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Gene Review

Afr2  -  alpha fetoprotein regulation 2, inducibility

Mus musculus

Synonyms: Afr-2, Rif
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Disease relevance of Afr2

  • Exposure of Rif 7 to heat stress for 5 h in vitro resulted in a 2-log decrease in its 50% lethal dose (P < 0.02) [1].

High impact information on Afr2


Chemical compound and disease context of Afr2

  • Increases in both virulence and envelope protein levels were reversed when heat-treated cells were subsequently grown at 37 degrees C. Inhibition of protein synthesis by actinomycin D during heat stress blocked the increase in virulence of Rif 7 [1].

Biological context of Afr2


Anatomical context of Afr2

  • Here we show that primary hepatocytes isolated from C3H/HeJ and C57BL/6J mice exhibit differential expression of the endogenous AFP gene, which was attributed to the Afr2 gene locus and indicative of a cell-autonomous mechanism [8].

Associations of Afr2 with chemical compounds


Regulatory relationships of Afr2


Other interactions of Afr2


  1. Heat stress alters the virulence of a rifampin-resistant mutant of Francisella tularensis LVS. Bhatnagar, N.B., Elkins, K.L., Fortier, A.H. Infect. Immun. (1995) [Pubmed]
  2. Raf, a trans-acting locus, regulates the alpha-fetoprotein gene in a cell-autonomous manner. Vogt, T.F., Solter, D., Tilghman, S.M. Science (1987) [Pubmed]
  3. alpha-Fetoprotein gene sequences mediating Afr2 regulation during liver regeneration. Jin, D.K., Vacher, J., Feuerman, M.H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  4. Locus unlinked to alpha-fetoprotein under the control of the murine raf and Rif genes. Pachnis, V., Belayew, A., Tilghman, S.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  5. Mouse alpha-fetoprotein gene 5' regulatory elements are required for postnatal regulation by raf and Rif. Spear, B.T. Mol. Cell. Biol. (1994) [Pubmed]
  6. Sequence requirements for Afr-2 regulation of alpha-fetoprotein gene expression during liver regeneration. Jin, D.K., Feuerman, M.H. Somat. Cell Mol. Genet. (1996) [Pubmed]
  7. Genetic analysis of L-ethionine-mediated induction of alpha-fetoprotein in mice. Mifflin, R.C., Moller, P.C., Papaconstantinou, J. Somat. Cell Mol. Genet. (1988) [Pubmed]
  8. Afr2 regulation occurs cell-autonomously in vitro but is not conferred on episomal DNA in transient assays. Park, J.K., Feuerman, M.H. DNA Cell Biol. (2005) [Pubmed]
  9. AFP gene expression after acute diethylnitrosamine intoxication is not Afr2 regulated. Jin, D.K., Anderson, E.C., Gilbert, E., Feuerman, M.H. Cancer Lett. (2005) [Pubmed]
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