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Gene Review

traR  -  transcriptional activator

Agrobacterium fabrum str. C58

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Disease relevance of traR

  • Octopine stimulates expression of the traR gene, whose product directly activates other tra genes in the presence of an acylated homoserine lactone called Agrobacterium autoinducer (AAI) [1].

High impact information on traR


Chemical compound and disease context of traR


Biological context of traR


Associations of traR with chemical compounds


Other interactions of traR


  1. Conserved cis-acting promoter elements are required for density-dependent transcription of Agrobacterium tumefaciens conjugal transfer genes. Fuqua, C., Winans, S.C. J. Bacteriol. (1996) [Pubmed]
  2. The A. tumefaciens transcriptional activator OccR causes a bend at a target promoter, which is partially relaxed by a plant tumor metabolite. Wang, L., Helmann, J.D., Winans, S.C. Cell (1992) [Pubmed]
  3. Conjugation factor of Agrobacterium tumefaciens regulates Ti plasmid transfer by autoinduction. Piper, K.R., Beck von Bodman, S., Farrand, S.K. Nature (1993) [Pubmed]
  4. Mutational analysis of TraR. Correlating function with molecular structure of a quorum-sensing transcriptional activator. Luo, Z.Q., Smyth, A.J., Gao, P., Qin, Y., Farrand, S.K. J. Biol. Chem. (2003) [Pubmed]
  5. The antiactivator TraM interferes with the autoinducer-dependent binding of TraR to DNA by interacting with the C-terminal region of the quorum-sensing activator. Luo, Z.Q., Qin, Y., Farrand, S.K. J. Biol. Chem. (2000) [Pubmed]
  6. Dimerization properties of TraM, the antiactivator that modulates TraR-mediated quorum-dependent expression of the Ti plasmid tra genes. Qin, Y., Smyth, A.J., Su, S., Farrand, S.K. Mol. Microbiol. (2004) [Pubmed]
  7. In situ activation of the quorum-sensing transcription factor TraR by cognate and noncognate acyl-homoserine lactone ligands: kinetics and consequences. Luo, Z.Q., Su, S., Farrand, S.K. J. Bacteriol. (2003) [Pubmed]
  8. Quorum sensing but not autoinduction of Ti plasmid conjugal transfer requires control by the opine regulon and the antiactivator TraM. Piper, K.R., Farrand, S.K. J. Bacteriol. (2000) [Pubmed]
  9. The bacterial 'enigma': cracking the code of cell-cell communication. Salmond, G.P., Bycroft, B.W., Stewart, G.S., Williams, P. Mol. Microbiol. (1995) [Pubmed]
  10. The binding site of the transcriptional activator VirG from Agrobacterium comprises both conserved and specific nonconserved sequences. Roitsch, T., Jin, S., Nester, E.W. FEBS Lett. (1994) [Pubmed]
  11. Characterisation of novel target promoters for the dexamethasone-inducible/tetracycline-repressible regulator TGV using luciferase and isopentenyl transferase as sensitive reporter genes. Böhner, S., Gatz, C. Mol. Gen. Genet. (2001) [Pubmed]
  12. Activity of the Agrobacterium Ti plasmid conjugal transfer regulator TraR is inhibited by the product of the traM gene. Fuqua, C., Burbea, M., Winans, S.C. J. Bacteriol. (1995) [Pubmed]
  13. Modulating quorum sensing by antiactivation: TraM interacts with TraR to inhibit activation of Ti plasmid conjugal transfer genes. Hwang, I., Smyth, A.J., Luo, Z.Q., Farrand, S.K. Mol. Microbiol. (1999) [Pubmed]
  14. An Agrobacterium two-component regulatory system for the detection of chemicals released from plant wounds. Winans, S.C. Mol. Microbiol. (1991) [Pubmed]
  15. A chromosomally encoded two-component sensory transduction system is required for virulence of Agrobacterium tumefaciens. Charles, T.C., Nester, E.W. J. Bacteriol. (1993) [Pubmed]
  16. Analogs of the autoinducer 3-oxooctanoyl-homoserine lactone strongly inhibit activity of the TraR protein of Agrobacterium tumefaciens. Zhu, J., Beaber, J.W., Moré, M.I., Fuqua, C., Eberhard, A., Winans, S.C. J. Bacteriol. (1998) [Pubmed]
  17. A new regulatory element modulates homoserine lactone-mediated autoinduction of Ti plasmid conjugal transfer. Hwang, I., Cook, D.M., Farrand, S.K. J. Bacteriol. (1995) [Pubmed]
  18. Genetic and sequence analysis of the pTiC58 trb locus, encoding a mating-pair formation system related to members of the type IV secretion family. Li, P.L., Everhart, D.M., Farrand, S.K. J. Bacteriol. (1998) [Pubmed]
  19. Controlled expression of the transcriptional activator gene virG in Agrobacterium tumefaciens by using the Escherichia coli lac promoter. Chen, C.Y., Winans, S.C. J. Bacteriol. (1991) [Pubmed]
  20. Quorum-sensing antiactivator TraM forms a dimer that dissociates to inhibit TraR. Chen, G., Malenkos, J.W., Cha, M.R., Fuqua, C., Chen, L. Mol. Microbiol. (2004) [Pubmed]
  21. Conservation of PcaQ, a transcriptional activator of pca genes for catabolism of phenolic compounds, in Agrobacterium tumefaciens and Rhizobium species. Parke, D. J. Bacteriol. (1996) [Pubmed]
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