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Gene Review:

Etlm1 - ethanol induced locomotion 1

Mus musculus

Pastor, R. et al., Meyer, P.J. et al., Holstein, S.E. et al., Font, L. et al., Manrique, H.M. et al., et al.

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High impact information on Etlm1

The prevention of 3-NPA effects on both ethanol-induced locomotion and brain catalase activity by l-carnitine, a potent antioxidant, was also studied [1].
OBJECTIVE: To evaluate a possible common mechanism for these traits, we examined the effect of naloxone, an opioid receptor antagonist, on ethanol- and morphine-induced locomotion in FAST and SLOW mice, as well as on ethanol-induced locomotion in two heterogeneous stocks of mice [2].
CONCLUSIONS: The present results suggest that an increase in brain H(2)O(2) production potentiates ethanol-induced locomotion [3].
OBJECTIVES: The aim of the present study was to assess if the enhancement of cerebral H(2)O(2) production after hyperoxia exposure results in a boost of ethanol-induced locomotion in mice [3].
METHODS: CD-1 mice were exposed to air or 99.5% O(2) inhalation (for 15, 30, or 45 min) and 0, 30, 60 or 120 min after this treatment, ethanol-induced locomotion was measured [3].

Anatomical context of Etlm1

Consequences of monosodium glutamate or goldthioglucose arcuate nucleus lesions on ethanol-induced locomotion [4].

Associations of Etlm1 with chemical compounds

Two initial studies characterized ketamine-induced locomotion in DBA/2J (D2) mice, an inbred strain chosen for its high sensitivity to ethanol-induced locomotion [5].
Previous studies have suggested that differences in N-methyl-d-aspartate (NMDA) receptors may underlie differences in ethanol-induced locomotion in these mice [5].
Lession on the hypothalamic arcuate nucleus by estradiol valerate results in a blockade of ethanol-induced locomotion [6].
In order to evaluate the effect of hypotaurine on ethanol-induced locomotion, different groups of mice received an injection of saline or 5.62, 8.45, 11.25, 16.87 or 33.75 mg/kg of hypotaurine 30 min prior to administering ethanol (2.4 g/kg) [7].
Lead acetate potentiates brain catalase activity and enhances ethanol-induced locomotion in mice [8].

Other interactions of Etlm1

The involvement of catalase in ethanol-induced locomotion has been clearly proven [9].

References

Acute administration of 3-nitropropionic acid, a reactive oxygen species generator, boosts ethanol-induced locomotor stimulation. New support for the role of brain catalase in the behavioural effects of ethanol. Manrique, H.M., Miquel, M., Aragon, C.M. Neuropharmacology (2006) [Pubmed]
Naloxone does not attenuate the locomotor effects of ethanol in FAST, SLOW, or two heterogeneous stocks of mice. Holstein, S.E., Pastor, R., Meyer, P.J., Phillips, T.J. Psychopharmacology (Berl.) (2005) [Pubmed]
Ethanol-stimulated behaviour in mice is modulated by brain catalase activity and H2O2 rate of production. Pastor, R., Sanchis-Segura, C., Aragon, C.M. Psychopharmacology (Berl.) (2002) [Pubmed]
Consequences of monosodium glutamate or goldthioglucose arcuate nucleus lesions on ethanol-induced locomotion. Sanchis-Segura, C., Aragon, C.M. Drug and alcohol dependence. (2002) [Pubmed]
Sensitivity to ketamine, alone or in combination with ethanol, is altered in mice selectively bred for sensitivity to ethanol's locomotor effects. Meyer, P.J., Phillips, T.J. Alcohol. Clin. Exp. Res. (2003) [Pubmed]
Lession on the hypothalamic arcuate nucleus by estradiol valerate results in a blockade of ethanol-induced locomotion. Sanchis-Segura, C., Correa, M., Aragon, C.M. Behav. Brain Res. (2000) [Pubmed]
Behavioral consequences of the hypotaurine-ethanol interaction. Font, L., Miquel, M., Aragon, C.M. Pharmacol. Biochem. Behav. (2001) [Pubmed]
Lead acetate potentiates brain catalase activity and enhances ethanol-induced locomotion in mice. Correa, M., Miquel, M., Aragon, C.M. Pharmacol. Biochem. Behav. (2000) [Pubmed]
Brain catalase mediates potentiation of social recognition memory produced by ethanol in mice. Manrique, H.M., Miquel, M., Aragon, C.M. Drug and alcohol dependence. (2005) [Pubmed]

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