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Gene Review

CASP1  -  caspase 1, apoptosis-related cysteine...

Homo sapiens

Synonyms: CASP-1, Caspase-1, ICE, IL-1 beta-converting enzyme, IL-1BC, ...
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Disease relevance of CASP1


Psychiatry related information on CASP1

  • The increase in amplitude of P45 and N60 in MLSEPs seems to be characteristically associated with normal aging and the development of dementia [6].

High impact information on CASP1


Chemical compound and disease context of CASP1


Biological context of CASP1


Anatomical context of CASP1


Associations of CASP1 with chemical compounds


Physical interactions of CASP1


Enzymatic interactions of CASP1


Regulatory relationships of CASP1


Other interactions of CASP1


Analytical, diagnostic and therapeutic context of CASP1


  1. Haplotypes of the caspase-1 gene, plasma caspase-1 levels, and cardiovascular risk. Blankenberg, S., Godefroy, T., Poirier, O., Rupprecht, H.J., Barbaux, S., Bickel, C., Nicaud, V., Schnabel, R., Kee, F., Morrison, C., Evans, A., Lackner, K.J., Cambien, F., Münzel, T., Tiret, L. Circ. Res. (2006) [Pubmed]
  2. Inhibition of interleukin 1 beta-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP. Hawkins, C.J., Uren, A.G., Häcker, G., Medcalf, R.L., Vaux, D.L. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. DNA fragmentation induced by protease activation in p53-null human leukemia HL60 cells undergoing apoptosis following treatment with the topoisomerase I inhibitor camptothecin: cell-free system studies. Shimizu, T., Pommier, Y. Exp. Cell Res. (1996) [Pubmed]
  4. Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease. McAlindon, M.E., Hawkey, C.J., Mahida, Y.R. Gut (1998) [Pubmed]
  5. Up-regulation of the Nedd2 gene encoding an ICE/Ced-3-like cysteine protease in the gerbil brain after transient global ischemia. Kinoshita, M., Tomimoto, H., Kinoshita, A., Kumar, S., Noda, M. J. Cereb. Blood Flow Metab. (1997) [Pubmed]
  6. Scalp topographic mapping of middle-latency somatosensory evoked potentials in normal aging and dementia. Ferri, R., Del Gracco, S., Elia, M., Musumeci, S.A., Spada, R., Stefanini, M.C. Neurophysiologie clinique = Clinical neurophysiology. (1996) [Pubmed]
  7. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Chinnaiyan, A.M., O'Rourke, K., Tewari, M., Dixit, V.M. Cell (1995) [Pubmed]
  8. Crystal structure of the cysteine protease interleukin-1 beta-converting enzyme: a (p20/p10)2 homodimer. Walker, N.P., Talanian, R.V., Brady, K.D., Dang, L.C., Bump, N.J., Ferenz, C.R., Franklin, S., Ghayur, T., Hackett, M.C., Hammill, L.D. Cell (1994) [Pubmed]
  9. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nicholson, D.W., Ali, A., Thornberry, N.A., Vaillancourt, J.P., Ding, C.K., Gallant, M., Gareau, Y., Griffin, P.R., Labelle, M., Lazebnik, Y.A. Nature (1995) [Pubmed]
  10. Apoptosis and the cell cycle. Evan, G.I., Brown, L., Whyte, M., Harrington, E. Curr. Opin. Cell Biol. (1995) [Pubmed]
  11. Apoptosis: lessons from in vitro systems. Earnshaw, W.C. Trends Cell Biol. (1995) [Pubmed]
  12. Interleukin-1 beta-converting enzyme mediates cisplatin-induced apoptosis in malignant glioma cells. Kondo, S., Barna, B.P., Morimura, T., Takeuchi, J., Yuan, J., Akbasak, A., Barnett, G.H. Cancer Res. (1995) [Pubmed]
