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Gene Review

Pax3  -  paired box 3

Rattus norvegicus

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Disease relevance of Pax3


High impact information on Pax3

  • In addition, IL6RIL6 leads to a disappearance of Pax-3, a marker of eSC and nonmyelinating Schwann cells (nmSC) [2].
  • Interestingly, expression of BDNF correlated with that of Pax3, a marker of muscle progenitor cells, in several different adult skeletal muscles [3].
  • Pax3 function is required for cardiac neural crest cells to complete their migration to the developing heart [1].
  • In conclusion, Pax3 is underexpressed in the hearts of nitrofen-exposed embryonal rats before the end of gestation [1].
  • Pax3 mRNA expression in the heart was significantly decreased on E15 in nitrofen-treated embryos (32.94+/-17.11 U vs. 55.09+/-11.56 U, p<0.05), and it was still decreased, although not significantly, in the hearts of nitrofen-exposed fetuses recovered on E21 (15.67+/-5.56 U vs. 20.51+/-5.92 U, not significant) [1].

Analytical, diagnostic and therapeutic context of Pax3


  1. Pax3 mRNA is decreased in the hearts of rats with experimental diaphragmatic hernia. Gonzalez-Reyes, S., Fernandez-Dumont, V., Martinez-Calonge, W., Martinez, L., Hernandez, F., Tovar, J. Pediatr. Surg. Int. (2005) [Pubmed]
  2. Stimulation of myelin gene expression in vitro and of sciatic nerve remyelination by interleukin-6 receptor-interleukin-6 chimera. Haggiag, S., Zhang, P.L., Slutzky, G., Shinder, V., Kumar, A., Chebath, J., Revel, M. J. Neurosci. Res. (2001) [Pubmed]
  3. BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation. Mousavi, K., Jasmin, B.J. J. Neurosci. (2006) [Pubmed]
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