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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Oximetry


High impact information on Oximetry

  • Using a combination of enzyme oximetry, pulse radiolysis, and chemical oxidation, the study of structurally modified dopaquinones provides firm evidence of nonenzymatic catechol formation during tyrosinase oxidation of phenols and reveals significant differences in their modes of reaction [6].
  • Left-to-right shunt (by oximetry in 16 of 17 patients) was 2.4 to 16.2 L/min, and the Qp/QS ratio was 1.4 to 4 [7].
  • Lithium phthalocyanine: a probe for electron paramagnetic resonance oximetry in viable biological systems [8].
  • Among the 33 patients recatheterized at 6 months, oximetry had detected AS in 10, and dilution curves detected AS in an additional nine (total, 58%) immediately after PMV [9].
  • MC 540-mediated photooxidation of histidine, arachidonate, and unsaturated phospholipid vesicles was assessed by spin label oximetry and shown to involve type II (singlet oxygen) chemistry [10].

Chemical compound and disease context of Oximetry


Biological context of Oximetry

  • Progress of lipid peroxidation, induced by aerobic photoexcitation of rose bengal, was monitored by the detection of lipid hydroperoxides and by electron spin resonance oximetry [16].
  • This work broadens the scope and improves the time resolution of spin-probe oximetry, a technique in which small nitroxide spin probes detect oxygen consumption via change in their relaxation properties [Froncisz, W., Lai, C.-S., & Hyde, J. S. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 411-415] [17].
  • A detailed study of the kinetics of iron(II) oxidation by molecular oxygen in natural and recombinant human apoferritins has been carried out using electrode oximetry to better understand the ferroxidase activity of the protein shell [18].
  • Variables monitored during these 5-min periods included heart rate, respiratory rate, mean arterial pressure, mean airway pressure (Paw), end-tidal CO2 (PetCO2), pulse oximetry oxygen saturation, PaO2, and PaCO2 [19].
  • Blood pressure, heart rate, hemoglobin oxygen saturation via finger pulse oximetry, and ventilatory and occlusion pressure responses to CO2 were obtained before and 20, 40, 60, 90, 120, 180, 240, 300, and 360 min after administration of drug or drug combination [20].

Anatomical context of Oximetry


Associations of Oximetry with chemical compounds

  • During FOB and the 30 min thereafter, pulse oximetry values (Sp(O(2))) were significantly higher in the CPAP than the Oxygen group (95.7 +/- 1.9% versus 92.6 +/- 3.1, p = 0.02) [26].
  • Ventilation was compared in the two groups by continuous pulse oximetry, by venous blood gases on postoperative day 1 (POD 1) and by CO2 response curves [27].
  • Blood glucose levels were determined by oximetry before and 30, 60, and 120 min after the glucose administration [28].
  • To correct for damping of the S state synchronization during the flash sequence, the Kok parameters were estimated by measuring the oxygen flash pattern in situ using nitroxide-based EPR oximetry [29].
  • Oxygen consumption by tyrosinase during oxidation of the monohydric phenol substrates tyrosine and 4-hydroxyanisole (4HA) was monitored by oximetry in order to determine the stoichiometry of the reactions [30].

Gene context of Oximetry

  • All patients were monitored with EKG, NIBP and pulse oximetry (SPO2) during the operation [31].
  • Combined with continuous pulse oximetry they can be used as an alternative to arterial blood gas measurements in patients with acute exacerbations of COPD [32].
  • In 16 patients with an atrial septal defect, the Qp/Qs ration measured by oximetry ranged from 1.34 to 4.61 and by pulsed Doppler echocardiography from 1.31 to 4.46 (p = NS) [33].
  • CONCLUSIONS--The BTS pulse oximetry criteria are highly specific when positive (specificity = 100%), but may miss patients with the SAHS who have hypopnoeic episodes which cause arousal but not significant oxygen desaturation (sensitivity = 31%) [34].
  • Total hospitalization respiratory care costs for COPD patients were higher, $4,064 ($2,422-$9,572) vs. $2,342 ($1,186-$4,591), (p = .0001), and 74.4% of the median difference in cost between COPD patients and others was accounted for by spontaneous nebulizers (p = .001), metered dose inhalers (p = .01), and pulse oximetry (p = .02) [35].

