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Gene Review

ABCB8  -  ATP-binding cassette, sub-family B...

Homo sapiens

Synonyms: ATP-binding cassette sub-family B member 8, mitochondrial, EST328128, M-ABC1, MABC1, Mitochondrial ATP-binding cassette 1
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Psychiatry related information on ABCB8

  • The MABC Test examines children's motor skills in the areas of manual dexterity, ball skills and balance [1].

High impact information on ABCB8


Biological context of ABCB8


Anatomical context of ABCB8

  • The N-terminal region of the M-ABC1 protein was shown to function independently as a mitochondrial signal sequence by its ability to target the green fluorescent protein to the mitochondria [4].
  • Strong expression of rat abcb8 was found in heart, brain and testis when compared with liver, lung and spleen [8].
  • In the testis, rat abcb8 was expressed both in the somatic Sertoli cells and peritubular cells and in the germline (spermatogonia and pachytene spermatocytes) [8].

Analytical, diagnostic and therapeutic context of ABCB8


  1. Gender differences in the attainment of motor skills on the Movement Assessment Battery for Children. Junaid, K.A., Fellowes, S. Physical & occupational therapy in pediatrics. (2006) [Pubmed]
  2. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Pondarré, C., Antiochos, B.B., Campagna, D.R., Clarke, S.L., Greer, E.L., Deck, K.M., McDonald, A., Han, A.P., Medlock, A., Kutok, J.L., Anderson, S.A., Eisenstein, R.S., Fleming, M.D. Hum. Mol. Genet. (2006) [Pubmed]
  3. MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. Mitsuhashi, N., Miki, T., Senbongi, H., Yokoi, N., Yano, H., Miyazaki, M., Nakajima, N., Iwanaga, T., Yokoyama, Y., Shibata, T., Seino, S. J. Biol. Chem. (2000) [Pubmed]
  4. Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein. Hogue, D.L., Liu, L., Ling, V. J. Mol. Biol. (1999) [Pubmed]
  5. Targeting of the mitochondrial membrane proteins to the cell surface for functional studies. Ardehali, H., Xue, T., Dong, P., Machamer, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  6. Intracellular peptide transporters in human - compartmentalization of the "peptidome". Herget, M., Tampé, R. Pflugers Arch. (2007) [Pubmed]
  7. Perinatal and postnatal factors in very preterm infants and subsequent cognitive and motor abilities. Cooke, R.W. Archives of disease in childhood. Fetal and neonatal edition. (2005) [Pubmed]
  8. Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis. Melaine, N., Satie, A.P., Lassurguère, J., Desmots, S., Jégou, B., Samson, M. Int. J. Androl. (2006) [Pubmed]
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