blood (1976) [Pubmed]
  7. Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes. Baez, S., Segura-Aguilar, J., Widersten, M., Johansson, A.S., Mannervik, B. Biochem. J. (1997) [Pubmed]
  8. The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome p450-mediated metabolism of xenobiotics. Chen, C., Thakker, D.R. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  9. An unusual NAD(P)H-dependent O2-.-enerating redox system in hepatoma 22a nuclei. Peskin, A.V., Konstantinov, A.A., Zbarsky, I.B. Free Radic. Res. Commun. (1987) [Pubmed]
  10. Inhibition of kidney cortex gluconeogenesis by adrenochrome and indile 2-carboxylic acid. Hems, D.A., Rodrigues, L.M. Biochem. Pharmacol. (1976) [Pubmed]
  11. Ventricular dysfunction and necrosis produced by adrenochrome metabolite of epinephrine: relation to pathogenesis of catecholamine cardiomyopathy. Yates, J.C., Beamish, R.E., Dhalla, N.S. Am. Heart J. (1981) [Pubmed]
  12. Effect of adrenochrome on adenine nucleotides and mitochondrial oxidative phosphorylation in rat heart. Taam, G.M., Takeo, S., Ziegelhoffer, A., Singal, P.K., Beamish, R.E., Dhalla, N.S. The Canadian journal of cardiology. (1986) [Pubmed]
  13. Cardiotoxicity of adrenochrome in isolated rabbit hearts assessed by epicardial NADH fluorescence. Rump, A.F., Klaus, W. Arch. Toxicol. (1994) [Pubmed]
  14. Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. Takeo, S., Taam, G.M., Beamish, R.E., Dhalla, N.S. J. Pharmacol. Exp. Ther. (1980) [Pubmed]
  15. Effect of adrenochrome on calcium accumulation by heart mitochondria. Takeo, S., Taam, G.M., Beamish, R.E., Dhalla, N.S. Biochem. Pharmacol. (1981) [Pubmed]
  16. Adrenochrome-induced coronary artery constriction in the rat heart. Karmazyn, M., Beamish, R.E., Fliegel, L., Dhalla, N.S. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  17. Catalysis of nitrofuran redox-cycling and superoxide anion production by heart lipoamide dehydrogenase. Sreider, C.M., Grinblat, L., Stoppani, A.O. Biochem. Pharmacol. (1990) [Pubmed]
  18. Captopril and enalaprilat do not scavenge the superoxide anion. Kukreja, R.C., Kontos, H.A., Hess, M.L. Am. J. Cardiol. (1990) [Pubmed]
  19. Effects of superoxide dismutase and catalase during reduction of adrenochrome by DT-diaphorase and NADPH-cytochrome P450 reductase. Baez, S., Segura-Aguilar, J. Biochem. Mol. Med. (1995) [Pubmed]
  20. The adrenochrome pathway. A potential catabolic route for adrenaline metabolism in inflammatory disease. Matthews, S.B., Hallett, M.B., Henderson, A.H., Campbell, A.K. Advances in myocardiology. (1985) [Pubmed]
  21. Modification of adrenochrome-induced cardiac contractile failure and cell damage by changes in cation concentrations. Yates, J.C., Taam, G.M., Singal, P.K., Beamish, R.E., Dhalla, N.S. Lab. Invest. (1980) [Pubmed]
  22. The effect of oxidized isoprenaline on the chick embryonic heart. Janatová, T., Pelouch, V., Ostádal, B., Krause, E.G. Can. J. Physiol. Pharmacol. (1986) [Pubmed]
  23. HSV-induced reactivation: contribution of epinephrine after corneal iontophoresis. Dunkel, E.C., Pavan-Langston, D. Curr. Eye Res. (1987) [Pubmed]
  24. Partial characterization of the 1-anilino-8-naphthalene sulfonate-adrenochrome semicarbazide interaction site in erythrocyte ghost membrane fragments. Millar, D.B. Biophys. Chem. (1975) [Pubmed]
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