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Chemical Compound Review

Corundum     oxo-oxoalumanyloxy-alumane

Synonyms: Sapphire, Korund, Emery, alpha-Corundum, ALUMINA C, ...
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Disease relevance of ALUMINUM OXIDE


Psychiatry related information on ALUMINUM OXIDE

  • EEG operant conditioning in an alumina-gel monkey model (N = 14) to decrease EMG, to increase 9 Hz or decrease 9 Hz, and to increase 23 Hz (18 Hz and 26 Hz in 2 pilot monkeys), respectively, was not consistently beneficial in reducing seizures [5].
  • Reaction of 7-amino-3-[5'-methyl-1',3',4'-thiadiazol-2'-ylthiomethyl]cephalo-sporanic acid with heterocyclic amines using basic alumina under microwave irradiation (MWI) afforded new cephalosporin analogs in shorter reaction time with improved yield as compared to conventional heating [6].
  • In 12 rhesus monkeys, made epileptic by injection of alumina cream into the temporal lobe structures, the changes of spike frequency were studied in wakefulness and natural sleep on 78 occasions [7].

High impact information on ALUMINUM OXIDE

  • There are reports of nanotubes made from silica, alumina, silicon and metals that do not have a layered crystal structure; they are synthesized by using carbon nanotubes and porous membranes as templates, or by thin-film rolling [8].
  • The in vitro slice technique was used to study neuronal activity in human cortical tissue removed during neurosurgical procedures for intractable epilepsy and in monkey neocortex rendered epileptogenic by injection of alumina gel [9].
  • The enzyme seems to have been solubilized from the mitochondrial membrane fraction by treatment with sodium deoxycholate followed by dialysis and subsequent adsorption by and elution from alumina C gamma [10].
  • Synthesis, spectroscopy, and catalytic properties of cationic organozirconium adsorbates on "super acidic" sulfated alumina. "Single-site" heterogeneous catalysts with virtually 100 active sites [11].
  • The TEM studies on the sonochemically prepared catalysts indicate the formation of layered hexagonal MoS(2) (lattice fringes approximately 6.2 A) on the alumina support [12].

Chemical compound and disease context of ALUMINUM OXIDE

  • Qualitative and quantitative aspects of chronic carbamazepine (Tegretol) medication on focal seizures and associated interictal EEG abnormalities in Rhesus monkeys with alumina-induced foci in either the sensorimotor cortex or the hipocampus was investigated [13].
  • Effect of carbachol "push--pull" perfusion in the reticular formation on alumina cream-induced focal motor seizures in cats [14].
  • Since virtually all monkeys treated with alumina gel develop seizures, the results of this study add further support to the hypothesis that GABA neuronal loss plays a causal role in focal epilepsy [15].
  • The aim of this work is to study catalytic ethanol dehydration using different prepared catalysts, which include Fe(2)O(3), Mn(2)O(3), and calcined physical mixtures of both ferric and manganese oxides with alumina and/or silica gel [16].
  • Four yttrium-stabilized alumina ceramic-on-polyethylene articulations obtained from patients who were undergoing revision surgery for sepsis (3) or recurrent dislocation (I) between 34 and 73 months were evaluated to assess their in vivo wear performance [17].

Biological context of ALUMINUM OXIDE

  • In the case of hydrolytic interaction of Ach or beta-MeAch, the products of the hydrolysis, acetate ion and choline--the latter also adsorbed in ionic form--were found on the alumina surface [18].
  • Detection limits in the analysis of Cy5-labeled IgG are 0.02 ng/mL because of the high surface area of the alumina membrane, and the minimal diameter of the substrate pores results in binding limited by kinetics, not mass transport [19].
  • The association of alumina treatment of perfluorocarbon liquids with a reduction in cell growth was indicative of a relationship between the presence of residual hydrogen-containing impurities and the capacity for cellular attachment and growth [20].
  • Serum samples with added 14C-labeled bile acid were submitted to deproteinization, alkaline hydrolysis, methylation, and were then chromatographed on alumina before acetylation with 2 microliters of [3H]acetic anhydride [21].
  • The dissolution process of Al(2)O(3) at the backside of the pores was monitored by electrical impedance spectroscopy ensuring the desired sieve-like structure of the porous alumina [22].