  13. Characterization of a breast cancer cell differentiation factor that specifically activates the HER4/p180erbB4 receptor. Culouscou, J.M., Plowman, G.D., Carlton, G.W., Green, J.M., Shoyab, M. J. Biol. Chem. (1993) [Pubmed]
  14. Ceramides induce a form of apoptosis in human acute lymphoblastic leukemia cells that is inhibited by Bcl-2, but not by CrmA. Geley, S., Hartmann, B.L., Kofler, R. FEBS Lett. (1997) [Pubmed]
  15. Hepatitis B e antigen polypeptides isolated from sera of individuals infected with hepatitis B virus: comparison with HBeAg polypeptide derived from Dane particles. Takahashi, K., Imai, M., Gotanda, T., Sano, T., Oinuma, A., Mishiro, S., Miyakawa, Y., Mayumi, M. J. Gen. Virol. (1980) [Pubmed]
  16. A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells. Faucheu, C., Diu, A., Chan, A.W., Blanchet, A.M., Miossec, C., Hervé, F., Collard-Dutilleul, V., Gu, Y., Aldape, R.A., Lippke, J.A. EMBO J. (1995) [Pubmed]
  17. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. Lippke, J.A., Gu, Y., Sarnecki, C., Caron, P.R., Su, M.S. J. Biol. Chem. (1996) [Pubmed]
  18. Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. Droin, N., Dubrez, L., Eymin, B., Renvoizé, C., Bréard, J., Dimanche-Boitrel, M.T., Solary, E. Oncogene (1998) [Pubmed]
  19. Molecular characterization of the gene for human interleukin-1 beta converting enzyme (IL1BC). Cerretti, D.P., Hollingsworth, L.T., Kozlosky, C.J., Valentine, M.B., Shapiro, D.N., Morris, S.W., Nelson, N. Genomics (1994) [Pubmed]
  20. Caspase-1zeta, a new splice variant of the caspase-1 gene. Feng, Q., Li, P., Leung, P.C., Auersperg, N. Genomics (2004) [Pubmed]
  21. Resistance of cultured peripheral T cells towards activation-induced cell death involves a lack of recruitment of FLICE (MACH/caspase 8) to the CD95 death-inducing signaling complex. Peter, M.E., Kischkel, F.C., Scheuerpflug, C.G., Medema, J.P., Debatin, K.M., Krammer, P.H. Eur. J. Immunol. (1997) [Pubmed]
  22. Cloning and expression of four novel isoforms of human interleukin-1 beta converting enzyme with different apoptotic activities. Alnemri, E.S., Fernandes-Alnemri, T., Litwack, G. J. Biol. Chem. (1995) [Pubmed]
  23. CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. Schlegel, J., Peters, I., Orrenius, S., Miller, D.K., Thornberry, N.A., Yamin, T.T., Nicholson, D.W. J. Biol. Chem. (1996) [Pubmed]
  24. Interleukin 1 beta (IL-1 beta) processing in murine macrophages requires a structurally conserved homologue of human IL-1 beta converting enzyme. Molineaux, S.M., Casano, F.J., Rolando, A.M., Peterson, E.P., Limjuco, G., Chin, J., Griffin, P.R., Calaycay, J.R., Ding, G.J., Yamin, T.T. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  25. Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway. Dbaibo, G.S., Perry, D.K., Gamard, C.J., Platt, R., Poirier, G.G., Obeid, L.M., Hannun, Y.A. J. Exp. Med. (1997) [Pubmed]
  26. Pivotal role of a DEVD-sensitive step in etoposide-induced and Fas-mediated apoptotic pathways. Dubrez, L., Savoy, I., Hamman, A., Solary, E. EMBO J. (1996) [Pubmed]
  27. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Xiang, J., Chao, D.T., Korsmeyer, S.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  28. Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains. Wang, X., Pai, J.T., Wiedenfeld, E.A., Medina, J.C., Slaughter, C.A., Goldstein, J.L., Brown, M.S. J. Biol. Chem. (1995) [Pubmed]
