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Chemical Compound Review:

PubChem18879 1,2,3,4,5,6-hexafluorobenzene

Synonyms: H8706_ALDRICH, ACMC-1BMUS, AG-K-69534, CHEBI:38589, ANW-29049, ...

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Disease relevance of HEXAFLUOROBENZENE

Comparative biotransformation of hexachlorobenzene and hexafluorobenzene in relation to the induction of porphyria [1].

High impact information on HEXAFLUOROBENZENE

Complete negative ion gas chromatography/mass spectrometry (GC/MS) spectra were obtained for hexafluorobenzene and TNT by simultaneously ramping the electron energy from -2 to 15 eV and scanning the mass over a 200-Da range [2].
Shape-persistent macrocycle with a self-complementary recognition pattern based on diacetylene-linked alternating hexylbenzene and perfluorobenzene rings [3].
Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility [4].
By employing hexafluorobenzene to react with Na incorporated within the channels (diameter 200 nm) of anodized aluminum oxide (AAO) membranes at 323-623 K, the carbon material can be fabricated into aligned porous nanotube arrays (ca. 250 nm in diameter, ca. 20 nm in wall thickness, ca. 0.06 mm in length, and ca. 3-90 nm in pore diameter) [5].
We recently established a novel magnetic resonance in vivo approach to measuring regional tumor oxygen tension, FREDOM (Fluorocarbon Relaxometry Using Echo Planar Imaging for Dynamic Oxygen Mapping), using hexafluorobenzene (HFB) as the reporter molecule [6].

Analytical, diagnostic and therapeutic context of HEXAFLUOROBENZENE

19F NMR was employed to observe hexafluorobenzene binding and to monitor titrations with competing hydrophobic and polar ligands similar in size and shape to hexafluorobenzene [7].
The development of an injectable probe formulation, consisting of perchlorotriphenylmethyl triester radical dissolved in hexafluorobenzene, for in vivo oximetry and imaging of oxygen concentration in tissues using electron paramagnetic resonance (EPR) imaging is reported [8].
METHODS AND MATERIALS: Regional tumor oxygen tension was measured using 19F nuclear magnetic resonance echo planar imaging relaxometry of hexafluorobenzene, which provided dynamic maps with respect to respiratory intervention [9].

References

Comparative biotransformation of hexachlorobenzene and hexafluorobenzene in relation to the induction of porphyria. Rietjens, I.M., Steensma, A., Den Besten, C., van Tintelen, G., Haas, J., van Ommen, B., van Bladeren, P.J. Eur. J. Pharmacol. (1995) [Pubmed]
Capillary gas chromatographic introduction of environmental compounds into a trochoidal electron monochromator/mass spectrometer. Laramée, J.A., Deinzer, M.L. Anal. Chem. (1994) [Pubmed]
Shape-persistent macrocycle with a self-complementary recognition pattern based on diacetylene-linked alternating hexylbenzene and perfluorobenzene rings. Shu, L., Mayor, M. Chem. Commun. (Camb.) (2006) [Pubmed]
Hexafluorobenzene acts in the spinal cord, whereas o-difluorobenzene acts in both brain and spinal cord, to produce immobility. Antognini, J.F., Raines, D.E., Solt, K., Barter, L.S., Atherley, R.J., Bravo, E., Laster, M.J., Jankowska, K., Eger, E.I. Anesth. Analg. (2007) [Pubmed]
Formation of porous carbon materials with in situ generated NaF nanotemplate. Huang, C.H., Chang, Y.H., Wang, H.W., Cheng, S., Lee, C.Y., Chiu, H.T. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2006) [Pubmed]
Tumor oxygen dynamics: correlation of in vivo MRI with histological findings. Zhao, D., Ran, S., Constantinescu, A., Hahn, E.W., Mason, R.P. Neoplasia (2003) [Pubmed]
Design of a functional protein for molecular recognition: specificity of ligand binding in a metal-assembled protein cavity probed by 19f NMR. Doerr, A.J., Case, M.A., Pelczer, I., McLendon, G.L. J. Am. Chem. Soc. (2004) [Pubmed]
A highly sensitive biocompatible spin probe for imaging of oxygen concentration in tissues. Bratasz, A., Kulkarni, A.C., Kuppusamy, P. Biophys. J. (2007) [Pubmed]
Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (MAT-Lu and HI) with respect to growth and respiratory challenge. Zhao, D., Constantinescu, A., Hahn, E.W., Mason, R.P. Int. J. Radiat. Oncol. Biol. Phys. (2002) [Pubmed]

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