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Chemical Compound Review

AmbotzHAA6180     (2S)-2,5-dihydro-1H-pyrrole- 2-carboxylic acid

Synonyms: PubChem13924, CHEMBL78920, AG-F-43385, SureCN1021492, D4893_SIGMA, ...
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Disease relevance of BRN 5376764

  • L-3,4-dehydroproline produces nodules with a mean diameter of 2.3 +/- 0.5 cm and mean collagen content of 12 +/- 2 mg/g with a 40% incidence of metastasis [1].
  • The animals who were injected subcutaneously with B16 melanoma and treated with L 3,4-dehydroproline (an inhibitor of collagen synthesis) local tumor growth was significantly enhanced only for the old animals [2].
  • In this study we devised alternative methods to enumerate intracellular Salmonellae using a lytic bacteriophage, SP6, and an amino acid auxotroph, Pro- mutant, which replicates selectively within host cells in the presence of its uptake inhibitor, 3,4-dehydro-L-proline [3].

High impact information on BRN 5376764


Analytical, diagnostic and therapeutic context of BRN 5376764


  1. Increased invasion and spontaneous metastasis of BL6 melanoma with inhibition of the desmoplastic response in C57 BL/6 mice. Barsky, S.H., Gopalakrishna, R. Cancer Res. (1987) [Pubmed]
  2. Experimental tumors and aging: local factors that may account for the observed age advantage in the B16 murine melanoma model. Ershler, W.B., Gamelli, R.L., Moore, A.L., Hacker, M.P., Blow, A.J. Exp. Gerontol. (1984) [Pubmed]
  3. Alternative methods to limit extracellular bacterial activity for enumeration of intracellular bacteria. Kim, H.J., Kim, E.Y., Hong, Y., Rhee, J.H., Choy, H.E. J. Microbiol. Methods (2006) [Pubmed]
  4. 3,4-Dehydroproline inhibits cell wall assembly and cell division in tobacco protoplasts. Cooper, J.B., Heuser, J.E., Varner, J.E. Plant Physiol. (1994) [Pubmed]
  5. Induction of endothelial cell migration by proline analogs and its relevance to angiogenesis. McAuslan, B.R., Reilly, W., Hannan, G.N., Schindhelm, K., Milthorpe, B., Saur, B.A. Exp. Cell Res. (1988) [Pubmed]
  6. Pharmacological effects of introducing a double bond into a binding site of oxytocin. Analogues with L-3,4-dehydroproline in position 7. Moore, S., Felix, A.M., Meienhofer, J., Smith, C.W., Walter, R. J. Med. Chem. (1977) [Pubmed]
  7. Studies on the effect of L-3,4-dehydroproline on collagen synthesis by chick embryo polysomes. Kerwar, S.S., Marcel, R.J., Salvador, R.A. Arch. Biochem. Biophys. (1976) [Pubmed]
  8. Biochemical and ultrastructural study of the effects of proline analogues on collagen synthesis in 3T6 fibroblasts. Carrington, M.J., Fornieri, C., Bartlet, C.P., Heale, G., Levene, C.I. J. Pharm. Pharmacol. (1985) [Pubmed]
  9. Effect of L-3,4-dehydroproline on collagen synthesis and prolyl hydroxylase activity in mammalian cell cultures. Kerwar, S.S., Felix, A.M. J. Biol. Chem. (1976) [Pubmed]
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