Analytical, diagnostic and therapeutic context of Oximetry


  1. Magnesium sulfate in exacerbations of chronic obstructive pulmonary disease. Skorodin, M.S., Tenholder, M.F., Yetter, B., Owen, K.A., Waller, R.F., Khandelwahl, S., Maki, K., Rohail, T., D'Alfonso, N. Arch. Intern. Med. (1995) [Pubmed]
  2. The dose response of theophylline in the treatment of apnea of prematurity. Muttitt, S.C., Tierney, A.J., Finer, N.N. J. Pediatr. (1988) [Pubmed]
  3. Dapsone-induced methemoglobinemia and pulse oximetry. Trillo, R.A., Aukburg, S. Anesthesiology (1992) [Pubmed]
  4. Clinical experience with cerebral oximetry in stroke and cardiac arrest. Nemoto, E.M., Yonas, H., Kassam, A. Crit. Care Med. (2000) [Pubmed]
  5. Routine pulse oximetry during methacholine challenges is unnecessary for safety. Cockcroft, D.W., Hurst, T.S., Marciniuk, D.D., Cotton, D.J., Laframboise, K.F., Nagpal, A.K., Skomro, R.P. Chest (2000) [Pubmed]
  6. Tyrosinase autoactivation and the chemistry of ortho-quinone amines. Land, E.J., Ramsden, C.A., Riley, P.A. Acc. Chem. Res. (2003) [Pubmed]
  7. Quantitative analysis of the morphology of secundum-type atrial septal defects and their dynamic change using transesophageal three-dimensional echocardiography. Franke, A., Kühl, H.P., Rulands, D., Jansen, C., Erena, C., Grabitz, R.G., Däbritz, S., Messmer, B.J., Flachskampf, F.A., Hanrath, P. Circulation (1997) [Pubmed]
  8. Lithium phthalocyanine: a probe for electron paramagnetic resonance oximetry in viable biological systems. Liu, K.J., Gast, P., Moussavi, M., Norby, S.W., Vahidi, N., Walczak, T., Wu, M., Swartz, H.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  9. Left-to-right atrial shunting after percutaneous mitral valvuloplasty. Incidence and long-term hemodynamic follow-up. Cequier, A., Bonan, R., Serra, A., Dyrda, I., Crépeau, J., Dethy, M., Waters, D. Circulation (1990) [Pubmed]
  10. Photodynamic action of merocyanine 540 on artificial and natural cell membranes: involvement of singlet molecular oxygen. Kalyanaraman, B., Feix, J.B., Sieber, F., Thomas, J.P., Girotti, A.W. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  11. Monitoring of cerebral oxygenation in patients with severe head injuries: brain tissue PO2 versus jugular vein oxygen saturation. Kiening, K.L., Unterberg, A.W., Bardt, T.F., Schneider, G.H., Lanksch, W.R. J. Neurosurg. (1996) [Pubmed]
  12. Pulse oximeter changes with sentinel lymph node biopsy in breast cancer. El-Tamer, M., Komenaka, I.K., Curry, S., Troxel, A.B., Ditkoff, B.A., Schnabel, F.R. Archives of surgery (Chicago, Ill. : 1960) (2003) [Pubmed]
  13. Benzocaine-induced methemoglobinemia in an adult: accuracy of pulse oximetry with methemoglobinemia. Anderson, S.T., Hajduczek, J., Barker, S.J. Anesth. Analg. (1988) [Pubmed]
  14. Effect of coenzyme Q10 in patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): evaluation by noninvasive tissue oximetry. Abe, K., Matsuo, Y., Kadekawa, J., Inoue, S., Yanagihara, T. J. Neurol. Sci. (1999) [Pubmed]
  15. False indication of arterial oxygen desaturation and methemoglobinemia following injection of methylene blue in urological surgery. Kirlangitis, J.J., Middaugh, R.E., Zablocki, A., Rodriquez, F. Military medicine. (1990) [Pubmed]
  16. Cooperation of antioxidants in protection against photosensitized oxidation. Wrona, M., Korytowski, W., Rózanowska, M., Sarna, T., Truscott, T.G. Free Radic. Biol. Med. (2003) [Pubmed]
  17. The method of time-resolved spin-probe oximetry: its application to oxygen consumption by cytochrome c oxidase. Jiang, J.J., Bank, J.F., Zhao, W.W., Scholes, C.P. Biochemistry (1992) [Pubmed]
  18. Ferroxidase kinetics of human liver apoferritin, recombinant H-chain apoferritin, and site-directed mutants. Sun, S., Arosio, P., Levi, S., Chasteen, N.D. Biochemistry (1993) [Pubmed]
  19. Prototype volume-controlled resuscitator for neonates and infants. Kissoon, N., Frewen, T., Tiffin, N. Crit. Care Med. (1990) [Pubmed]
  20. Respiratory effects of clonidine alone and combined with morphine, in humans. Bailey, P.L., Sperry, R.J., Johnson, G.K., Eldredge, S.J., East, K.A., East, T.D., Pace, N.L., Stanley, T.H. Anesthesiology (1991) [Pubmed]