  29. Production, purification, and crystallization of human interleukin-1 beta converting enzyme derived from an Escherichia coli expression system. Malinowski, J.J., Grasberger, B.L., Trakshel, G., Huston, E.E., Helaszek, C.T., Smallwood, A.M., Ator, M.A., Banks, T.M., Brake, P.G., Ciccarelli, R.B. Protein Sci. (1995) [Pubmed]
  30. Deficient brain snRNP70K in patients with Down syndrome. Seidl, R., Labudova, O., Krapfenbauer, K., Henriksson, E.W., Craft, J., Turhani-Schatzmann, D., Achsel, T., Bidmon, B., Pruijn, G.J., Cairns, N., Lubec, G. Electrophoresis (2001) [Pubmed]
  31. Lamin proteolysis facilitates nuclear events during apoptosis. Rao, L., Perez, D., White, E. J. Cell Biol. (1996) [Pubmed]
  32. The IL-1 beta-converting enzyme (caspase-1) inhibits apoptosis of inflammatory neutrophils through activation of IL-1 beta. Watson, R.W., Rotstein, O.D., Parodo, J., Bitar, R., Marshall, J.C., William, R., Watson, G. J. Immunol. (1998) [Pubmed]
  33. Induction of IL-1 beta-converting enzyme-independent apoptosis by IL-2 in human T cell lines. Oda, K., Asao, H., Higuchi, M., Tanaka, N., Moffatt, S., Nakamura, M., Tabayashi, K., Sugamura, K. Int. Immunol. (1997) [Pubmed]
  34. Interleukin-1 beta converting enzyme-like protease involvement in Fas-induced and activation-induced peripheral blood T cell apoptosis in HIV infection. TNF-related apoptosis-inducing ligand can mediate activation-induced T cell death in HIV infection. Katsikis, P.D., Garcia-Ojeda, M.E., Torres-Roca, J.F., Tijoe, I.M., Smith, C.A., Herzenberg, L.A., Herzenberg, L.A. J. Exp. Med. (1997) [Pubmed]
  35. Comparison of performance in successive CASP experiments. Venclovas, C., Zemla, A., Fidelis, K., Moult, J. Proteins (2001) [Pubmed]
  36. Overexpression of MDR1 using a retroviral vector differentially regulates genes involved in detoxification and apoptosis and confers radioprotection. Maier, P., Fleckenstein, K., Li, L., Laufs, S., Zeller, W.J., Baum, C., Fruehauf, S., Herskind, C., Wenz, F. Radiat. Res. (2006) [Pubmed]
  37. Role of interleukin-1 beta converting enzyme (ICE) in leukemia. Estrov, Z., Talpaz, M. Cytokines and molecular therapy. (1996) [Pubmed]
  38. Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2. Gu, Y., Sarnecki, C., Aldape, R.A., Livingston, D.J., Su, M.S. J. Biol. Chem. (1995) [Pubmed]
  39. Molecular cloning of the interleukin-1 beta converting enzyme. Cerretti, D.P., Kozlosky, C.J., Mosley, B., Nelson, N., Van Ness, K., Greenstreet, T.A., March, C.J., Kronheim, S.R., Druck, T., Cannizzaro, L.A. Science (1992) [Pubmed]
  40. The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. Singer, I.I., Scott, S., Chin, J., Bayne, E.K., Limjuco, G., Weidner, J., Miller, D.K., Chapman, K., Kostura, M.J. J. Exp. Med. (1995) [Pubmed]
  41. IL-1 beta-converting enzyme (ICE) is present and functional in human alveolar macrophages: macrophage IL-1 beta release limitation is ICE independent. Wewers, M.D., Dare, H.A., Winnard, A.V., Parker, J.M., Miller, D.K. J. Immunol. (1997) [Pubmed]
  42. Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells. Yang, P., McKay, B.S., Allen, J.B., Jaffe, G.J. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  43. Association of bcl-2, bax, bcl-xL and interleukin-1 beta-converting enzyme expression with initial response to chemotherapy in acute myeloid leukemia. Stoetzer, O.J., Nüssler, V., Darsow, M., Gullis, E., Pelka-Fleischer, R., Scheel, U., Wilmanns, W. Leukemia (1996) [Pubmed]
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