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Gene Review

IFI30  -  interferon, gamma-inducible protein 30

Homo sapiens

Synonyms: GILT, Gamma-interferon-inducible lysosomal thiol reductase, Gamma-interferon-inducible protein IP-30, IFI-30, IP-30, ...
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Disease relevance of IFI30

  • Neither IP-30 nor HIV PR 76-84 activated CTL against themselves following in vitro stimulation of PBMC from non-HIV-infected HLA-A2 individuals [1].
  • Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation [2]?

High impact information on IFI30

  • PGCP was co-purified from human placenta with lysosomal carboxypeptidase, cathepsin A, lysosomal endopeptidase, cathepsin D, and a gamma-interferon-inducible protein, IP-30, using an affinity chromatography on a Phe-Leu-agarose column [3].
  • These data are consistent with IP-30 being a novel IFN gamma-inducible protein which may be lysosomal in location [4].
  • Neither high levels of exogenous IFN-gamma nor incubation of PBMC with other HIV peptides triggering substantial IFN-gamma release activated IP-30-specific CTL [1].
  • Stimulation of peripheral blood mononuclear cells (PBMC) from HLA-A2 human immunodeficiency virus type 1 (HIV-1)-infected individuals with an HLA-A2-restricted HIV protease (PR) peptide 76-84 (LVGPTPVNI) activated cytotoxic T lymphocytes (CTL) against the IP-30 signal peptide [1].
  • Peptide titrations indicated higher-avidity T-cell interactions with HIV PR 76-84 than with the IP-30 signal peptide [1].

Biological context of IFI30

  • The gamma interferon (IFN-gamma)-inducible protein 30 (IP-30) signal peptide -11 to -3 (LLDVPTAAV) is a prominent self peptide expressed with the class I human histocompatibility leukocyte antigen A2 (HLA-A2) [1].
  • These data indicate that HIV PR 76-84 is a heteroclitic variant of the IP-30 signal peptide -11 to -3, which has implications for immune memory and autoimmunity [1].
  • Among them, thymus-expressed chemokine (TECK) and IP-30 were dramatically induced by Egr-1, but TNFalpha-related apoptosis inducing ligand (TRAIL) was significantly repressed by Egr-1, suggesting that Egr-1 is a key mediator of inflammation and apoptosis in vascular cells [5].

Associations of IFI30 with chemical compounds

  • SR 141716 was given IP 30 min before the injection of stimulant drugs [6].
  • Haloperidol (0.3 mg/kg IP), administered 40 min before lisuride, did not modify the antagonistic effect on wet shakes, unlike sulpiride (40 mg/kg IP 30 min before lisuride), but at the same time blocked the increase in escape attempts and aggressiveness induced by lisuride [7].
  • The lysosomal proteins consisted of gamma-interferon-inducible protein (IP-30), Saposin D, cathepsins B and D, beta-hexosaminidase, palmitoyl protein thioesterase, alpha-glucosidase, and LAMP-1 [8].


  1. Cross-reactive cytotoxic T lymphocytes against human immunodeficiency virus type 1 protease and gamma interferon-inducible protein 30. Mason, R.D., Bowmer, M.I., Howley, C.M., Grant, M.D. J. Virol. (2005) [Pubmed]
  2. Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation? Schuelke, M., Loeffen, J., Mariman, E., Smeitink, J., van den Heuvel, L. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  3. Purification, cDNA cloning, and expression of a new human blood plasma glutamate carboxypeptidase homologous to N-acetyl-aspartyl-alpha-glutamate carboxypeptidase/prostate-specific membrane antigen. Gingras, R., Richard, C., El-Alfy, M., Morales, C.R., Potier, M., Pshezhetsky, A.V. J. Biol. Chem. (1999) [Pubmed]
  4. Molecular and biochemical characterization of a novel gamma-interferon-inducible protein. Luster, A.D., Weinshank, R.L., Feinman, R., Ravetch, J.V. J. Biol. Chem. (1988) [Pubmed]
  5. Egr-1 target genes in human endothelial cells identified by microarray analysis. Fu, M., Zhu, X., Zhang, J., Liang, J., Lin, Y., Zhao, L., Ehrengruber, M.U., Chen, Y.E. Gene (2003) [Pubmed]
  6. Blockade of cannabinoid (CB1) receptors by 141716 selectively antagonizes drug-induced reinstatement of exploratory behaviour in gerbils. Poncelet, M., Barnouin, M.C., Brelière, J.C., Le Fur, G., Soubrié, P. Psychopharmacology (Berl.) (1999) [Pubmed]
  7. Influence of lisuride on morphine withdrawal signs in the rat: a dopamine-mimetic effect. Ferrari, F., Baggio, G. Psychopharmacology (Berl.) (1982) [Pubmed]
  8. Two-dimensional mapping and microsequencing of lysosomal proteins from human placenta. Chataway, T.K., Whittle, A.M., Lewis, M.D., Bindloss, C.A., Davey, R.C., Moritz, R.L., Simpson, R.J., Hopwood, J.J., Meikle, P.J. Placenta (1998) [Pubmed]
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