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TRIM16  -  tripartite motif containing 16

Homo sapiens

Synonyms: EBBP, Estrogen-responsive B box protein, Tripartite motif-containing protein 16
 
 
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High impact information on TRIM16

 

Biological context of TRIM16

  • In HMEC stably transfected with an ER mutant containing a deletion in the second zinc finger of the DNA-binding domain, E and HT had different effects on EBBP gene expression; EBBP regulation by E was dramatically reduced while the effects of HT were augmented [2].
 

Associations of TRIM16 with chemical compounds

  • Studies of the estrogenic regulation of EBBP expression demonstrated that the E-dependent increase in EBBP mRNA levels in the ER-transfected HMEC is an early, ER-mediated, and cycloheximide-insensitive process [2].
  • These genes were two aldo-keto reductases (AKR1C1 and AKR1C2) and an estrogen-responsive gene (EBBP) [3].
 

Other interactions of TRIM16

  • These data indicate that HT can modulate EBBP mRNA expression through a mutated ER, which has little activity when bound by E, and suggest that different molecular mechanisms control the E and HT responsiveness of the EBBP gene [2].
  • EBBP was secreted in a caspase-1-dependent manner from cultured cells, and its secretion was enhanced by IL-1beta [4].

References

  1. The estrogen-responsive B box protein is a novel regulator of the retinoid signal. Cheung, B.B., Bell, J., Raif, A., Bohlken, A., Yan, J., Roediger, B., Poljak, A., Smith, S., Lee, M., Thomas, W.D., Kavallaris, M., Norris, M., Haber, M., Liu, H.L., Zajchowski, D., Marshall, G.M. J. Biol. Chem. (2006) [Pubmed]
  2. The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant. Liu, H.L., Golder-Novoselsky, E., Seto, M.H., Webster, L., McClary, J., Zajchowski, D.A. Mol. Endocrinol. (1998) [Pubmed]
  3. Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Gwinn, M.R., Whipkey, D.L., Tennant, L.B., Weston, A. Environ. Health Perspect. (2005) [Pubmed]
  4. The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Munding, C., Keller, M., Niklaus, G., Papin, S., Tschopp, J., Werner, S., Beer, H.D. Cell Death Differ. (2006) [Pubmed]
 
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