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Gene Review

RBM5  -  RNA binding motif protein 5

Homo sapiens

Synonyms: G15, H37, LUCA15, Protein G15, RMB5, ...
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Disease relevance of RBM5


High impact information on RBM5


Chemical compound and disease context of RBM5


Biological context of RBM5


Anatomical context of RBM5


Associations of RBM5 with chemical compounds

  • Growing evidence, however, indicates that Gqalpha, G11alpha, G14alpha and G15/16alpha are functionally diverse and that many of their cellular actions are independent of inositol lipid signalling [17].
  • The crystal structure of the N12G/A18G mutant protein shows changes in main chain position as well as repositioning of H37, which disrupts contacts with the adenine ring of NAD+, changes which are predicted to reduce the binding affinity for this dinucleotide [18].
  • A fraction is isolated from human uremic plasma and normal urine using a three step chromatographic separation :gel permeation on Sephadex G15, then chromatography on hydroxyapatite and finally desalting operation on Sephadex G15 [19].
  • Elution with 1 M acetic acid through Sephadex G15 produces three peaks, only one of which contains the biological activity [20].
  • Comparisons were made with Sepharose 4B-, Sephadex G15-, and G25-based Cibacron blue F3GA systems [21].

Regulatory relationships of RBM5

  • Interestingly, loss of LUCA-15 was positively correlated with decreased susceptibility to the death-inducing ligand TNF-alpha [22].