  21. A comparison of three pulmonary artery oximetry catheters in intensive care unit patients. Scuderi, P.E., Bowton, D.L., Meredith, J.W., Harris, L.C., Evans, J.B., Anderson, R.L. Chest (1992) [Pubmed]
  22. Detection of cerebral hypoperfusion during cardiopulmonary bypass. Continuous measurement of cerebral venous oxyhaemoglobin saturation during myocardial revascularisation. Andrews, P.J., Colquhoun, A.D. Anaesthesia. (1994) [Pubmed]
  23. Effects of optic atrophy on retinal blood flow and oxygen saturation in humans. Sebag, J., Delori, F.C., Feke, G.T., Weiter, J.J. Arch. Ophthalmol. (1989) [Pubmed]
  24. Effects of conjugated linoleic acid on oxygen diffusion-concentration product and depletion in membranes by using electron spin resonance spin-label oximetry. Yin, J.J., Mossoba, M.M., Kramer, J.K., Yurawecz, M.P., Eulitz, K., Morehouse, K.M., Ku, Y. Lipids (1999) [Pubmed]
  25. Pulmonary function and sputum production in patients with cystic fibrosis: a pilot study comparing the PercussiveTech HF device and standard chest physiotherapy. Marks, J.H., Hare, K.L., Saunders, R.A., Homnick, D.N. Chest (2004) [Pubmed]
  26. Continuous positive airway pressure during fiberoptic bronchoscopy in hypoxemic patients. A randomized double-blind study using a new device. Maitre, B., Jaber, S., Maggiore, S.M., Bergot, E., Richard, J.C., Bakthiari, H., Housset, B., Boussignac, G., Brochard, L. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  27. Intravenous morphine in postoperative infants: intermittent bolus dosing versus targeted continuous infusions. Lynn, A.M., Nespeca, M.K., Bratton, S.L., Shen, D.D. Pain (2000) [Pubmed]
  28. Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients. Honda, Y., Doi, Y., Ninomiya, R., Ninomiya, C. Sleep. (1986) [Pubmed]
  29. Electron paramagnetic resonance kinetic studies of the S states in spinach thylakoids. Razeghifard, M.R., Klughammer, C., Pace, R.J. Biochemistry (1997) [Pubmed]
  30. Oxidation of monohydric phenol substrates by tyrosinase. An oximetric study. Naish-Byfield, S., Riley, P.A. Biochem. J. (1992) [Pubmed]
  31. Experience of anesthesia for transthoracic endoscopic sympathectomy in palmar hyperhidrosis--110 cases. Chen, Y.P., Ting, M.C., Hwang, Y.S., Chow, T.C., Lin, J.C. Acta Anaesthesiol. Sin. (1994) [Pubmed]
  32. Capillary blood gases in acute exacerbations of COPD. Murphy, R., Thethy, S., Raby, S., Beckley, J., Terrace, J., Fiddler, C., Craig, M., Robertson, C. Respiratory medicine. (2006) [Pubmed]
  33. Accuracy of Doppler echocardiography in quantification of left to right shunts in adult patients with atrial septal defect. Dittmann, H., Jacksch, R., Voelker, W., Karsch, K.R., Seipel, L. J. Am. Coll. Cardiol. (1988) [Pubmed]
  34. Validation of British Thoracic Society guidelines for the diagnosis of the sleep apnoea/hypopnoea syndrome: can polysomnography be avoided? Ryan, P.J., Hilton, M.F., Boldy, D.A., Evans, A., Bradbury, S., Sapiano, S., Prowse, K., Cayton, R.M. Thorax (1995) [Pubmed]
  35. The distribution of costs of care in mechanically ventilated patients with chronic obstructive pulmonary disease. Ely, E.W., Baker, A.M., Evans, G.W., Haponik, E.F. Crit. Care Med. (2000) [Pubmed]
  36. Efficacy of pulse oximetry and capnometry in postoperative ventilatory weaning. Niehoff, J., DelGuercio, C., LaMorte, W., Hughes-Grasberger, S.L., Heard, S., Dennis, R., Yeston, N. Crit. Care Med. (1988) [Pubmed]
  37. Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution. Przybelski, R.J., Daily, E.K., Kisicki, J.C., Mattia-Goldberg, C., Bounds, M.J., Colburn, W.A. Crit. Care Med. (1996) [Pubmed]
  38. Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor. Hunjan, S., Zhao, D., Constantinescu, A., Hahn, E.W., Antich, P.P., Mason, R.P. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
  39. Safety and efficacy of Omniscan (gadodiamide injection) at 0.1 mmol/kg for MRI in infants younger than 6 months of age: phase III open multicenter study. Martí-Bonmatí, L., Vega, T., Benito, C., Muñoz, A., Niewel, M., Menor, F., Meurer, K., Encina, J.L. Investigative radiology. (2000) [Pubmed]
  40. Predictors of oxygen desaturation during submaximal exercise in 8,000 patients. Hadeli, K.O., Siegel, E.M., Sherrill, D.L., Beck, K.C., Enright, P.L. Chest (2001) [Pubmed]
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