Anatomical context of ALUMINUM OXIDE

  • Ribosomes prepared from bacteria ground with washed sea sand were more immunogenic than those obtained by rupture with alumina or with a Braun homogenizer [23].
  • Intramedullary or subarachnoid injections of alumina cream were made in the lumbar region of 38 adult cats [3].
  • Purple membranes were adsorbed on freestanding lipid bilayers, termed nano-black lipid membranes (nano-BLMs), suspending the pores of porous alumina substrates with average pore diameters of 280 nm [24].
  • A method is described for accurate and reproducible measurement of squalene in plasma, feces, urine, bile, and tissue that depends on isolation by alumina column chromatography after mild saponification and on measurement by gas-liquid chromatography [25].
  • Chronic alumina temporal lobe seizures in monkeys [26].

Associations of ALUMINUM OXIDE with other chemical compounds


Gene context of ALUMINUM OXIDE

  • Treatment of J744 cells with alumina particles increased TNF-alpha secretion, but the induction was lower when cells were cocultured with osteoblasts [33].
  • Coculturing osteoblasts with J744 cells induced them to release IL-6 and GM-CSF, and treatment with alumina further increased the secretion of both mediators by osteoblasts [33].
  • Development of new dye-metal agarose-coated alumina matrix and elution strategy for purification of alcohol dehydrogenase [34].
  • The hypothesis incorporates findings from both penicillin and alumina models of epilepsy and provides experimentally testable concepts for further investigation [35].
  • The off state was obtained by making the membranes hydrophobic by chemisorbing either a C18 silane (alumina membrane) or a C18 thiol (Au nanotube membrane) [36].

