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Gene Review

INADL  -  InaD-like (Drosophila)

Homo sapiens

Synonyms: Cipp, InaD-like, InaD-like protein, Inadl protein, PATJ, ...
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High impact information on INADL


Biological context of INADL

  • We have produced downregulated PATJ stable lines of Caco2 to clarify its role in epithelial morphogenesis [5].
  • Furthermore, our results show that microtubule-organizing centre orientation is disrupted in PATJ RNA interference (RNAi) MDCKII (Madin-Darby canine kidney II) cells during migration [6].

Anatomical context of INADL

  • Here, we observed that the Pals1/PATJ interaction was not crucial for the ultimate targeting of PATJ itself to tight junctions [7].
  • Furthermore, exogenously expressed PALS1, but not other Lin-7 binding partners, also rescued the effects of Lin-7 knock down, including the restoration of PATJ protein in rescued cell lines [8].
  • The migration defect in PATJ RNAi cells seems to be due to the disorganization of the microtubule network induced by mislocalization of polarity proteins [6].

Physical interactions of INADL

  • Thus, PATJ stabilizes the Crb3 complex and regulates the spatial concentration of several components at the border between the apical and lateral domains [5].

Other interactions of INADL

  • Finally, reciprocal co-immunoprecipitation experiments revealed that full-length ZO-3 can associate with PATJ [7].
  • We have identified the tight junction-associated multi-PDZ protein PATJ (PALS1-associated TJ protein) as a novel binding partner and degradation target of high-risk types 16 and 18 E6 [9].

Analytical, diagnostic and therapeutic context of INADL


  1. PATJ regulates tight junction formation and polarity in mammalian epithelial cells. Shin, K., Straight, S., Margolis, B. J. Cell Biol. (2005) [Pubmed]
  2. Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes. Li, Y., Karnak, D., Demeler, B., Margolis, B., Lavie, A. EMBO J. (2004) [Pubmed]
  3. The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost. Roh, M.H., Makarova, O., Liu, C.J., Shin, K., Lee, S., Laurinec, S., Goyal, M., Wiggins, R., Margolis, B. J. Cell Biol. (2002) [Pubmed]
  4. Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex. Massey-Harroche, D., Delgrossi, M.H., Lane-Guermonprez, L., Arsanto, J.P., Borg, J.P., Billaud, M., Le Bivic, A. Hum. Mol. Genet. (2007) [Pubmed]
  5. PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells. Michel, D., Arsanto, J.P., Massey-Harroche, D., Béclin, C., Wijnholds, J., Le Bivic, A. J. Cell. Sci. (2005) [Pubmed]
  6. PATJ regulates directional migration of mammalian epithelial cells. Shin, K., Wang, Q., Margolis, B. EMBO Rep. (2007) [Pubmed]
  7. The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions. Roh, M.H., Liu, C.J., Laurinec, S., Margolis, B. J. Biol. Chem. (2002) [Pubmed]
  8. Mammalian lin-7 stabilizes polarity protein complexes. Straight, S.W., Pieczynski, J.N., Whiteman, E.L., Liu, C.J., Margolis, B. J. Biol. Chem. (2006) [Pubmed]
  9. PATJ, a Tight Junction-Associated PDZ Protein, Is a Novel Degradation Target of High-Risk Human Papillomavirus E6 and the Alternatively Spliced Isoform 18 E6. Storrs, C.H., Silverstein, S.J. J. Virol. (2007) [Pubmed]
  10. Evidence that TRPC3 is a molecular component of the 1alpha,25(OH)2D3-activated capacitative calcium entry (CCE) in muscle and osteoblast cells. Santillán, G., Baldi, C., Katz, S., Vazquez, G., Boland, R. J. Steroid Biochem. Mol. Biol. (2004) [Pubmed]
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