The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Motor Skills

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Motor Skills


Psychiatry related information on Motor Skills


High impact information on Motor Skills

  • OBJECTIVE: To critically review outcomes in early childhood after prenatal cocaine exposure in 5 domains: physical growth; cognition; language skills; motor skills; and behavior, attention, affect, and neurophysiology [11].
  • In a test for coordinated motor skill, however, homozygous Kv3.1-/- mice perform significantly worse than their heterozygous Kv3.1+/- or wild-type littermates [12].
  • Moreover, fluoxetine significantly improved motor skills of the affected side [13].
  • Motor skills tests show that Kv1.1 null mice display a compromised ability to maintain balance on a thin stationary rod [14].
  • Application of the PAS protocols after motor training did not prevent the consolidation of motor skills evident as performance gains at later retesting [15].

Chemical compound and disease context of Motor Skills

  • Seven of eight animals exhibited motor skill impairment which was associated with elevated quinolinic acid in cerebrospinal fluid (CSF) [16].
  • The development of new anxiolytics such as buspirone, which seem to exert less effect on cognitive and motor skills and lack addiction potential (and thus withdrawal problems), presents the clinician with a treatment alternative [17].
  • The authors discuss the extent to which the clinician is responsible for warning patients that benzodiazepine therapy may result in addiction, withdrawal problems, and/or impaired cognitive and motor skills [17].
  • Four groups of six male social drinkers learned a motor skill task and then drank the same dose of ethanol (0.62 g/kg) during each of five drinking sessions [18].
  • These observations suggest that a dissociation of the activity of these two neuropeptide systems may underlie the improvement in motor skill that accompanies dopamine replacement therapy and that this dissociation may be instrumental in the long-term complications associated with L-DOPA therapy [19].

Biological context of Motor Skills


Anatomical context of Motor Skills

  • Nicotine stimulates dendritic arborization in motor cortex and improves concurrent motor skill but impairs subsequent motor learning [24].
  • It is proposed that formation of long-term memories (consolidated receptor mosaics) in the plasma membranes of the striosomal GABA neurons may play a major role in the motivational learning of motor skills of relevance for survival [25].
  • A previous study had shown SCLC patients to have deficits in memory, frontal lobe executive functioning, and motor skills before they received prophylactic cranial irradiation (PCI) [26].
  • Previously, our laboratory demonstrated increased FMRP immunoreactivity in visual cortex of rats exposed to complex environments (EC) and in motor cortex of rats trained on motor-skill tasks compared with animals reared individually in standard laboratory housing (IC) [27].
  • In this paper the motor skill considered is that of paraplegics using their upper limbs whilst standing-up with FES [28].

Gene context of Motor Skills

  • The Rora(-/-) cerebellum is qualitatively a phenocopy of the Rora(sg/sg) one, but the two strains differ slightly in their motor skills [29].
  • The HD mice show abbreviated lifespans (4-6 months), hypoactivity, and mild impairment of motor skills [30].
  • We examined the time course of BDNF and TrkB expression after 1, 3, 5, 7 or 14 days in one of three conditions: (1) an "acrobatic" motor skill learning condition (AC), (2) a motor activity condition (moderately paced running on a flat track; MC) and (3) an inactive social-only control (SC) that served as a baseline group [31].
  • In addition, both Nas1-/- and Nas1+/+ mice displayed similar escape latencies in the acquisition phase of the Morris water maze test, suggesting that learning, motivation, vision and motor skills required for the task may not be affected in Nas1-/- mice [32].
  • Attention and impulse control were consistently found to be important predictors of both fine and gross motor skills in children with ADHD [33].

Analytical, diagnostic and therapeutic context of Motor Skills

  • The results showed that the DAT, AMN, and intact control groups all significantly improved their time on target over six test blocks whereas the HD group was severely impaired in the acquisition of this motor skill [34].
  • In this study we tested the effect of two different technical variants of endothelin-1 application on infarct volume and motor skills (1) application via pre-implanted guiding cannula in awake animals and (2) via direct injection under halothane anaesthesia [35].
  • Consistent with this view, a single oral dose of the selective norepinephrine reuptake inhibitor reboxetine was found to enhance motor skill acquisition (rapid elbow flexion) and corticomotor excitability tested with transcranial magnetic stimulation in the absence of effects on basal motor performance [36].