Analytical, diagnostic and therapeutic context of ALUMINUM OXIDE


  1. Pb(II) distributions at biofilm-metal oxide interfaces. Templeton, A.S., Trainor, T.P., Traina, S.J., Spormann, A.M., Brown, G.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. Alumina cream-induced focal motor epilepsy in cats. IV. Thickness and cellularity of layers in the perilesional motor cortex. Feria-Velasco, A., Olivares, N., Rivas, F., Velasco, M., Velasco, F. Arch. Neurol. (1980) [Pubmed]
  3. Intraspinal alumina injection: the relationship between epileptiform focus, root scarring and chronic pain. Loeser, J.D., Peirce, K.R. Pain (1978) [Pubmed]
  4. Ultrathin alumina sol-gel-derived films: allowing direct detection of the liver fibrosis markers by capacitance measurement. Jiang, D., Tang, J., Liu, B., Yang, P., Kong, J. Anal. Chem. (2003) [Pubmed]
  5. EEG operant conditioning in a monkey model: I. Seizure data. Lockard, J.S., Wyler, A.R., Finch, C.A., Hurlburt, K.E. Epilepsia (1977) [Pubmed]
  6. Microwave induced synthesis and antibacterial activity of cephalosporin derivatives using solid support. Kidwai, M., Sapra, P., Bhushan, K.R., Misra, P., Saxena, R.K., Gupta, R., Singh, M. Bioorg. Chem. (2001) [Pubmed]
  7. The influence of natural sleep on focal spiking in experimental temporal lobe epilepsy in the monkey. Mayanagi, Y. Electroencephalography and clinical neurophysiology. (1977) [Pubmed]
  8. Single-crystal gallium nitride nanotubes. Goldberger, J., He, R., Zhang, Y., Lee, S., Yan, H., Choi, H.J., Yang, P. Nature (2003) [Pubmed]
  9. Studies of human and monkey "epileptic" neocortex in the in vitro slice preparation. Schwartzkroin, P.A., Turner, D.A., Knowles, W.D., Wyler, A.R. Ann. Neurol. (1983) [Pubmed]
  10. Demonstration and possible function of NADH:NAD+ transhydrogenase from ascaris muscle mitochondria. Köhler, P., Saz, H.J. J. Biol. Chem. (1976) [Pubmed]
  11. Synthesis, spectroscopy, and catalytic properties of cationic organozirconium adsorbates on "super acidic" sulfated alumina. "Single-site" heterogeneous catalysts with virtually 100 active sites. Nicholas, C.P., Ahn, H., Marks, T.J. J. Am. Chem. Soc. (2003) [Pubmed]
  12. Sonochemical preparation of supported hydrodesulfurization catalysts. Dhas, N.A., Ekhtiarzadeh, A., Suslick, K.S. J. Am. Chem. Soc. (2001) [Pubmed]
  13. Effect of carbamazepine (Tegretol) on seizure and EEG patterns in monkeys with alumina-induced focal motor and hippocampal foci. David, J., Grewal, R.S. Epilepsia (1976) [Pubmed]
  14. Effect of carbachol "push--pull" perfusion in the reticular formation on alumina cream-induced focal motor seizures in cats. Velasco, M., Velasco, F., Romo, R., Martínez, A. Exp. Neurol. (1981) [Pubmed]
  15. A selective decrease in the number of GABAergic somata occurs in pre-seizing monkeys with alumina gel granuloma. Ribak, C.E., Joubran, C., Kesslak, J.P., Bakay, R.A. Epilepsy Res. (1989) [Pubmed]
  16. Catalytic dehydration of ethanol using transition metal oxide catalysts. Zaki, T. Journal of colloid and interface science. (2005) [Pubmed]
  17. Wear of retrieved cemented polyethylene acetabula with alumina femoral heads. Bragdon, C.R., Jasty, M., Kawate, K., McGrory, B.J., Elder, J.R., Lowenstein, J., Harris, W.H. The Journal of arthroplasty. (1997) [Pubmed]
  18. Inelastic electron tunneling spectroscopic study of interaction of acetylcholine and beta-methyl acetylcholine with alumina surface. Aslanian, D., de Cheveigné, S. Mol. Pharmacol. (1982) [Pubmed]
  19. Use of porous membranes modified with polyelectrolyte multilayers as substrates for protein arrays with low nonspecific adsorption. Dai, J., Baker, G.L., Bruening, M.L. Anal. Chem. (2006) [Pubmed]
  20. Fibroblast behavior at aqueous interfaces with perfluorocarbon, silicone, and fluorosilicone liquids. Sparrow, J.R., Ortiz, R., MacLeish, P.R., Chang, S. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  21. Isotope derivative assay of human serum bile acids. Pageaux, J.F., Duperray, B., Dubois, M., Pacheco, H. J. Lipid Res. (1981) [Pubmed]
