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Gene Review

CCL25  -  chemokine (C-C motif) ligand 25

Homo sapiens

Synonyms: C-C motif chemokine 25, Chemokine TECK, Ckb15, SCYA25, Small-inducible cytokine A25, ...
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Disease relevance of CCL25


High impact information on CCL25

  • We conclude that TECK represents a novel thymic dendritic cell-specific CC chemokine that is possibly involved in T cell development [6].
  • The source of TECK in the thymus was determined to be thymic dendritic cells; in contrast, bone marrow-derived dendritic cells do not express TECK [6].
  • Besides the thymus, mRNA encoding TECK was detected at substantial levels in the small intestine and at low levels in the liver [6].
  • The murine TECK recombinant protein showed chemotactic activity for activated macrophages, dendritic cells, and thymocytes [6].
  • TECK has weak homology to other CC chemokines and maps to mouse chromosome 8 [6].

Biological context of CCL25


Anatomical context of CCL25

  • Furthermore, the venular endothelial cells in small intestine were positive for CCL25 and CCL28, whereas those in colon were positive for CCL28, suggesting their direct roles in extravasation of IgA ASCs [7].
  • Collectively, CCL25 and CCL28 play essential roles in intestinal homing of IgA ASCs primarily by mediating their extravasation into intestinal lamina propria [7].
  • TECK attracts predominantly the T cell fraction of small bowel LPMC, whereas sorted CD3(+)CCR9(+) and CD3(+)CCR9(-) lymphocytes produce similar Th1 or Th2 cytokines at the single cell level [2].
  • Thymus-expressed chemokine (TECK) has been reported to chemoattract dendritic cells, thymocytes, and activated macrophages [10].
  • The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system [2].

Associations of CCL25 with chemical compounds


Regulatory relationships of CCL25


Other interactions of CCL25


Analytical, diagnostic and therapeutic context of CCL25


  1. CC chemokine ligand 25 enhances resistance to apoptosis in CD4+ T cells from patients with T-cell lineage acute and chronic lymphocytic leukemia by means of livin activation. Qiuping, Z., Jei, X., Youxin, J., Wei, J., Chun, L., Jin, W., Qun, W., Yan, L., Chunsong, H., Mingzhen, Y., Qingping, G., Kejian, Z., Zhimin, S., Qun, L., Junyan, L., Jinquan, T. Cancer Res. (2004) [Pubmed]
  2. The role of thymus-expressed chemokine and its receptor CCR9 on lymphocytes in the regional specialization of the mucosal immune system. Papadakis, K.A., Prehn, J., Nelson, V., Cheng, L., Binder, S.W., Ponath, P.D., Andrew, D.P., Targan, S.R. J. Immunol. (2000) [Pubmed]
  3. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Singh, S., Singh, U.P., Stiles, J.K., Grizzle, W.E., Lillard, J.W. Clin. Cancer Res. (2004) [Pubmed]
  4. CCR9-positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. Papadakis, K.A., Prehn, J., Moreno, S.T., Cheng, L., Kouroumalis, E.A., Deem, R., Breaverman, T., Ponath, P.D., Andrew, D.P., Green, P.H., Hodge, M.R., Binder, S.W., Targan, S.R. Gastroenterology (2001) [Pubmed]
  5. Hepatic endothelial CCL25 mediates the recruitment of CCR9+ gut-homing lymphocytes to the liver in primary sclerosing cholangitis. Eksteen, B., Grant, A.J., Miles, A., Curbishley, S.M., Lalor, P.F., Hübscher, S.G., Briskin, M., Salmon, M., Adams, D.H. J. Exp. Med. (2004) [Pubmed]
  6. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Vicari, A.P., Figueroa, D.J., Hedrick, J.A., Foster, J.S., Singh, K.P., Menon, S., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Bacon, K.B., Zlotnik, A. Immunity (1997) [Pubmed]
  7. CC chemokine ligands 25 and 28 play essential roles in intestinal extravasation of IgA antibody-secreting cells. Hieshima, K., Kawasaki, Y., Hanamoto, H., Nakayama, T., Nagakubo, D., Kanamaru, A., Yoshie, O. J. Immunol. (2004) [Pubmed]
  8. Functional CCR9 expression is associated with small intestinal metastasis. Letsch, A., Keilholz, U., Schadendorf, D., Assfalg, G., Asemissen, A.M., Thiel, E., Scheibenbogen, C. J. Invest. Dermatol. (2004) [Pubmed]
  9. Transient expression of CC chemokine TECK in the ovary during ovulation: its potential role in ovulation. Zhou, C., Wu, J., Borillo, J., Torres, L., McMahon, J., Bao, Y., Lou, Y.H. Am. J. Reprod. Immunol. (2005) [Pubmed]
  10. Cutting edge: identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. Zaballos, A., Gutiérrez, J., Varona, R., Ardavín, C., Márquez, G. J. Immunol. (1999) [Pubmed]
  11. Blocking of c-FLIP(L)--independent cycloheximide-induced apoptosis or Fas-mediated apoptosis by the CC chemokine receptor 9/TECK interaction. Youn, B.S., Kim, Y.J., Mantel, C., Yu, K.Y., Broxmeyer, H.E. Blood (2001) [Pubmed]
  12. The history of the College of Medicine and Tan Teck Guan Buildings. Teo, E.S. Ann. Acad. Med. Singap. (2005) [Pubmed]
  13. Nicotine use in early mediaeval Kirchheim/Teck, Germany. Balabanova, S., Rösing, F.W., Bühler, G., Hauser, S., Rosenthal, J. Homo : internationale Zeitschrift für die vergleichende Forschung am Menschen. (2001) [Pubmed]
  14. Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus. Itoi, M., Tsukamoto, N., Amagai, T. Int. Immunol. (2007) [Pubmed]
  15. Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. Kunkel, E.J., Campbell, J.J., Haraldsen, G., Pan, J., Boisvert, J., Roberts, A.I., Ebert, E.C., Vierra, M.A., Goodman, S.B., Genovese, M.C., Wardlaw, A.J., Greenberg, H.B., Parker, C.M., Butcher, E.C., Andrew, D.P., Agace, W.W. J. Exp. Med. (2000) [Pubmed]
  16. Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis. Zabel, B.A., Agace, W.W., Campbell, J.J., Heath, H.M., Parent, D., Roberts, A.I., Ebert, E.C., Kassam, N., Qin, S., Zovko, M., LaRosa, G.J., Yang, L.L., Soler, D., Butcher, E.C., Ponath, P.D., Parker, C.M., Andrew, D.P. J. Exp. Med. (1999) [Pubmed]
  17. Features and functions of gamma delta T lymphocytes: focus on chemokines and their receptors. Kabelitz, D., Wesch, D. Crit. Rev. Immunol. (2003) [Pubmed]
  18. Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL. Annels, N.E., Willemze, A.J., van der Velden, V.H., Faaij, C.M., van Wering, E., Sie-Go, D.M., Egeler, R.M., van Tol, M.J., Révész, T. Blood (2004) [Pubmed]
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