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Gene Review

SFRP4  -  secreted frizzled-related protein 4

Homo sapiens

Synonyms: FRP-4, FRPHE, Frizzled protein, human endometrium, FrpHE, Secreted frizzled-related protein 4, ...
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Disease relevance of SFRP4

  • Here, we report that silencing of SFRP4 is correlated with promoter hypermethylation in beta-catenin-deficient mesothelioma cell lines [1].
  • Compared with normal endometrium, the expression of SFRP4 was decreased in both low-grade endometrial stromal sarcoma (ESS; n = 10) and undifferentiated endometrial sarcoma (UES; n = 4), being lower in the latter more aggressive form [2].
  • Furthermore, the expression of beta-catenin, an important component of the Wnt-signalling pathway, was regulated in an opposite manner to SFRP4, being particularly increased in undifferentiated sarcomas [2].
  • Thus, sFRP-4 displays phosphatonin-like properties, because it is a circulating protein that promotes phosphaturia and hypophosphatemia and blunts compensatory increases in 1alpha, 25-dihydroxyvitamin D [3].
  • The sFRP-4 is detectable in normal human serum and in the serum of a patient with tumor-induced osteomalacia [3].

High impact information on SFRP4


Chemical compound and disease context of SFRP4


Biological context of SFRP4


Anatomical context of SFRP4


Other interactions of SFRP4


Analytical, diagnostic and therapeutic context of SFRP4


  1. Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells. He, B., Lee, A.Y., Dadfarmay, S., You, L., Xu, Z., Reguart, N., Mazieres, J., Mikami, I., McCormick, F., Jablons, D.M. Cancer Res. (2005) [Pubmed]
  2. Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas. Hrzenjak, A., Tippl, M., Kremser, M.L., Strohmeier, B., Guelly, C., Neumeister, D., Lax, S., Moinfar, F., Tabrizi, A.D., Isadi-Moud, N., Zatloukal, K., Denk, H. J. Pathol. (2004) [Pubmed]
  3. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. Berndt, T., Craig, T.A., Bowe, A.E., Vassiliadis, J., Reczek, D., Finnegan, R., Jan De Beur, S.M., Schiavi, S.C., Kumar, R. J. Clin. Invest. (2003) [Pubmed]
  4. The roles of specific genes implicated as circulating factors involved in normal and disordered phosphate homeostasis: frizzled related protein-4, matrix extracellular phosphoglycoprotein, and fibroblast growth factor 23. White, K.E., Larsson, T.E., Econs, M.J. Endocr. Rev. (2006) [Pubmed]
  5. CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia. Liu, T.H., Raval, A., Chen, S.S., Matkovic, J.J., Byrd, J.C., Plass, C. Cancer Res. (2006) [Pubmed]
  6. Radiation hybrid mapping of genes in the lithium-sensitive wnt signaling pathway. Rhoads, A.R., Karkera, J.D., Detera-Wadleigh, S.D. Mol. Psychiatry (1999) [Pubmed]
  7. The phosphatonins and the regulation of phosphate transport and vitamin D metabolism. Sommer, S., Berndt, T., Craig, T., Kumar, R. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
  8. FGF-23 and sFRP-4 in chronic kidney disease and post-renal transplantation. Pande, S., Ritter, C.S., Rothstein, M., Wiesen, K., Vassiliadis, J., Kumar, R., Schiavi, S.C., Slatapolsky, E., Brown, A.J. Nephron. Physiology [electronic resource]. (2006) [Pubmed]
  9. Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Martinez, I., Wang, J., Hobson, K.F., Ferris, R.L., Khan, S.A. Eur. J. Cancer (2007) [Pubmed]
  10. Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro. Horvath, L.G., Henshall, S.M., Kench, J.G., Saunders, D.N., Lee, C.S., Golovsky, D., Brenner, P.C., O'Neill, G.F., Kooner, R., Stricker, P.D., Grygiel, J.J., Sutherland, R.L. Clin. Cancer Res. (2004) [Pubmed]
  11. Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy. Abu-Jawdeh, G., Comella, N., Tomita, Y., Brown, L.F., Tognazzi, K., Sokol, S.Y., Kocher, O. Lab. Invest. (1999) [Pubmed]
  12. Phosphate diabetes, tubular phosphate reabsorption and phosphatonins. Laroche, M., Boyer, J.F. Joint, bone, spine : revue du rhumatisme. (2005) [Pubmed]
  13. Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells. Berndt, T.J., Bielesz, B., Craig, T.A., Tebben, P.J., Bacic, D., Wagner, C.A., O'Brien, S., Schiavi, S., Biber, J., Murer, H., Kumar, R. Pflugers Arch. (2006) [Pubmed]
  14. Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus. Zou, H., Molina, J.R., Harrington, J.J., Osborn, N.K., Klatt, K.K., Romero, Y., Burgart, L.J., Ahlquist, D.A. Int. J. Cancer (2005) [Pubmed]
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