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Gene Review

AGPAT1  -  1-acylglycerol-3-phosphate O...

Homo sapiens

Synonyms: 1-AGP acyltransferase 1, 1-AGPAT 1, 1-AGPAT1, 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha, G15, ...
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Disease relevance of AGPAT1

  • 4. Human LPAAT-alpha and -beta isoforms were cloned and transfected into E. coli, demonstrating the ability to restore PA synthesis and reduce lyso-PA accumulation in plsC strains (LPAAT deficient mutants), as well as restoring growth at high temperatures [1].
  • RESULTS:: Both G5 and G15 showed concurrent recovery of r-CBF and BrT with hyperemia and hyperthermia, respectively, 10 to 15 minutes after reperfusion [2].
  • METHODS:: Eighteen Mongolian gerbils were assigned to one of three groups: 5-minute (G5), 15-minute (G15), or 30-minute (G30) ischemia [2].

High impact information on AGPAT1

  • Here we show that the C-terminal extension of the enzyme is not required for the selection of G15 as the site of base exchange; truncated forms of Pyrococcus furiosus TGT retain their specificity for guanine exchange at position 15 [3].
  • The present study in generation 15 (G15) female rats tested the hypothesis that continuing improvement in skeletal muscle O(2) transfer must be accompanied by augmentation in Qo(2 max) to support Vo(2 max) of HCR [4].
  • The greater G15 Qo(2 max) of HCR was due to a 48% greater stroke volume than LCR [4].
  • LPAAT-alpha mRNA was detected in all tissues with highest expression in skeletal muscle whereas LPAAT-beta was expressed predominantly in heart and liver tissues [5].
  • These results explain the susceptibility of E. coli and the resistance of human Jurkat cells to G15, and may have implications in designing membrane-selective therapeutic agents [6].

Biological context of AGPAT1


Anatomical context of AGPAT1

  • LPAAT-alpha mRNA is uniformly expressed throughout most tissues with the highest level found in skeletal muscle; whereas LPAAT-beta is differentially expressed, with the highest level found in heart and liver, and negligible level in brain and placenta [7].
  • However, G15 does not bind to lipid vesicles made of POPC/POPG/Chl (9:1:1) mixture, mimicking tumor cell membrane [6].

Analytical, diagnostic and therapeutic context of AGPAT1


  1. Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells. Bursten, S.L. Prog. Clin. Biol. Res. (1998) [Pubmed]
  2. Mismatch recovery of regional cerebral blood flow and brain temperature during reperfusion after prolonged brain ischemia in gerbils. Tajima, G., Shiozaki, T., Seiyama, A., Mohri, T., Kajino, K., Nakae, H., Tasaki, O., Ogura, H., Kuwagata, Y., Tanaka, H., Shimazu, T., Sugimoto, H. The Journal of trauma (2007) [Pubmed]
  3. The RNA-binding PUA domain of archaeal tRNA-guanine transglycosylase is not required for archaeosine formation. Sabina, J., Söll, D. J. Biol. Chem. (2006) [Pubmed]
  4. Continued divergence in VO2 max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. Gonzalez, N.C., Kirkton, S.D., Howlett, R.A., Britton, S.L., Koch, L.G., Wagner, H.E., Wagner, P.D. J. Appl. Physiol. (2006) [Pubmed]
  5. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. West, J., Tompkins, C.K., Balantac, N., Nudelman, E., Meengs, B., White, T., Bursten, S., Coleman, J., Kumar, A., Singer, J.W., Leung, D.W. DNA Cell Biol. (1997) [Pubmed]
  6. Cell selectivity correlates with membrane-specific interactions: a case study on the antimicrobial peptide G15 derived from granulysin. Ramamoorthy, A., Thennarasu, S., Tan, A., Lee, D.K., Clayberger, C., Krensky, A.M. Biochim. Biophys. Acta (2006) [Pubmed]
  7. The structure and functions of human lysophosphatidic acid acyltransferases. Leung, D.W. Front. Biosci. (2001) [Pubmed]
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