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Chemical Compound Review

Mandate     methyl2-(difluoromethyl)-5- (4,5-dihydro-1...

Synonyms: Thiazopyr, Thiazophyr, Visor, SureCN53467, AG-D-92017, ...
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Disease relevance of Thiazopyr

  • Increased levels of serum TSH, T3, and rT3, decreased levels of T4, and an increased incidence of thyroid follicular cell hypertrophy and hyperplasia were observed 56 days after the initiation of 3000 ppm thiazopyr [1].
  • The sustained increase in TSH by thiazopyr appears responsible for the stimulation of the thyroid follicular cells resulting in follicular cell hypertrophy, hyperplasia, and ultimately neoplasia [1].

Psychiatry related information on Thiazopyr

  • To compensate for the uncertainty inherent in financial decision making and alleviate the problem of information clutter, trustees can take three steps to ensure that their decisions promote the organization's well-being: Mandate a minimum standard of performance [2].

High impact information on Thiazopyr


Biological context of Thiazopyr


Anatomical context of Thiazopyr


Associations of Thiazopyr with other chemical compounds


  1. Mechanism of thiazopyr-induced effects on thyroid hormone homeostasis in male Sprague-Dawley rats. Hotz, K.J., Wilson, A.G., Thake, D.C., Roloff, M.V., Capen, C.C., Kronenberg, J.M., Brewster, D.W. Toxicol. Appl. Pharmacol. (1997) [Pubmed]
  2. Trustees' role in financial decisions. Choate, G.M. Health progress (Saint Louis, Mo.) (1987) [Pubmed]
  3. Thiazopyr and Thyroid Disruption: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action. Dellarco, V.L., McGregor, D., Berry, S.C., Cohen, S.M., Boobis, A.R. Crit. Rev. Toxicol. (2006) [Pubmed]
  4. Metabolic deactivation of the herbicide thiazopyr by animal liver esterases. Feng, P.C., Ruff, T.G., Kosinski, W.G. Xenobiotica (1995) [Pubmed]
  5. In vitro biotransformation of thiazopyr by rat liver microsomes: oxidative cleavage of a carboxylic methylester by monooxygenases. Feng, P.C., Solsten, R.T. Xenobiotica (1994) [Pubmed]
  6. Infective diseases in Israel. Changing patterns over 30 years. Yekutiel, P. Isr. J. Med. Sci. (1979) [Pubmed]
  7. The future of child psychiatry. Mandate for change. McConville, B.J. Canadian Psychiatric Association journal. (1975) [Pubmed]
  8. Sexual harassment complaints. Mandate from the Board of Medical Examiners. Kern, S.I., Alessi, D.J. New Jersey medicine : the journal of the Medical Society of New Jersey. (2003) [Pubmed]
  9. Adsorption and degradation of thiazopyr in compost-amended and non-amended soils. Fernández, M.D., Sánchez-Brunete, C., Rodríguez, A.J., Tadeo, J.L. Pest Manag. Sci. (2001) [Pubmed]
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