Disease relevance of Hernia, Diaphragmatic

• Pulmonary hypertension in lambs with congenital diaphragmatic hernia: vasodilator prostaglandins, isoprenaline, and tolazoline [1].
• BACKGROUND: Nitrofen (2,4-dichloro-4'-nitrodiphenyl ether), a diapheny ether herbicide, is known to induce in rat fetuses a variety of congenital cardiovascular anomalies, together with diaphragmatic hernia and hydronephrosis [2].
• Victorian blue van Gieson staining and Immunostaining with anti-alpha smooth muscle actin (ASMA) were performed on lung tissues obtained during autopsy from 21 patients who had congenital diaphragmatic hernia (CDH) complicated by persistent pulmonary hypertension (PPH) and 10 control patients who died of sudden infant death syndrome (SIDS) [3].
• This analysis concerns three groups of malformations: Congenital diaphragmatic hernia, patent ductus arteriosus, and oesophageal atresia [4].
• Aspirin (ASA), an irreversible cyclooxygenase (COX) inhibitor, induces ventricular septal defect (VSD) and diaphragmatic hernia (DH) in rat fetuses when administered on gestation days (GDs) 9-10, a critical period for cardiovascular (CV) and midline development [5].

High impact information on Hernia, Diaphragmatic

• Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents [6].
• As a result, diaphragmatic hernias were created on day 80, intravenous catheters were placed on day 120, and twice-daily intravenous cortisol injections (n = 8) or saline as the control (n = 5) were administered (days 133-135) [7].
• Intrapericardial diaphragmatic hernia (IDH) is the rarest type of adult diaphragmatic hernia [8].
• Restoring effects of vitamin A on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats [9].
• We hypothesized that the expression of surfactant protein A (SP-A) would be altered in developing lungs from rat fetuses with congenital diaphragmatic hernia (CDH) induced by maternal ingestion of 2,4-dichlorophenyl-p-nitrophenyl ether (Nitrofen) on Day 9 of gestation [10].

Chemical compound and disease context of Hernia, Diaphragmatic

• PURPOSE: To determine the serial radiographic appearance of the lungs of neonates who underwent partial liquid ventilation with perflubron because of congenital diaphragmatic hernia (CDH) or primary pulmonary hypertension [11].
• Antenatal dexamethasone administration increases fetal lung DNA synthesis and RNA and protein content in nitrofen-induced congenital diaphragmatic hernia in rats [12].
• Effect of ABT-627 (A-147627), a potent selective ET(A) receptor antagonist, on the cardiopulmonary profile of newborn lambs with surgically-induced diaphragmatic hernia [13].
• CONCLUSIONS: ITPV significantly improved CO2 removal in newborn lambs with diaphragmatic hernias without increasing airway pressures or changing oxygenation [14].
• DESIGN: The cost-effectiveness analysis is based on outcome and utilization data from two multicentered randomized clinical trials conducted by the Canadian Inhaled Nitric Oxide Study group, one for patients with congenital diaphragmatic hernia (CDH) and one for patients without CDH [15].

Biological context of Hernia, Diaphragmatic

• Endothelin-1 pulmonary vasoconstriction in rats with diaphragmatic hernia [16].
• Recently, low expression of TTF-1 in the nitrofen rat model of congenital diaphragmatic hernia (CDH) was shown and restoration of this downregulation by antenatal glucocorticolds (CS) was reported [17].

Anatomical context of Hernia, Diaphragmatic

• Pathophysiology of congenital diaphragmatic hernia. X: Localization of nitric oxide synthase in the intima of pulmonary artery trunks of lambs with surgically created congenital diaphragmatic hernia [18].
• The present study examines the effects of early exposure to vitamin A on the neural-crest-related cardiovascular, thymic, parathyroid, and thyroid malformations previously reported in the rat model of congenital diaphragmatic hernia (CDH) [19].
• The SIS extracellular matrix scaffold-preliminary results of use in congenital diaphragmatic hernia (CDH) repair [20].
• Gastroesophageal reflux associated with anatomic and functional abnormalities of the esophagus may be encountered following the repair of a congenital diaphragmatic hernia (CDH) [21].

Gene context of Hernia, Diaphragmatic

• Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice [22].
• Pax3 mRNA is decreased in the hearts of rats with experimental diaphragmatic hernia [23].
• Increasing fetal lung distension by tracheal occlusion (TO) accelerated the normal maturational pattern of VEGF-A isoforms and increased VEGF-A protein; decreasing fetal lung distension by congenital diaphragmatic hernia (CDH) retarded the normal developmental pattern and decreased VEGF-A protein [24].
• Furthermore, mice that are homozygous for a deletion in the mouse homolog of WT1 have diaphragmatic hernias [25].
• The authors recently demonstrated depressed levels of catalase, glutathione peroxidase, and superoxide dismutase in congenital diaphragmatic hernia (CDH) lambs compared with controls [26].

Analytical, diagnostic and therapeutic context of Hernia, Diaphragmatic

• Slit3-deficient mice represent a genetic animal model for physiological and pathological studies of congenital diaphragmatic hernia [22].
• VEGF PCR of mRNA isolated from fetal sheep subjected to surgical creation of diaphragmatic hernia both with (DH-TL) and without (DH) tracheal ligation also was analyzed [27].
• Newborn surgical emergencies. Congenital diaphragmatic hernia and extracorporeal membrane oxygenation [28].
• An ad hoc multicenter study group (the Congenital Diaphragmatic Hernia Study Group) has been formed for this purpose [29].
• We investigated the immunohistochemical expression of MMP-9 in the bilateral lungs of newborns with congenital diaphragmatic hernia (CDH) during mechanical ventilation and evaluated the degree of damage based on MMP-9 expression [30].

References