Other interactions of RBM5


Analytical, diagnostic and therapeutic context of RBM5


  1. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. Timmer, T., Terpstra, P., van den Berg, A., Veldhuis, P.M., Ter Elst, A., Voutsinas, G., Hulsbeek, M.M., Draaijers, T.G., Looman, M.W., Kok, K., Naylor, S.L., Buys, C.H. Eur. J. Hum. Genet. (1999) [Pubmed]
  2. Expression of RBM5-related factors in primary breast tissue. Rintala-Maki, N.D., Goard, C.A., Langdon, C.E., Wall, V.E., Traulsen, K.E., Morin, C.D., Bonin, M., Sutherland, L.C. J. Cell. Biochem. (2007) [Pubmed]
  3. A candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3. Oh, J.J., West, A.R., Fishbein, M.C., Slamon, D.J. Cancer Res. (2002) [Pubmed]
  4. DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC. Drabkin, H.A., West, J.D., Hotfilder, M., Heng, Y.M., Erickson, P., Calvo, R., Dalmau, J., Gemmill, R.M., Sablitzky, F. Oncogene (1999) [Pubmed]
  5. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. Scanlan, M.J., Gordan, J.D., Williamson, B., Stockert, E., Bander, N.H., Jongeneel, V., Gure, A.O., Jäger, D., Jäger, E., Knuth, A., Chen, Y.T., Old, L.J. Int. J. Cancer (1999) [Pubmed]
  6. The Dewar photoproduct of thymidylyl(3'-->5')- thymidine (Dewar product) exhibits mutagenic behavior in accordance with the "A rule". Lee, J.H., Bae, S.H., Choi, B.S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  7. 3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis. Oh, J.J., Razfar, A., Delgado, I., Reed, R.A., Malkina, A., Boctor, B., Slamon, D.J. Cancer Res. (2006) [Pubmed]
  8. Permutation of a pair of tertiary nucleotides in a transfer RNA. Hou, Y.M., Sterner, T., Jansen, M. Biochemistry (1995) [Pubmed]
  9. Comparison of ribosomes and ribosomal proteins of sensitive and resistant mycobacteria. Medow, I., Rüsch-Gerdes, S., Schröder, K.H. Zentralblatt für Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology. (1987) [Pubmed]
  10. Polystyrene, poly-L-lysine and nylon as adsorptive surfaces for the binding of whole cells of Mycobacterium tuberculosis H37 RV to ELISA plates. Verschoor, J.A., Meiring, M.J., van Wyngaardt, S., Weyer, K. Journal of immunoassay. (1990) [Pubmed]
  11. An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers. Timmer, T., Terpstra, P., van den Berg, A., Veldhuis, P.M., Ter Elst, A., van der Veen, A.Y., Kok, K., Naylor, S.L., Buys, C.H. Genomics (1999) [Pubmed]
  12. RNA binding motif (RBM) proteins: a novel family of apoptosis modulators? Sutherland, L.C., Rintala-Maki, N.D., White, R.D., Morin, C.D. J. Cell. Biochem. (2005) [Pubmed]
  13. Simultaneous acceleration of the cell cycle and suppression of apoptosis by splice variant delta-6 of the candidate tumour suppressor LUCA-15/RBM5. Mourtada-Maarabouni, M., Sutherland, L.C., Meredith, J.M., Williams, G.T. Genes Cells (2003) [Pubmed]
  14. LUCA-15 suppresses CD95-mediated apoptosis in Jurkat T cells. Sutherland, L.C., Lerman, M., Williams, G.T., Miller, B.A. Oncogene (2001) [Pubmed]
  15. Increased degranulation of eosinophil and neutrophil granulocytes in cystic fibrosis. Koller, D.Y., Urbanek, R., Götz, M. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  16. Protective and nonprotective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles. Maitta, R.W., Datta, K., Chang, Q., Luo, R.X., Witover, B., Subramaniam, K., Pirofski, L.A. Infect. Immun. (2004) [Pubmed]
  17. Cell signalling diversity of the Gqalpha family of heterotrimeric G proteins. Hubbard, K.B., Hepler, J.R. Cell. Signal. (2006) [Pubmed]
  18. Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis. Lamb, H.K., Ren, J., Park, A., Johnson, C., Leslie, K., Cocklin, S., Thompson, P., Mee, C., Cooper, A., Stammers, D.K., Hawkins, A.R. Protein Sci. (2004) [Pubmed]
  19. Partial purification of a calcium ionophore from human uremic plasma and normal urine. Fournier, N., Crevat, A., Ducet, G., Murisasco, A. Biochem. Biophys. Res. Commun. (1983) [Pubmed]
  20. The presynaptic effect of fractions isolated from the sponge Tedania ignis. Sevcik, C., Barboza, C.A. Toxicon (1983) [Pubmed]
  21. Investigation into the use of graft copolymer-based cibacron blue F3GA columns for the purification of proteins. Beddows, C.G., Morris, R.A., Guthrie, J.T. Biotechnol. Appl. Biochem. (1986) [Pubmed]
  22. Genetic instability of RBM5/LUCA-15/H37 in MCF-7 breast carcinoma sublines may affect susceptibility to apoptosis. Rintala-Maki, N.D., Abrasonis, V., Burd, M., Sutherland, L.C. Cell Biochem. Funct. (2004) [Pubmed]
  23. LUCA-15/RBM5, a putative tumour suppressor, enhances multiple receptor-initiated death signals. Rintala-Maki, N.D., Sutherland, L.C. Apoptosis (2004) [Pubmed]
  24. Candidate tumor suppressor LUCA-15/RBM5/H37 modulates expression of apoptosis and cell cycle genes. Mourtada-Maarabouni, M., Keen, J., Clark, J., Cooper, C.S., Williams, G.T. Exp. Cell Res. (2006) [Pubmed]
  25. Fluorescent substances in uremic and normal serum. Shaykh, M., Bazilinski, N., McCaul, D.S., Ahmed, S., Dubin, A., Musiala, T., Dunea, G. Clin. Chem. (1985) [Pubmed]
  26. Mismatch recovery of regional cerebral blood flow and brain temperature during reperfusion after prolonged brain ischemia in gerbils. Tajima, G., Shiozaki, T., Seiyama, A., Mohri, T., Kajino, K., Nakae, H., Tasaki, O., Ogura, H., Kuwagata, Y., Tanaka, H., Shimazu, T., Sugimoto, H. The Journal of trauma (2007) [Pubmed]
  27. The serodiagnosis of tuberculosis in children: an evaluation of an ELISA test using IgG antibodies to M. tuberculosis, strain H37 RV. Hussey, G., Kibel, M., Dempster, W. Annals of tropical paediatrics. (1991) [Pubmed]
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