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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

DAOA-AS1  -  DAOA antisense RNA 1

Homo sapiens

Synonyms: DAOA-AS, DAOAAS, G30
 
 
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Disease relevance of G30

  • We conclude that both decreased insulin secretion (as assessed by low delta I30/delta G30) and increased insulin resistance (as assessed by fasting insulin) predict the development of NIDDM in Mexican-Americans, a group previously characterized as having hyperinsulinemia and insulin resistance.(ABSTRACT TRUNCATED AT 250 WORDS)[1]
  • Four enteropathogenic Escherichia coli (EPEC) strains belonging to the O55 serogroup (G21 and G30 [both O55:H6], G35 [O55:H-], and G58 [O55:H7]) were tested for their tissue tropism by using human intestinal in vitro organ culture [2].
  • METHODS:: Eighteen Mongolian gerbils were assigned to one of three groups: 5-minute (G5), 15-minute (G15), or 30-minute (G30) ischemia [3].
  • The immunogenicity of the constructs has been evaluated following both oral and intraperitoneal immunization of mice with the attenuated Salmonella typhimurium strain G30 harbouring the hybrid cst operons [4].
 

Psychiatry related information on G30

  • Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series [5].
  • Investigation of the DAOA/G30 locus in panic disorder [6].
  • Instead, our results imply that variation at the DAOA/G30 locus influences susceptibility to episodes of mood disorder across the traditional bipolar and schizophrenia categories [7].
 

High impact information on G30

  • DESIGN: A systematic study of polymorphisms at DAOA/G30 using genetic case-control association analysis [7].
  • CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consistency between studies of the tested polymorphisms or variants showing association [7].
  • Analysis of the decay of haplotype sharing gave a location estimate that included G72/G30 in its 95% confidence interval [5].
  • Further, when we stratified subjects by baseline glucose tolerance, both increased fasting insulin and decreased delta I30/delta G30 significantly predicted NIDDM in subjects with both impaired and normal glucose tolerance at baseline [1].
  • The authors therefore tested for association between DAOA/G30 and bipolar affective disorder in the 90 cases with a history of persecutory delusions [8].
 

Chemical compound and disease context of G30

  • As yet, there is no widely-accepted genetic association finding in mood disorders, but functional candidate genes, such as the serotonin transporter, and positional candidates, such as G72/G30 on chromosome 13q, are beginning to be identified in several studies [9].
  • These samples included lipids X and Y (monosaccharide precursors of lipid A) from Escherchia coli MN7; incomplete lipid A (a disaccharide precursor of lipid A) from Salmonella typhimurium i50; and monophosphoryl lipid A, TLC-3 (a derivative of LPS), from S. typhimurium G30/C21 [10].
 

Biological context of G30

  • Two overlapping genes G72 and G30 transcribed in brain were experimentally annotated in this 65-kb region [11].
  • METHODS: Eleven single nucleotide polymorphisms (SNPs) encompassing the G72/G30 genes were typed in the genomic deoxyribonucleic acid (DNA) from 60 schizophrenic patients and 130 matched control subjects of Ashkenazi ethnic origin [12].
  • We hypothesized that 1) polymorphic changes in this gene region might be associated with schizophrenia in the Ashkenazi Jewish population and that 2) changes in G72/G30 gene expression might be expected in schizophrenic patients compared with control subjects [12].
  • Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33 [13].
  • Recently, the nested genes G72 and G30 on chromosome 13q32-q33 have been implicated in the etiology of schizophrenia [14].
 

Anatomical context of G30

 

Associations of G30 with chemical compounds

  • It uses colloidal gold-labeled goat anti-mouse Ig (GAM G40 and GAM G30) as second layer and a methyl-green pyronin counterstain [16].
 

Physical interactions of G30

 

