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Cyp11b3  -  cytochrome P450, family 11, subfamily b,...

Rattus norvegicus

Synonyms: Aldosterone synthase, CYPXIB3, Cyp11b-3, Cytochrome P450 11B3, mitochondrial, Cytochrome P450-Aldo-2, ...
 
 
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Disease relevance of Cyp11b3

  • The aldosterone synthase activities of the mutants were decreased to varying degrees indicating that point mutations at positions 296, 301, 302, and 335 could potentially cause hypoaldosteronism [1].
  • Mouse hepatoma x rat hepatocyte hybrids that segregate rat chromosomes were used to determine the chromosomal location of the rat genes encoding 11 beta-hydroxylase and aldosterone synthase (Cyp11b1 and Cyp11b2 respectively) [2].
  • Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension [3].
  • Hypoxia in vivo inhibits aldosterone synthesis and aldosterone synthase mRNA in rats [4].
  • OBJECTIVE: In consideration of the hypothetical possibility that locally produced aldosterone is likely to take an active part in fibrogenesis of the liver, we undertook the present study to investigate the expression of aldosterone synthase gene CYP11B2 in rat liver and the curative effect of spironolactone on fibrosis of the liver [5].
 

High impact information on Cyp11b3

 

Biological context of Cyp11b3

 

Anatomical context of Cyp11b3

 

Associations of Cyp11b3 with chemical compounds

  • Aldosterone production, activity of aldosterone synthase, and expression of mRNA for CYP11B2 and AT1 receptor were increased in hearts of rats with high sodium intake [17].
  • The adrenocortical enzymes of the steroidogenic late pathway in the rat are aldosterone synthase (P450aldo), which catalyzes the production of aldosterone, and 11 beta-hydroxylase (P45011 beta), which catalyzes the production of corticosterone throughout the cortex [18].
  • Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists [19].
  • I248T, Q43R, and T493M had no effect on steroid production compared to wild-type aldosterone synthase [20].
  • To assess their importance in determining the different functional specificities, we substituted aldosterone synthase-specific (aspartate D147, isoleucine I248, glutamine Q43, and threonine T493) with 11beta-hydroxylase-specific amino acids (glutamate E147, threonine T248, arginine R43, and methionine M493), respectively [20].
 

Other interactions of Cyp11b3

 

