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Gene Review

RBM6  -  RNA binding motif protein 6

Homo sapiens

Synonyms: 3G2, DEF-3, DEF3, HLC-11, Lung cancer antigen NY-LU-12, ...
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Disease relevance of RBM6


High impact information on RBM6

  • Screening of normal and cancer patient sera showed anti-NY-LU-12 seroreactivity in 2 of 21 allogeneic lung cancer patients but not in 24 patients with other tumors or in 16 sera from healthy donors [3].
  • Cloning of full-length NY-LU-12 showed that this cDNA was derived from the same gene as g16, a partially sequenced gene that mapped to the lung cancer tumor suppressor gene locus on chromosome 3p21 [3].
  • Analysis of the putative NY-LU-12 protein sequence predicted that it is a nuclear zinc finger protein with two RNA-binding domains, and Southern analysis showed that this gene is partially deleted in the lung cancer line NCI-H740 but not in nine other lung cancer lines [3].
  • As a result of alternate splicing and subsequent frameshift, the reported g16 protein is 603 amino acids shorter than the NY-LU-12 product (1123 residues) at its COOH terminus and would therefore lack the epitopes recognized by the autologous serum [3].
  • DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC [2].

Biological context of RBM6

  • In searching for a tumor suppressor gene in the 3p21.3 region, we isolated two genes, RBM5 and RBM6 [4].
  • The high sequence homology at the amino acid level between RBM5, RBM6, and particularly, RBM10 suggests that they, too, may play an important role in regulating apoptosis [5].
  • They contain two zinc finger motifs, a bipartite nuclear signal and two RNA binding motifs, suggesting that the proteins for which RBM5 and RBM6 are coding have a DNA/RNA binding function and are located in the nucleus [1].
  • In the search for a tumour suppressor gene in the 3p21.3 region we isolated two genes, RBM5 and RBM6 [1].
  • DEF-3(g16/NY-LU-12) is ubiquitously expressed during mouse embryogenesis and in adult organs while human hematopoietic tissues showed differential expression [2].

Analytical, diagnostic and therapeutic context of RBM6

  • Competitive enzyme immunoassay experiments with O-polysaccharide preparations derived from IID 1001, NCTC 8505 (serotype A) and IID 1009 (serotype H) and their derivatives demonstrated that the N-acetyl-L-galactosaminuronic acid residue in O-polysaccharide was essentially involved in the epitope for TS-3G2 [6].


  1. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. Timmer, T., Terpstra, P., van den Berg, A., Veldhuis, P.M., Ter Elst, A., Voutsinas, G., Hulsbeek, M.M., Draaijers, T.G., Looman, M.W., Kok, K., Naylor, S.L., Buys, C.H. Eur. J. Hum. Genet. (1999) [Pubmed]
  2. DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC. Drabkin, H.A., West, J.D., Hotfilder, M., Heng, Y.M., Erickson, P., Calvo, R., Dalmau, J., Gemmill, R.M., Sablitzky, F. Oncogene (1999) [Pubmed]
  3. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. Güre, A.O., Altorki, N.K., Stockert, E., Scanlan, M.J., Old, L.J., Chen, Y.T. Cancer Res. (1998) [Pubmed]
  4. An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers. Timmer, T., Terpstra, P., van den Berg, A., Veldhuis, P.M., Ter Elst, A., van der Veen, A.Y., Kok, K., Naylor, S.L., Buys, C.H. Genomics (1999) [Pubmed]
  5. RNA binding motif (RBM) proteins: a novel family of apoptosis modulators? Sutherland, L.C., Rintala-Maki, N.D., White, R.D., Morin, C.D. J. Cell. Biochem. (2005) [Pubmed]
  6. N-acetyl-L-galactosaminuronic acid as an epitope common to the O-polysaccharides of Pseudomonas aeruginosa serotype A and H (Homma) recognized by a protective human monoclonal antibody. Yokota, S., Ochi, H., Uezumi, I., Ohtsuka, H., Irie, K., Noguchi, H. Eur. J. Biochem. (1990) [Pubmed]
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