  1. The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine-depleted rats and MPTP-treated monkeys. Klockgether, T., Turski, L., Honoré, T., Zhang, Z.M., Gash, D.M., Kurlan, R., Greenamyre, J.T. Ann. Neurol. (1991) [Pubmed]
  2. Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis. Glass, W.G., Hickey, M.J., Hardison, J.L., Liu, M.T., Manning, J.E., Lane, T.E. J. Immunol. (2004) [Pubmed]
  3. l-Carnitine. A preliminary review of its pharmacokinetics, and its therapeutic use in ischaemic cardiac disease and primary and secondary carnitine deficiencies in relationship to its role in fatty acid metabolism. Goa, K.L., Brogden, R.N. Drugs (1987) [Pubmed]
  4. Neuropsychological function in obstructive sleep apnea syndrome (OSAS) compared to chronic obstructive pulmonary disease (COPD). Roehrs, T., Merrion, M., Pedrosi, B., Stepanski, E., Zorick, F., Roth, T. Sleep. (1995) [Pubmed]
  5. Ethanol-induced suppression of cell-mediated immunity in the mouse. Jayasinghe, R., Gianutsos, G., Hubbard, A.K. Alcohol. Clin. Exp. Res. (1992) [Pubmed]
  6. A survey of cognitive functioning at difference glucose levels in diabetic persons. Holmes, C.S., Hayford, J.T., Gonzalez, J.L., Weydert, J.A. Diabetes Care (1983) [Pubmed]
  7. Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. Stordy, B.J. Am. J. Clin. Nutr. (2000) [Pubmed]
  8. Postnatal caffeine exposure: effects on motor skills and locomotor activity during ontogenesis. Tchekalarova, J., Kubova, H., Mares, P. Behav. Brain Res. (2005) [Pubmed]
  9. School attainments in children with congenital hypothyroidism detected by neonatal screening and treated early in life. Bargagna, S., Dinetti, D., Pinchera, A., Marcheschi, M., Montanelli, L., Presciuttini, S., Chiovato, L. Eur. J. Endocrinol. (1999) [Pubmed]
  10. Late neurodevelopmental outcome after repair of total anomalous pulmonary venous connection. Kirshbom, P.M., Flynn, T.B., Clancy, R.R., Ittenbach, R.F., Hartman, D.M., Paridon, S.M., Wernovsky, G., Spray, T.L., Gaynor, J.W. J. Thorac. Cardiovasc. Surg. (2005) [Pubmed]
  11. Growth, development, and behavior in early childhood following prenatal cocaine exposure: a systematic review. Frank, D.A., Augustyn, M., Knight, W.G., Pell, T., Zuckerman, B. JAMA (2001) [Pubmed]
  12. Pleiotropic effects of a disrupted K+ channel gene: reduced body weight, impaired motor skill and muscle contraction, but no seizures. Ho, C.S., Grange, R.W., Joho, R.H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  13. Fluoxetine modulates motor performance and cerebral activation of patients recovering from stroke. Pariente, J., Loubinoux, I., Carel, C., Albucher, J.F., Leger, A., Manelfe, C., Rascol, O., Chollet, F. Ann. Neurol. (2001) [Pubmed]
  14. Specific alteration of spontaneous GABAergic inhibition in cerebellar purkinje cells in mice lacking the potassium channel Kv1. 1. Zhang, C.L., Messing, A., Chiu, S.Y. J. Neurosci. (1999) [Pubmed]
  15. Temporary occlusion of associative motor cortical plasticity by prior dynamic motor training. Stefan, K., Wycislo, M., Gentner, R., Schramm, A., Naumann, M., Reiners, K., Classen, J. Cereb. Cortex (2006) [Pubmed]
  16. Cytopathologic and neurochemical correlates of progression to motor/cognitive impairment in SIV-infected rhesus monkeys. Rausch, D.M., Heyes, M.P., Murray, E.A., Lendvay, J., Sharer, L.R., Ward, J.M., Rehm, S., Nohr, D., Weihe, E., Eiden, L.E. J. Neuropathol. Exp. Neurol. (1994) [Pubmed]
  17. Consent and liability: special problems with anxiolytics. Mills, M.J., Eth, S. The Journal of clinical psychiatry. (1987) [Pubmed]
  18. Mental rehearsal and classical conditioning contribute to ethanol tolerance in humans. Annear, W.C., Vogel-Sprott, M. Psychopharmacology (Berl.) (1985) [Pubmed]