Analytical, diagnostic and therapeutic context of G30

References

  1. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Haffner, S.M., Miettinen, H., Gaskill, S.P., Stern, M.P. Diabetes (1995) [Pubmed]
  2. Tissue tropism of enteropathogenic Escherichia coli strains belonging to the O55 serogroup. Fitzhenry, R.J., Reece, S., Trabulsi, L.R., Heuschkel, R., Murch, S., Thomson, M., Frankel, G., Phillips, A.D. Infect. Immun. (2002) [Pubmed]
  3. Mismatch recovery of regional cerebral blood flow and brain temperature during reperfusion after prolonged brain ischemia in gerbils. Tajima, G., Shiozaki, T., Seiyama, A., Mohri, T., Kajino, K., Nakae, H., Tasaki, O., Ogura, H., Kuwagata, Y., Tanaka, H., Shimazu, T., Sugimoto, H. The Journal of trauma (2007) [Pubmed]
  4. Epitope analysis of the CS3 fimbrial subunit of human enterotoxigenic Escherichia coli and the construction of novel CS3::ST and CS3::LT-B immunogens. Yakhchali, B., Manning, P.A. Behring Inst. Mitt. (1997) [Pubmed]
  5. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. Hattori, E., Liu, C., Badner, J.A., Bonner, T.I., Christian, S.L., Maheshwari, M., Detera-Wadleigh, S.D., Gibbs, R.A., Gershon, E.S. Am. J. Hum. Genet. (2003) [Pubmed]
  6. Investigation of the DAOA/G30 locus in panic disorder. Schumacher, J., Abou Jamra, R., Becker, T., Klopp, N., Franke, P., Jacob, C., Sand, P., Fritze, J., Ohlraun, S., Schulze, T.G., Rietschel, M., Illig, T., Propping, P., Cichon, S., Deckert, J., Nöthen, M.M. Mol. Psychiatry (2005) [Pubmed]
  7. Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder. Williams, N.M., Green, E.K., Macgregor, S., Dwyer, S., Norton, N., Williams, H., Raybould, R., Grozeva, D., Hamshere, M., Zammit, S., Jones, L., Cardno, A., Kirov, G., Jones, I., O'Donovan, M.C., Owen, M.J., Craddock, N. Arch. Gen. Psychiatry (2006) [Pubmed]
  8. Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. Schulze, T.G., Ohlraun, S., Czerski, P.M., Schumacher, J., Kassem, L., Deschner, M., Gross, M., Tullius, M., Heidmann, V., Kovalenko, S., Jamra, R.A., Becker, T., Leszczynska-Rodziewicz, A., Hauser, J., Illig, T., Klopp, N., Wellek, S., Cichon, S., Henn, F.A., McMahon, F.J., Maier, W., Propping, P., Nöthen, M.M., Rietschel, M. The American journal of psychiatry. (2005) [Pubmed]
  9. Genetic association studies in mood disorders: issues and promise. Detera-Wadleigh, S.D., McMahon, F.J. International review of psychiatry (Abingdon, England) (2004) [Pubmed]
  10. Separation and characterization of toxic and nontoxic forms of lipid A. Takayama, K., Qureshi, N., Ribi, E., Cantrell, J.L. Rev. Infect. Dis. (1984) [Pubmed]
  11. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Chumakov, I., Blumenfeld, M., Guerassimenko, O., Cavarec, L., Palicio, M., Abderrahim, H., Bougueleret, L., Barry, C., Tanaka, H., La Rosa, P., Puech, A., Tahri, N., Cohen-Akenine, A., Delabrosse, S., Lissarrague, S., Picard, F.P., Maurice, K., Essioux, L., Millasseau, P., Grel, P., Debailleul, V., Simon, A.M., Caterina, D., Dufaure, I., Malekzadeh, K., Belova, M., Luan, J.J., Bouillot, M., Sambucy, J.L., Primas, G., Saumier, M., Boubkiri, N., Martin-Saumier, S., Nasroune, M., Peixoto, H., Delaye, A., Pinchot, V., Bastucci, M., Guillou, S., Chevillon, M., Sainz-Fuertes, R., Meguenni, S., Aurich-Costa, J., Cherif, D., Gimalac, A., Van Duijn, C., Gauvreau, D., Ouellette, G., Fortier, I., Raelson, J., Sherbatich, T., Riazanskaia, N., Rogaev, E., Raeymaekers, P., Aerssens, J., Konings, F., Luyten, W., Macciardi, F., Sham, P.C., Straub, R.E., Weinberger, D.R., Cohen, N., Cohen, D., Ouelette, G., Realson, J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  12. Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. Korostishevsky, M., Kaganovich, M., Cholostoy, A., Ashkenazi, M., Ratner, Y., Dahary, D., Bernstein, J., Bening-Abu-Shach, U., Ben-Asher, E., Lancet, D., Ritsner, M., Navon, R. Biol. Psychiatry (2004) [Pubmed]
  13. Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33. Chen, Y.S., Akula, N., Detera-Wadleigh, S.D., Schulze, T.G., Thomas, J., Potash, J.B., DePaulo, J.R., McInnis, M.G., Cox, N.J., McMahon, F.J. Mol. Psychiatry (2004) [Pubmed]
  14. Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations. Ma, J., Qin, W., Wang, X.Y., Guo, T.W., Bian, L., Duan, S.W., Li, X.W., Zou, F.G., Fang, Y.R., Fang, J.X., Feng, G.Y., Gu, N.F., St Clair, D., He, L. Mol. Psychiatry (2006) [Pubmed]
  15. Electro-acupuncture attenuates behavioral hyperalgesia and selectively reduces spinal Fos protein expression in rats with persistent inflammation. Lao, L., Zhang, G., Wei, F., Berman, B.M., Ren, K. The journal of pain : official journal of the American Pain Society. (2001) [Pubmed]
  16. Immunogold staining: an alternative method for lymphocyte subset enumeration. Comparison with immunofluorescence microscopy and flow cytometry. Wybran, J., Rosenberg, J., Romasco, F. J. Immunol. Methods (1985) [Pubmed]
  17. G72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Detera-Wadleigh, S.D., McMahon, F.J. Biol. Psychiatry (2006) [Pubmed]
  18. Family-based association study between G72/G30 genetic polymorphism and schizophrenia. Hong, C.J., Hou, S.J., Yen, F.C., Liou, Y.J., Tsai, S.J. Neuroreport (2006) [Pubmed]
  19. Contribution of insulin-stimulated glucose uptake and basal hepatic insulin sensitivity to surrogate measures of insulin sensitivity. Tripathy, D., Almgren, P., Tuomi, T., Groop, L. Diabetes Care (2004) [Pubmed]
 
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