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Gene Review

Scrg1  -  scrapie responsive gene 1

Mus musculus

Synonyms: AW124307, ScRG-1, Scrapie-responsive gene 1 protein, Scrapie-responsive protein 1
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Disease relevance of Scrg1


Psychiatry related information on Scrg1


High impact information on Scrg1


Biological context of Scrg1

  • We have sequenced 20 kb of DNA at the mouse Scrg1 locus and found that the longer transcript is the prolongation of the 0.7-kb mRNA to a polyadenylation site located about 2 kb further downstream [1].

Anatomical context of Scrg1


Associations of Scrg1 with chemical compounds

  • (iii) Scrg1 is enriched in fractions of sucrose density gradient where synaptotagmin V, a dense-core vesicle-associated protein, is also enriched [6].

Analytical, diagnostic and therapeutic context of Scrg1

  • Northern blot analysis showed that Scrg1 is under strict developmental control in mouse embryo and is expressed by cells of neuronal origin in vitro [1].


  1. Mouse scrapie responsive gene 1 (Scrg1): genomic organization, physical linkage to sap30, genetic mapping on chromosome 8, and expression in neuronal primary cell cultures. Dron, M., Tartare, X., Guillo, F., Haik, S., Barbin, G., Maury, C., Tovey, M., Dandoy-Dron, F. Genomics (2000) [Pubmed]
  2. Scrg1 is induced in TSE and brain injuries, and associated with autophagy. Dron, M., Bailly, Y., Beringue, V., Haeberlé, A.M., Griffond, B., Risold, P.Y., Tovey, M.G., Laude, H., Dandoy-Dron, F. Eur. J. Neurosci. (2005) [Pubmed]
  3. SCRG1, a Potential Marker of Autophagy in Transmissible Spongiform Encephalopathies. Dron, M., Bailly, Y., Beringue, V., Haeberlé, A.M., Griffond, B., Risold, P.Y., Tovey, M.G., Laude, H., Dandoy-Dron, F. Autophagy. (2006) [Pubmed]
  4. Enhanced levels of scrapie responsive gene mRNA in BSE-infected mouse brain. Dandoy-Dron, F., Benboudjema, L., Guillo, F., Jaegly, A., Jasmin, C., Dormont, D., Tovey, M.G., Dron, M. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  5. Gene expression in scrapie. Cloning of a new scrapie-responsive gene and the identification of increased levels of seven other mRNA transcripts. Dandoy-Dron, F., Guillo, F., Benboudjema, L., Deslys, J.P., Lasmézas, C., Dormont, D., Tovey, M.G., Dron, M. J. Biol. Chem. (1998) [Pubmed]
  6. Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells. Dandoy-Dron, F., Griffond, B., Mishal, Z., Tovey, M.G., Dron, M. Eur. J. Neurosci. (2003) [Pubmed]
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