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CARD16  -  caspase recruitment domain family, member 16

Homo sapiens

Synonyms: CARD-only protein 1, COP, COP1, Caspase recruitment domain-containing protein 16, Caspase recruitment domain-only protein 1, ...
 
 
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Disease relevance of COP1

  • BACKGROUND: The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting [1].
 

High impact information on COP1

  • These N-terminal specificity regions (COP1 and COP2) are predicted to be helical and are potential dimerization interfaces [2].
  • Interestingly, both Pseudo-ICE and ICEBERG are mapped to chromosome 11q22 that bears caspases-1, -4- and -5 genes, all involved in cytokine production rather than in apoptosis [3].
  • We demonstrate that Pseudo-ICE and ICEBERG interact physically with caspase-1 and block, in a monocytic cell line, the interferon-gamma and lipopolysaccharide-induced secretion of interleukin-1beta which is a well-known consequence of caspase-1 activation [3].
  • The INCA gene is located on chromosome 11q22 between the genes of COP/Pseudo-ICE and ICEBERG, two other CARD proteins that arose from caspase-1 gene duplications [4].
  • Furthermore, we also show that the COP1 protein bears a bipartite-type NLS and its nuclear import is mediated preferentially by the rice importin alpha1b [5].
 

Anatomical context of COP1

  • Patients with VPA IDRs have deficient erythrocyte glutathione peroxidase activity, low plasma selenium concentrations, low COP1 ratios, and low COP2 ratios compared with age-matched controls [6].
  • Protein factors involved in these processes, such as the photoreceptor, phytochrome B, a key regulatory protein, COP1, and some bZIP transcription factors have been identified and their light-regulated movement between the cytoplasm and the nucleus has been demonstrated [7].
  • The mutant also developed Pchlide-containing plastids in the roots, indicating the suppressing effect of the COP1 locus on development of plastids in the corresponding tissues in dark-grown wild-type plants [8].
 

Associations of COP1 with chemical compounds

 

Other interactions of COP1

  • The distribution of protochlorophyllide (Pchlide) and NADPH-Pchlide oxidoreductase (POR) was characterized in the epicotyls and roots of wild-type pea (Pisum sativum L. cv. Alaska) and lip1, a mutant with light-independent photomorphogenesis caused by a mutation in the COP1 locus [8].
 

Analytical, diagnostic and therapeutic context of COP1

  • Molecular cloning of a novel importin alpha homologue from rice, by which constitutive photomorphogenic 1 (COP1) nuclear localization signal (NLS)-protein is preferentially nuclear imported [5].

References

  1. ARF1 regulates Nef-induced CD4 degradation. Fauré, J., Stalder, R., Borel, C., Sobo, K., Piguet, V., Demaurex, N., Gruenberg, J., Trono, D. Curr. Biol. (2004) [Pubmed]
  2. Two classes of homeodomain proteins specify the multiple a mating types of the mushroom Coprinus cinereus. Kües, U., Asante-Owusu, R.N., Mutasa, E.S., Tymon, A.M., Pardo, E.H., O'Shea, S.F., Göttgens, B., Casselton, L.A. Plant Cell (1994) [Pubmed]
  3. Regulation of IL-1beta generation by Pseudo-ICE and ICEBERG, two dominant negative caspase recruitment domain proteins. Druilhe, A., Srinivasula, S.M., Razmara, M., Ahmad, M., Alnemri, E.S. Cell Death Differ. (2001) [Pubmed]
  4. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. Lamkanfi, M., Denecker, G., Kalai, M., D'hondt, K., Meeus, A., Declercq, W., Saelens, X., Vandenabeele, P. J. Biol. Chem. (2004) [Pubmed]
  5. Molecular cloning of a novel importin alpha homologue from rice, by which constitutive photomorphogenic 1 (COP1) nuclear localization signal (NLS)-protein is preferentially nuclear imported. Jiang, C.J., Shoji, K., Matsuki, R., Baba, A., Inagaki, N., Ban, H., Iwasaki, T., Imamoto, N., Yoneda, Y., Deng, X.W., Yamamoto, N. J. Biol. Chem. (2001) [Pubmed]
  6. Idiosyncratic reactions: new methods of identifying high-risk patients. Glauser, T.A. Epilepsia (2000) [Pubmed]
  7. Protein nucleocytoplasmic transport and its light regulation in plants. Yamamoto, N., Deng, X.W. Genes Cells (1999) [Pubmed]
  8. The distribution of protochlorophyllide and chlorophyll within seedlings of the lip1 mutant of Pea. Seyedi, M., Timko, M.P., Sundqvist, C. Plant Cell Physiol. (2001) [Pubmed]
 
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