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Gene Review

Grm3  -  glutamate receptor, metabotropic 3

Mus musculus

Synonyms: 0710001G23Rik, Gprc1c, Metabotropic glutamate receptor 3, Mglur3, mGlu3, ...
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Psychiatry related information on Grm3

  • Previous studies indicate that agonists of the group II metabotropic glutamate receptors (mGluRs), mGluR2 and mGluR3, may provide a novel approach for the treatment of anxiety disorders and schizophrenia [1].

High impact information on Grm3

  • These results suggest that mGluR2 or mGluR3 receptors suppress the activity of L-type Ca2+ channels by a mechanism involving Gi or G(o) proteins [2].
  • This mGluR has a pharmacological profile similar to that of mGluR3, because quisqualate is active at relatively low concentrations (EC50 < 100 microM) [3].
  • The enzyme N-acetylated-alpha-linked acidic dipeptidase (NAALADase) hydrolyzes the neurotransmitter N-acetylaspartylglutamate (NAAG) to form glutamate and N-acetylaspartate; NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release [4].
  • Double labeling revealed that the vast majority of mGluR3 in presynaptic elements is not closely associated with glutamate and GABA release sites in the striatum and thalamus, respectively [5].
  • Upon neurostimulation, NAAG is exported to astrocytes where it activates a specific metabotropic Glu surface receptor (mGluR3), and is then hydrolyzed by an astrocyte-specific enzyme, NAAG peptidase, liberating Glu, which can then be taken up by the astrocyte [6].

Biological context of Grm3


Anatomical context of Grm3

  • We have characterized the structural organization of the mouse mGluR3 gene by genomic cloning in combination with rapid amplification of 5'- and 3'-cDNA ends and examined regulatory expression of mGluR3 mRNA in cultured cortical astrocytes [7].

Associations of Grm3 with chemical compounds

  • Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites [5].

Other interactions of Grm3

  • However, the relative contributions of the mGluR2 and mGluR3 subtypes to the effects of the group II mGluR agonists remain unclear [1].

Analytical, diagnostic and therapeutic context of Grm3

  • In order to determine if such a distribution is common to another group II subtype, mGluR3, an antibody was raised against a carboxy-terminus of mGluR3 and used for light and electron microscopic immunohistochemistry in the mouse CNS [5].


  1. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. Galici, R., Jones, C.K., Hemstapat, K., Nong, Y., Echemendia, N.G., Williams, L.C., de Paulis, T., Conn, P.J. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  2. The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. Chavis, P., Shinozaki, H., Bockaert, J., Fagni, L. J. Neurosci. (1994) [Pubmed]
  3. Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures. Prézeau, L., Carrette, J., Helpap, B., Curry, K., Pin, J.P., Bockaert, J. Mol. Pharmacol. (1994) [Pubmed]
  4. Reduced isolation-induced aggressiveness in mice following NAALADase inhibition. Lumley, L.A., Robison, C.L., Slusher, B.S., Wozniak, K., Dawood, M., Meyerhoff, J.L. Psychopharmacology (Berl.) (2004) [Pubmed]
  5. Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites. Tamaru, Y., Nomura, S., Mizuno, N., Shigemoto, R. Neuroscience (2001) [Pubmed]
  6. 2-PMPA, a NAAG peptidase inhibitor, attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia. Baslow, M.H., Dyakin, V.V., Nowak, K.L., Hungund, B.L., Guilfoyle, D.N. J. Mol. Neurosci. (2005) [Pubmed]
  7. Structural organization of the mouse metabotropic glutamate receptor subtype 3 gene and its regulation by growth factors in cultured cortical astrocytes. Minoshima, T., Nakanishi, S. J. Biochem. (1999) [Pubmed]
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