Psychiatry related information on ABCB8

• The MABC Test examines children's motor skills in the areas of manual dexterity, ball skills and balance [1].

High impact information on ABCB8

• The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis [2].
• MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis [3].
• M-ABC1 is localized to membranes of the mitochondria and its transcript is expressed in all tissues [4].
• We undertook experiments presented here to target two related mitochondrial membrane proteins, mitochondrial ATP-binding cassette-1 and -2 protein (mABC1 and mABC2, respectively) to the cell surface for functional studies [5].
• ABCB8 and ABCB10 are targeted to the inner mitochondrial membrane [6].

Biological context of ABCB8

• MABC was only significantly related to gestation [7].

Anatomical context of ABCB8

• The N-terminal region of the M-ABC1 protein was shown to function independently as a mitochondrial signal sequence by its ability to target the green fluorescent protein to the mitochondria [4].
• Strong expression of rat abcb8 was found in heart, brain and testis when compared with liver, lung and spleen [8].
• In the testis, rat abcb8 was expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes) [8].

Analytical, diagnostic and therapeutic context of ABCB8

• Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis [8].

References