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Gene Review

SCRG1  -  stimulator of chondrogenesis 1

Homo sapiens

Synonyms: SCRG-1, ScRG-1, Scrapie-responsive gene 1 protein, Scrapie-responsive protein 1, UNQ390/PRO725
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Disease relevance of SCRG1


High impact information on SCRG1

  • ScRG-1 mRNA was found to be preferentially expressed in glial cells and to code for a short protein of 47 amino acids with a strong hydrophobic N-terminal region [2].
  • Examination of the distribution of human ScRG-1 mRNA in adult and fetal tissues revealed that the gene was expressed primarily in the central nervous system as a 0.7-kilobase message and was under strict developmental control [3].
  • Three genes in the 4q33-35.1 haplotype region were also differentially expressed in schizophrenia in postmortem dorsolateral prefrontal cortex: AGA, HMGB2, and SCRG1 [4].
  • Comparison of the rat, mouse, and human SCRG1 proteins identified a box of 35 identical contiguous amino acids and a characteristic cysteine distribution pattern defining a new protein signature [5].
  • A predominantly articular cartilage-associated gene, SCRG1, is induced by glucocorticoid and stimulates chondrogenesis in vitro [6].
  • Aomatsu et al. identified a novel SCRG1/BST1 ligand-receptor combination that maintains human mesenchymal stem cells expressions of stem cell markers Oct-4 and CD271/LNGFR, as well as self-renewal, migration, and osteogenic differentiation potentials during ex vivo expansion [7].

Biological context of SCRG1

  • Forced expression of SCRG1 in hMSCs suppressed their proliferation, and stimulated chondrogenesis in C3H10T1/2 cells, confirmed by reduced collagen type I and elevated collagen type IIB expression [6].
  • The cultures were analyzed by reverse transcription-polymerase chain reaction for the expression of SCRG1 and cartilage marker genes, and by histological staining for cartilage phenotype [6].
  • CONCLUSION: These results suggest that SCRG1 is involved in cell growth suppression and differentiation during DEX-dependent chondrogenesis [6].

Other interactions of SCRG1


Analytical, diagnostic and therapeutic context of SCRG1


  1. SCRG1, a Potential Marker of Autophagy in Transmissible Spongiform Encephalopathies. Dron, M., Bailly, Y., Beringue, V., Haeberlé, A.M., Griffond, B., Risold, P.Y., Tovey, M.G., Laude, H., Dandoy-Dron, F. Autophagy. (2006) [Pubmed]
  2. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron, F., Guillo, F., Benboudjema, L., Deslys, J.P., Lasmézas, C., Dormont, D., Tovey, M.G., Dron, M. J. Biol. Chem. (1998) [Pubmed]
  3. Characterization of the human analogue of a Scrapie-responsive gene. Dron, M., Dandoy-Dron, F., Guillo, F., Benboudjema, L., Hauw, J.J., Lebon, P., Dormont, D., Tovey, M.G. J. Biol. Chem. (1998) [Pubmed]
  4. Genome scans and gene expression microarrays converge to identify gene regulatory loci relevant in schizophrenia. Vawter, M.P., Atz, M.E., Rollins, B.L., Cooper-Casey, K.M., Shao, L., Byerley, W.F. Hum. Genet. (2006) [Pubmed]
  5. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. Dron, M., Tartare, X., Guillo, F., Haik, S., Barbin, G., Maury, C., Tovey, M., Dandoy-Dron, F. Genomics (2000) [Pubmed]
  6. A predominantly articular cartilage-associated gene, SCRG1, is induced by glucocorticoid and stimulates chondrogenesis in vitro. Ochi, K., Derfoul, A., Tuan, R.S. Osteoarthr. Cartil. (2006) [Pubmed]
  7. Novel SCRG1/BST1 axis regulates self-renewal, migration, and osteogenic differentiation potential in mesenchymal stem cells. Aomatsu, E., Takahashi, N., Sawada, S., Okubo, N., Hasegawa, T., Taira, M., Miura, H., Ishisaki, A., Chosa, N. Sci. Rep. (2014) [Pubmed]
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