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Gene Review

Cyp11b1  -  cytochrome P450, family 11, subfamily b,...

Mus musculus

Synonyms: AA389061, CPN1, Cyp11b, Cyp11b-1, FHI
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High impact information on Cyp11b1

  • Clonal lines with different levels of AZ-1 expression were established from Y-1 adrenocortical cells that originally express Cyp11b-1 but little AZ-1 [1].
  • A cDNA encoding a secretory protein hitherto unknown was cloned from mouse adrenocortical cells by subtractive hybridization between the cells without and with expressing steroid 11beta-hydroxylase (Cyp11b-1), a marker for the functional differentiation of cells in the zonae fasciculata reticularis (zFR) [1].
  • The mRNA and its encoded protein were detected in the outer adrenocortical zones that do not express Cyp11b-1, i.e. the zona glomerulosa and the undifferentiated cell zone, while being undetectable in zFR that express Cyp11b-1 [1].
  • The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells [2].
  • We have studied the mechanisms that regulate the expression of the mouse gene encoding steroid 11 beta-hydroxylase (11 beta-OHase), a steroidogenic cytochrome P450 enzyme that is expressed only in the adrenal cortex [3].

Biological context of Cyp11b1


Anatomical context of Cyp11b1

  • Notably, these cell lines displayed distinct expression patterns of the steroid 11 beta-hydroxylase P45011 beta gene responsible for the zone-specific synthesis of corticosterone [6].

Other interactions of Cyp11b1

  • They express the adrenal markers Cyp11b1 and Cyp21 and respond to ACTH [7].
  • Analyses of the clonal lines revealed that Cyp11b-1 is detected in the clonal lines maintaining little AZ-1 expression and becomes undetectable in those expressing AZ-1 [1].


  1. An inverse correlation between expression of a preprocathepsin B-related protein with cysteine-rich sequences and steroid 11beta -hydroxylase in adrenocortical cells. Mukai, K., Mitani, F., Nagasawa, H., Suzuki, R., Suzuki, T., Suematsu, M., Ishimura, Y. J. Biol. Chem. (2003) [Pubmed]
  2. The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells. Wong, M., Rice, D.A., Parker, K.L., Schimmer, B.P. J. Biol. Chem. (1989) [Pubmed]
  3. Identification and characterization of two upstream elements that regulate adrenocortical expression of steroid 11 beta-hydroxylase. Bogerd, A.M., Franklin, A., Rice, D.A., Schimmer, B.P., Parker, K.L. Mol. Endocrinol. (1990) [Pubmed]
  4. Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains. Inglis, G.C., Kenyon, C.J., Szpirer, C., Klinga-Levan, K., Sutcliffe, R.G., Connell, J.M. J. Mol. Endocrinol. (1995) [Pubmed]
  5. Serum-free cultures of murine adrenal cortical cells. Chu, Y., Wu, B.M., McCabe, E.R., Dunn, J.C. J. Pediatr. Surg. (2006) [Pubmed]
  6. Conditionally immortalized adrenocortical cell lines at undifferentiated states exhibit inducible expression of glucocorticoid-synthesizing genes. Mukai, K., Nagasawa, H., Agake-Suzuki, R., Mitani, F., Totani, K., Yanai, N., Obinata, M., Suematsu, M., Ishimura, Y. Eur. J. Biochem. (2002) [Pubmed]
  7. Identification of a novel population of adrenal-like cells in the mammalian testis. Val, P., Jeays-Ward, K., Swain, A. Dev. Biol. (2006) [Pubmed]
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