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Gene Review

Phyhip  -  phytanoyl-CoA hydroxylase interacting protein

Mus musculus

Synonyms: AW049870, C630010D02Rik, Lnap1ip, PAHX-AP#1, PAHX-AP1, ...
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Disease relevance of Phyhip


High impact information on Phyhip

  • Previously, we identified a novel neuron-specific protein (PAHX-AP1) that binds to Refsum disease gene product (PAHX), and we developed transgenic (TG) mice that overexpress heart-targeted PAHX-AP1 [3].
  • Propranolol pretreatment, a non-specific beta-adrenoceptor antagonist, blocked aconitine-induced arrhythmia in non-TG mice, but not in PAHX-AP1 TG mice [3].
  • RT-PCR analyses revealed that the cardiac expression of adrenergic beta(1)-receptor (ADRB1) was markedly lower, whereas voltage-gated potassium channel expression (Kv2.1) was higher in PAHX-AP1 TG mice compared with non-TG mice [3].
  • In this report, we developed heart-targeted transgenic (TG) mice under the control of alpha-myosin heavy chain promoter to determine whether cardiac overexpression of PAHX-AP1 provokes cardiac involvement symptoms [4].
  • Northern and in situ hybridization analyses revealed PAHX-AP1 transcript was overexpressed in TG atrium, especially in the sinoatrial node [4].

Other interactions of Phyhip


  1. Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. Koh, J.T., Lee, Z.H., Ahn, K.Y., Kim, J.K., Bae, C.S., Kim, H.H., Kee, H.J., Kim, K.K. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  2. Identification of a brain specific protein that associates with a refsum disease gene product, phytanoyl-CoA alpha-hydroxylase. Lee, Z.H., Kim, H., Ahn, K.Y., Seo, K.H., Kim, J.K., Bae, C.S., Kim, K.K. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  3. Changes underlying arrhythmia in the transgenic heart overexpressing Refsum disease gene-associated protein. Koh, J.T., Jeong, B.C., Kim, J.H., Ahn, Y.K., Lee, H.S., Baik, Y.H., Kim, K.K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  4. Cardiac Characteristics of Transgenic Mice Overexpressing Refsum Disease Gene-Associated Protein within the Heart. Koh, J.T., Choi, H.H., Ahn, K.Y., Kim, J.U., Kim, J.H., Chun, J.Y., Baik, Y.H., Kim, K.K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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