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Gene Review:

SLC27A3 - solute carrier family 27 (fatty acid...

Homo sapiens

Synonyms: ACSVL3, FATP-3, FATP3, Fatty acid transport protein 3, Long-chain fatty acid transport protein 3, ...

Pei, Z. et al., Calvo, J.H. et al., Calvo, J.H. et al.

Calvo, Martínez-Royo, Beattie, Dodds, Marcos-Carcavilla, Serrano, Calvo, Martínez-Royo, Silveri, Floriot, Eggen, Marcos-Carcavilla, Serrano,

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High impact information on SLC27A3

In MA-10 cells, loss-of-function studies using RNA interference confirmed that endogenous ACSVL3 is an acyl-CoA synthetase capable of activating both long-chain (C16:0) and very long-chain (C24:0) fatty acids [1].
Endogenous ACSVL3 was found primarily in mitochondria of MA-10 and Neuro2a cells by both Western blot analysis of subcellular fractions and immunofluorescence analysis [1].
Immunohistochemistry revealed high ACSVL3 expression in adrenal cortical cells, spermatocytes and interstitial cells of the testis, theca cells of the ovary, cerebral cortical neurons, and cerebellar Purkinje cells [1].
DNA fragments of 1931 and 2790 bp corresponding to ANXA9 and SLC27A3 respectively were isolated, and 14 and 6 single nucleotide polymorphisms (SNPs) respectively were found in each gene [2].
Finally, ACP6,CGN,ANXA9 and SLC27A3 genes were located on chromosome 3 between ILSTS096 and BMS819 markers, in a region in which quantitative trait loci (QTL) for several milk traits have been described [3].

Biological context of SLC27A3

On the basis of comparative mapping between cattle/sheep and human for milk trait quantitative trait loci (QTL) on BTA3/OAR1, annexin A9 (ANXA9) and solute carrier family 27 (fatty acid transporter), member 3 (SLC27A3) were selected as candidate genes for fat content (FC) in sheep milk [2].

Analytical, diagnostic and therapeutic context of SLC27A3

Direct sequencing of PCR products amplified from different cattle breeds revealed 1, 4, 4 and 2 SNPs for ACP6, CGN,ANXA9 and SLC27A3, respectively [3].

References

Mouse very long-chain Acyl-CoA synthetase 3/fatty acid transport protein 3 catalyzes fatty acid activation but not fatty acid transport in MA-10 cells. Pei, Z., Fraisl, P., Berger, J., Jia, Z., Forss-Petter, S., Watkins, P.A. J. Biol. Chem. (2004) [Pubmed]
Fine mapping of genes on sheep chromosome 1 and their association with milk traits. Calvo, J.H., Martínez-Royo, A., Beattie, A.E., Dodds, K.G., Marcos-Carcavilla, A., Serrano, M. Anim. Genet. (2006) [Pubmed]
Isolation, mapping and identification of SNPs for four genes (ACP6, CGN, ANXA9, SLC27A3) from a bovine QTL region on BTA3. Calvo, J.H., Martínez-Royo, A., Silveri, L., Floriot, S., Eggen, A., Marcos-Carcavilla, A., Serrano, M. Cytogenet. Genome Res. (2006) [Pubmed]

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