  19. Effects of L-DOPA on preproenkephalin and preprotachykinin gene expression in the MPTP-treated monkey striatum. Herrero, M.T., Augood, S.J., Hirsch, E.C., Javoy-Agid, F., Luquin, M.R., Agid, Y., Obeso, J.A., Emson, P.C. Neuroscience (1995) [Pubmed]
  20. A gestational monkey model: effects of phenytoin versus seizures on neonatal outcome. Phillips, N.K., Lockard, J.S. Epilepsia (1985) [Pubmed]
  21. Hypothyroxinemia of prematurity and infant neurodevelopment: a pilot study. Ishaik, G., Asztalos, E., Perlman, K., Newton, S., Frisk, V., Rovet, J. Journal of developmental and behavioral pediatrics : JDBP. (2000) [Pubmed]
  22. Familial factors and hearing impairment modulate the neuromotor phenotype in Turner syndrome. Haverkamp, F., Keuker, T., Woelfle, J., Kaiser, G., Zerres, K., Rietz, C., Ruenger, M. Eur. J. Pediatr. (2003) [Pubmed]
  23. Visual impairment in very low birthweight children. Powls, A., Botting, N., Cooke, R.W., Stephenson, G., Marlow, N. Archives of disease in childhood. Fetal and neonatal edition. (1997) [Pubmed]
  24. Nicotine stimulates dendritic arborization in motor cortex and improves concurrent motor skill but impairs subsequent motor learning. Gonzalez, C.L., Gharbawie, O.A., Whishaw, I.Q., Kolb, B. Synapse (2005) [Pubmed]
  25. Possible role of intramembrane receptor-receptor interactions in memory and learning via formation of long-lived heteromeric complexes: focus on motor learning in the basal ganglia. Agnati, L.F., Franzen, O., Ferré, S., Leo, G., Franco, R., Fuxe, K. J. Neural Transm. Suppl. (2003) [Pubmed]
  26. Cognitive deficits in patients with small cell lung cancer before and after chemotherapy. Meyers, C.A., Byrne, K.S., Komaki, R. Lung Cancer (1995) [Pubmed]
  27. Fragile X mental retardation protein levels increase following complex environment exposure in rat brain regions undergoing active synaptogenesis. Irwin, S.A., Christmon, C.A., Grossman, A.W., Galvez, R., Kim, S.H., DeGrush, B.J., Weiler, I.J., Greenough, W.T. Neurobiology of learning and memory. (2005) [Pubmed]
  28. Control of FES in paraplegia: modeling voluntary arm forces. Andrews, B.J., Davoodi, R., Kamnik, R., Bajd, T. Bio-medical materials and engineering. (1998) [Pubmed]
  29. A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-/-). Doulazmi, M., Frédéric, F., Capone, F., Becker-André, M., Delhaye-Bouchaud, N., Mariani, J. Brain Res. Dev. Brain Res. (2001) [Pubmed]
  30. Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA. Schilling, G., Jinnah, H.A., Gonzales, V., Coonfield, M.L., Kim, Y., Wood, J.D., Price, D.L., Li, X.J., Jenkins, N., Copeland, N., Moran, T., Ross, C.A., Borchelt, D.R. Neurobiol. Dis. (2001) [Pubmed]
  31. Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise. Klintsova, A.Y., Dickson, E., Yoshida, R., Greenough, W.T. Brain Res. (2004) [Pubmed]
  32. Impaired memory and olfactory performance in NaSi-1 sulphate transporter deficient mice. Dawson, P.A., Steane, S.E., Markovich, D. Behav. Brain Res. (2005) [Pubmed]
  33. Relationship between motor proficiency, attention, impulse, and activity in children with ADHD. Tseng, M.H., Henderson, A., Chow, S.M., Yao, G. Developmental medicine and child neurology. (2004) [Pubmed]
  34. Impaired learning of a motor skill in patients with Huntington's disease. Heindel, W.C., Butters, N., Salmon, D.P. Behav. Neurosci. (1988) [Pubmed]
  35. Detection of chronic sensorimotor impairments in the ladder rung walking task in rats with endothelin-1-induced mild focal ischemia. Riek-Burchardt, M., Henrich-Noack, P., Metz, G.A., Reymann, K.G. J. Neurosci. Methods (2004) [Pubmed]
  36. Improved motor skill acquisition after selective stimulation of central norepinephrine. Plewnia, C., Hoppe, J., Cohen, L.G., Gerloff, C. Neurology (2004) [Pubmed]
WikiGenes - Universities