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Gene Review

nifA  -  nif-specific regulatory protein

Bradyrhizobium diazoefficiens USDA 110

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Disease relevance of nifA


High impact information on nifA

  • The nucleotide sequence of the Azorhizobium caulinodans ORS571 nifA locus was determined and the deduced NifA amino acid sequence compared with that of NifA from other nitrogen-fixing species [2].
  • Expression of the fixR-nifA operon in Bradyrhizobium japonicum depends on a new response regulator, RegR [4].
  • Similarly, regR mutants showed only about 2% residual nitrogen fixation activity, but unlike nodules induced by nifA mutants, the morphology of those nodules was normal, displaying no signs of necrosis [4].
  • NifA is encoded in the fixR-nifA operon, which is expressed at a low level under aerobic conditions and induced approximately fivefold under low-oxygen tension [4].
  • A chromosomal deletion of the upstream activator sequence (UAS) led to a symbiotically defective phenotype which was typical of nifA mutants [5].

Biological context of nifA


Regulatory relationships of nifA

  • The nifA genes thus expressed led to a marked activation of a B. japonicum nifD-lacZ fusion under microaerobic conditions [1].


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