  22. Impedance analysis and single-channel recordings on nano-black lipid membranes based on porous alumina. Römer, W., Steinem, C. Biophys. J. (2004) [Pubmed]
  23. Evaluation of a ribosomal vaccine against pertussis. Field, L.H., Parker, C.D., Manclark, C.R., Berry, L.J. Infect. Immun. (1979) [Pubmed]
  24. Photocurrents generated by bacteriorhodopsin adsorbed on nano-black lipid membranes. Horn, C., Steinem, C. Biophys. J. (2005) [Pubmed]
  25. Measurement of squalene in human tissues and plasma: validation and application. Liu, G.C., Ahrens, E.H., Schreibman, P.H., Crouse, J.R. J. Lipid Res. (1976) [Pubmed]
  26. Chronic alumina temporal lobe seizures in monkeys. Soper, H.V., Strain, G.M., Babb, T.L., Lieb, J.P., Crandall, P.H. Exp. Neurol. (1978) [Pubmed]
  27. Capillary filling of anodized alumina nanopore arrays. Alvine, K.J., Shpyrko, O.G., Pershan, P.S., Shin, K., Russell, T.P. Phys. Rev. Lett. (2006) [Pubmed]
  28. Metallorganic routes to nanoscale iron and titanium oxide particles encapsulated in mesoporous alumina: formation, physical properties, and chemical reactivity. Schneider, J.J., Czap, N., Hagen, J., Engstler, J., Ensling, J., Gütlich, P., Reinoehl, U., Bertagnolli, H., Luis, F., de Jongh, L.J., Wark, M., Grubert, G., Hornyak, G.L., Zanoni, R. Chemistry (Weinheim an der Bergstrasse, Germany) (2000) [Pubmed]
  29. Demonstration of conjugated dopamine in monkey CSF by gas chromatography-mass spectrometry. Elchisak, M.A., Powers, K.H., Ebert, M.H. J. Neurochem. (1982) [Pubmed]
  30. Solid-phase extraction of amphiphiles based on mixed hemimicelle/admicelle formation: application to the concentration of benzalkonium surfactants in sewage and river water. Merino, F., Rubio, S., Pérez-Bendito, D. Anal. Chem. (2003) [Pubmed]
  31. Characterization of aerogel prepared high-surface-area alumina: in situ FTIR study of dehydroxylation and pyridine adsorption. Khaleel, A.A., Klabunde, K.J. Chemistry (Weinheim an der Bergstrasse, Germany) (2002) [Pubmed]
  32. Organic nanowire-templated fabrication of alumina nanotubes by atomic layer deposition. Wang, C.C., Kei, C.C., Yu, Y.W., Perng, T.P. Nano Lett. (2007) [Pubmed]
  33. Alumina particles influence the interactions of cocultured osteoblasts and macrophages. Rodrigo, A., Vallés, G., Saldaña, L., Rodríguez, M., Martínez, M.E., Munuera, L., Vilaboa, N. J. Orthop. Res. (2006) [Pubmed]
  34. Development of new dye-metal agarose-coated alumina matrix and elution strategy for purification of alcohol dehydrogenase. Hidayat, C., Nakajima, M., Takagi, M., Yoshida, T. J. Biosci. Bioeng. (2003) [Pubmed]
  35. Mechanisms underlying epileptiform burst discharge. Schwartzkroin, P.A., Wyler, A.R. Ann. Neurol. (1980) [Pubmed]
  36. Ion channel mimetic micropore and nanotube membrane sensors. Steinle, E.D., Mitchell, D.T., Wirtz, M., Lee, S.B., Young, V.Y., Martin, C.R. Anal. Chem. (2002) [Pubmed]
  37. Imaging the atomic arrangements on the high-temperature reconstructed alpha-Al2O3(0001) surface. Barth, C., Reichling, M. Nature (2001) [Pubmed]
  38. Influence of the metal substrate on the adsorption properties of thin oxide layers: Au atoms on a thin alumina film on NiAl(110). Kulawik, M., Nilius, N., Freund, H.J. Phys. Rev. Lett. (2006) [Pubmed]
  39. Liquid alumina: detailed atomic coordination determined from neutron diffraction data using empirical potential structure refinement. Landron, C., Hennet, L., Jenkins, T.E., Greaves, G.N., Coutures, J.P., Soper, A.K. Phys. Rev. Lett. (2001) [Pubmed]
  40. The fate of 17 beta-estradiol in the plasma of premenopausal and postmenopausal patients with cancer. Vaughn, C.B., Kolakowski, D., Zylka, U., Brooks, S.C. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  41. Development of a detector for liquid chromatography based on aerosol chemiluminescence on porous alumina. Lv, Y., Zhang, S., Liu, G., Huang, M., Zhang, X. Anal. Chem. (2005) [Pubmed]
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