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Chemical Compound Review:

Albizziin (2S)-2-amino-3- (aminocarbonylamino)propano...

Synonyms: Albizzine, L-Albizziin, L-Albizziine, AG-D-93836, AG-L-65895, ...

Andrulis, I.L. et al., Wei, C. et al., Ray, P.N. et al., Andrulis, I.L. et al., Freikopf, A. et al., et al.

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Disease relevance of C08264

Human cell lines resistant to L-asparaginase or albizziin were isolated by multistep selection of HT1080 fibrosarcoma and MIA PaCa-2 pancreatic carcinoma cells [1].

High impact information on C08264

Albizziin-resistant cell lines, which had amplified copies of the gene, were extensively demethylated in the 5' region [2].
These results suggest that resistance to albizziin in the multistep lines may be due to gene amplification [3].
Chromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells [3].
The multistep albizziin-resistant cell lines usually had expanded chromosomal regions which stained somewhat homogeneously, often on the long arm of chromosome 1 [3].
In previous reports we have described the isolation and characterization of a number of Chinese hamster ovary (CHO) cell mutants resistant to the amino acid analogue albizziin (Alb) [4].

Biological context of C08264

Overexpression of asparagine synthetase in albizziin-resistant murine diploid embryonic stem cells [5].

Associations of C08264 with other chemical compounds

We had previously found that Chinese hamster ovary (CHO) and human cell lines selected in albizziin (Alb), an amino acid analog of L-glutamine, overexpress asparagine synthetase (AS) due to gene amplification [5].

Gene context of C08264

Diazo-oxonorleucine and albizzine inhibited neither the transferase nor the synthetase activity of glutamine synthetase [6].

References

Molecular and genetic characterization of human cell lines resistant to L-asparaginase and albizziin. Andrulis, I.L., Argonza, R., Cairney, A.E. Somat. Cell Mol. Genet. (1990) [Pubmed]
DNA methylation patterns associated with asparagine synthetase expression in asparagine-overproducing and -auxotrophic cells. Andrulis, I.L., Barrett, M.T. Mol. Cell. Biol. (1989) [Pubmed]
Chromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells. Andrulis, I.L., Duff, C., Evans-Blackler, S., Worton, R., Siminovitch, L. Mol. Cell. Biol. (1983) [Pubmed]
Molecular cloning of a cDNA for Chinese hamster ovary asparagine synthetase. Ray, P.N., Siminovitch, L., Andrulis, I.L. Gene (1984) [Pubmed]
Overexpression of asparagine synthetase in albizziin-resistant murine diploid embryonic stem cells. Wei, C., Andrulis, I.L. Somat. Cell Mol. Genet. (1993) [Pubmed]
Specificity of the glutamine-binding site involved in the reguation of glutamine-synthetase activity in hepatoma tissue-culture cells. Freikopf, A., Kulka, R.G. Eur. J. Biochem. (1975) [Pubmed]

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