Analytical, diagnostic and therapeutic context of Cyp11b3

References

  1. Changed ratios of glucocorticoids/mineralocorticoids caused by point mutations in the putative I-helix regions of CYP11B1 and CYP11B2. Böttner, B., Bernhardt, R. Endocr. Res. (1996) [Pubmed]
  2. Microsatellite polymorphism analysis allows the individual assignment of the rat 11 beta-hydroxylase gene (Cyp11b1) and the rat aldosterone synthase gene (Cyp11b2) to chromosome 7 using rat x mouse somatic cell hybrids and identifies differences between and within various rat strains. Inglis, G.C., Kenyon, C.J., Szpirer, C., Klinga-Levan, K., Sutcliffe, R.G., Connell, J.M. J. Mol. Endocrinol. (1995) [Pubmed]
  3. Molecular variants in the P450c11AS gene as determinants of aldosterone synthase activity in the Dahl rat model of hypertension. Cover, C.M., Wang, J.M., St Lezin, E., Kurtz, T.W., Mellon, S.H. J. Biol. Chem. (1995) [Pubmed]
  4. Hypoxia in vivo inhibits aldosterone synthesis and aldosterone synthase mRNA in rats. Raff, H., Jankowski, B.M., Engeland, W.C., Oaks, M.K. J. Appl. Physiol. (1996) [Pubmed]
  5. CYP11B2 expression in rat liver and the effect of spironolactone on hepatic fibrogenesis. Yang, X., Li, X., Wu, P., Meng, Y., Li, S., Lai, W. Horm. Res. (2000) [Pubmed]
  6. Genetics of hypertension. Munroe, P.B., Caulfield, M.J. Curr. Opin. Genet. Dev. (2000) [Pubmed]
  7. Role of tissue renin in the regulation of aldosterone biosynthesis in the adrenal cortex of nephrectomized rats. Volpe, M., Gigante, B., Enea, I., Porcellini, A., Russo, R., Lee, M.A., Magri, P., Condorelli, G., Savoia, C., Lindpaintner, K., Rubattu, S. Circ. Res. (1997) [Pubmed]
  8. Myocardial production of aldosterone and corticosterone in the rat. Physiological regulation. Silvestre, J.S., Robert, V., Heymes, C., Aupetit-Faisant, B., Mouas, C., Moalic, J.M., Swynghedauw, B., Delcayre, C. J. Biol. Chem. (1998) [Pubmed]
  9. P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally, and hormonally regulated fashion in the rodent adrenal and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities. Mellon, S.H., Bair, S.R., Monis, H. J. Biol. Chem. (1995) [Pubmed]
  10. Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P-450 in rat adrenal cortex. Imai, M., Shimada, H., Okada, Y., Matsushima-Hibiya, Y., Ogishima, T., Ishimura, Y. FEBS Lett. (1990) [Pubmed]
  11. Molecular biology of rat steroid 11 beta-hydroxylase [P450(11 beta)] and aldosterone synthase [P450(11 beta, aldo)]. Okamoto, M., Nonaka, Y. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]
  12. Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Ye, P., Kenyon, C.J., MacKenzie, S.M., Seckl, J.R., Fraser, R., Connell, J.M., Davies, E. Endocrinology (2003) [Pubmed]
  13. Isolation of aldosterone synthase cytochrome P-450 from zona glomerulosa mitochondria of rat adrenal cortex. Ogishima, T., Mitani, F., Ishimura, Y. J. Biol. Chem. (1989) [Pubmed]
  14. Expression of 11beta-hydroxylase and aldosterone synthase genes in the rat brain. MacKenzie, S.M., Clark, C.J., Fraser, R., Gómez-Sánchez, C.E., Connell, J.M., Davies, E. J. Mol. Endocrinol. (2000) [Pubmed]
  15. Development of adrenal zonation in fetal rats defined by expression of aldosterone synthase and 11beta-hydroxylase. Wotus, C., Levay-Young, B.K., Rogers, L.M., Gomez-Sanchez, C.E., Engeland, W.C. Endocrinology (1998) [Pubmed]
  16. Aldosterone biosynthesis in the rat brain. Gomez-Sanchez, C.E., Zhou, M.Y., Cozza, E.N., Morita, H., Foecking, M.F., Gomez-Sanchez, E.P. Endocrinology (1997) [Pubmed]
  17. Sodium-induced cardiac aldosterone synthesis causes cardiac hypertrophy. Takeda, Y., Yoneda, T., Demura, M., Miyamori, I., Mabuchi, H. Endocrinology (2000) [Pubmed]
  18. Differentiation of the expression of aldosterone synthase and 11 beta-hydroxylase mRNA in the rat adrenal cortex by reverse transcriptase-polymerase chain reaction. Oaks, M.K., Raff, H. J. Steroid Biochem. Mol. Biol. (1995) [Pubmed]
  19. Regulation of aldosterone synthase cytochrome P450 (CYP11B2) and 11 beta-hydroxylase cytochrome P450 (CYP11B1) expression in rat adrenal zona glomerulosa cells by low sodium diet and angiotensin II receptor antagonists. Kakiki, M., Morohashi, K., Nomura, M., Omura, T., Horie, T. Biol. Pharm. Bull. (1997) [Pubmed]
  20. Amino acid residue 147 of human aldosterone synthase and 11beta-hydroxylase plays a key role in 11beta-hydroxylation. Fisher, A., Fraser, R., Mc Connell, J., Davies, E. J. Clin. Endocrinol. Metab. (2000) [Pubmed]
  21. Glomerulosa function and aldosterone synthesis in the rat. Vinson, G.P. Mol. Cell. Endocrinol. (2004) [Pubmed]
  22. Inhibition of aldosterone production by testosterone in male rats. Kau, M.M., Lo, M.J., Wang, S.W., Tsai, S.C., Chen, J.J., Chiao, Y.C., Yeh, J.Y., Lin, H., Shum, A.Y., Fang, V.S., Ho, L.T., Wang, P.S. Metab. Clin. Exp. (1999) [Pubmed]
  23. An aldosterone-related system in the ventrolateral medulla oblongata of spontaneously hypertensive and Wistar-Kyoto rats. Kumar, N.N., Goodchild, A.K., Li, Q., Pilowsky, P.M. Clin. Exp. Pharmacol. Physiol. (2006) [Pubmed]
  24. Effects of high sodium intake on cardiovascular aldosterone synthesis in stroke-prone spontaneously hypertensive rats. Takeda, Y., Yoneda, T., Demura, M., Furukawa, K., Miyamori, I., Mabuchi, H. J. Hypertens. (2001) [Pubmed]
  25. Changes of AT(2) receptor levels in the rat adrenal cortex and medulla induced by bilateral nephrectomy and its modulation by circulating ANG II. Peters, B., Clausmeyer, S., Teubner, P., Obermüller, N., Kränzlin, B., Gretz, N., Inagami, T., Peters, J. J. Histochem. Cytochem. (2001) [Pubmed]
  26. Age-related impairment of aldosterone secretion in zona glomerulosa cells of ovariectomized rats. Kau, M.M., Chen, J.J., Wang, S.W., Cho, W.L., Wang, P.S. J. Investig. Med. (1999) [Pubmed]
  27. Corticosteroid production by fetal rat hippocampal neurons. MacKenzie, S.M., Clark, C.J., Ingram, M.C., Lai, M., Seckl, J., Gomez-Sanchez, C.E., Fraser, R., Connell, J.M., Davies, E. Endocr. Res. (2000) [Pubmed]
 
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