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Chemical Compound Review

Felbamyl     (3-aminocarbonyloxy-2-phenyl- propyl)...

Synonyms: Felbatol, Felbamato, felbamate, Felbamatum, Taloxa, ...
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Disease relevance of felbamate


Psychiatry related information on felbamate


High impact information on felbamate


Chemical compound and disease context of felbamate


Biological context of felbamate


Anatomical context of felbamate

  • RESULTS: Felbamate (200 mg/kg IV) administered after the release of carotid clamping did not change brain temperature but reduced neuronal death in CA1 from 332 +/- 60 cells per section of dorsal hippocampus in unmedicated gerbils to 62 +/- 12 cells in felbamate-treated animals (P<.001) [5].
  • Post hoc felbamate (300 mg/kg) reduced the volume of infarction from 67% +/- 7% of neocortex in unmedicated rats to 32% +/- 8%, 51% +/- 12%, 38% +/- 19%, and 53% +/- 10% when given 0, 1, 2, and 4 hours after hypoxic exposure, respectively [12].
  • The most common adverse effects occurring during administration of felbamate are mild to moderate gastrointestinal (nausea, vomiting and anorexia) and central nervous system (headache, somnolence, diplopia, dizziness and insomnia) disturbances [19].
  • We sought to identify the sites at which felbamate exerts its NMDA receptor blocking action using radioligand binding to rat forebrain membranes and whole-cell voltage clamp and single-channel recordings from cultured rat hippocampal neurons [21].
  • Blood-brain barrier penetration of felbamate [22].

Associations of felbamate with other chemical compounds


Gene context of felbamate


Analytical, diagnostic and therapeutic context of felbamate


  1. Aplastic anemia in a patient receiving felbamate for complex partial seizures. Pennell, P.B., Ogaily, M.S., Macdonald, R.L. Neurology (1995) [Pubmed]
  2. Felbamate-associated fatal acute hepatic necrosis. O'Neil, M.G., Perdun, C.S., Wilson, M.B., McGown, S.T., Patel, S. Neurology (1996) [Pubmed]
  3. The NMDA receptor complex: a promising target for novel antiepileptic strategies. Kohl, B.K., Dannhardt, G. Current medicinal chemistry. (2001) [Pubmed]
  4. Protective effects of felbamate against hypoxia in the rat hippocampal slice. Wallis, R.A., Panizzon, K.L., Fairchild, M.D., Wasterlain, C.G. Stroke (1992) [Pubmed]
  5. Felbamate protects CA1 neurons from apoptosis in a gerbil model of global ischemia. Wasterlain, C.G., Adams, L.M., Wichmann, J.K., Sofia, R.D. Stroke (1996) [Pubmed]
  6. Interaction of felbamate with several other antiepileptic drugs against seizures induced by maximal electroshock in mice. Gordon, R., Gels, M., Wichmann, J., Diamantis, W., Sofia, R.D. Epilepsia (1993) [Pubmed]
  7. Effect of lamotrigine combined with felbamate on the horizontal (ambulatory) activity in mice. Luszczki, J.J., Andres, M.M., Swiader, M.J. Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina. (2004) [Pubmed]
  8. Advances in the medical treatment of epilepsy. Bazil, C.W., Pedley, T.A. Annu. Rev. Med. (1998) [Pubmed]
  9. The use of felbamate in the treatment of patients with intractable epilepsy. Benbadis, S. Neurology (2000) [Pubmed]
  10. Felbamate: clinical and molecular aspects of a unique antiepileptic drug. Brown, W.M., Aiken, S.P. Critical reviews in neurobiology. (1998) [Pubmed]
  11. Effects of felbamate on the pharmacokinetics of phenobarbital. Reidenberg, P., Glue, P., Banfield, C.R., Colucci, R.D., Meehan, J.W., Radwanski, E., Mojavarian, P., Lin, C.C., Nezamis, J., Guillaume, M. Clin. Pharmacol. Ther. (1995) [Pubmed]
  12. Posthypoxic treatment with felbamate is neuroprotective in a rat model of hypoxia-ischemia. Wasterlain, C.G., Adams, L.M., Schwartz, P.H., Hattori, H., Sofia, R.D., Wichmann, J.K. Neurology (1993) [Pubmed]
  13. Newer anticonvulsant drugs: role of pharmacology, drug interactions and adverse reactions in drug choice. Natsch, S., Hekster, Y.A., Keyser, A., Deckers, C.L., Meinardi, H., Renier, W.O. Drug safety : an international journal of medical toxicology and drug experience. (1997) [Pubmed]
  14. Evidence for anticonvulsant and neuroprotectant action of felbamate mediated by strychnine-insensitive glycine receptors. McCabe, R.T., Wasterlain, C.G., Kucharczyk, N., Sofia, R.D., Vogel, J.R. J. Pharmacol. Exp. Ther. (1993) [Pubmed]
  15. A comparative review of the adverse effects of anticonvulsants in children with epilepsy. Wallace, S.J. Drug safety : an international journal of medical toxicology and drug experience. (1996) [Pubmed]
  16. Neuroprotective effect of felbamate after kainic acid-induced status epilepticus. Chronopoulos, A., Stafstrom, C., Thurber, S., Hyde, P., Mikati, M., Holmes, G.L. Epilepsia (1993) [Pubmed]
  17. Effects of felbamate on the pharmacokinetics of a low-dose combination oral contraceptive. Saano, V., Glue, P., Banfield, C.R., Reidenberg, P., Colucci, R.D., Meehan, J.W., Haring, P., Radwanski, E., Nomeir, A., Lin, C.C. Clin. Pharmacol. Ther. (1995) [Pubmed]
  18. Practice advisory: The use of felbamate in the treatment of patients with intractable epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. French, J., Smith, M., Faught, E., Brown, L. Neurology (1999) [Pubmed]
  19. Felbamate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in epilepsy. Palmer, K.J., McTavish, D. Drugs (1993) [Pubmed]
  20. Felbamate decreases synaptic transmission in the CA1 region of rat hippocampal slices. Pugliese, A.M., Passani, M.B., Pepeu, G., Corradetti, R. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  21. Felbamate block of the N-methyl-D-aspartate receptor. Subramaniam, S., Rho, J.M., Penix, L., Donevan, S.D., Fielding, R.P., Rogawski, M.A. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  22. Blood-brain barrier penetration of felbamate. Cornford, E.M., Young, D., Paxton, J.W., Sofia, R.D. Epilepsia (1992) [Pubmed]
  23. Place of newer antiepileptic drugs in the treatment of epilepsy. Kälviäinen, R., Keränen, T., Riekkinen, P.J. Drugs (1993) [Pubmed]
  24. Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation. Glue, P., Banfield, C.R., Perhach, J.L., Mather, G.G., Racha, J.K., Levy, R.H. Clinical pharmacokinetics. (1997) [Pubmed]
  25. Felbamate in experimental model of status epilepticus. Mazarati, A.M., Baldwin, R.A., Sofia, R.D., Wasterain, C.G. Epilepsia (2000) [Pubmed]
  26. A mechanistic approach to antiepileptic drug interactions. Anderson, G.D. The Annals of pharmacotherapy. (1998) [Pubmed]
  27. Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Harty, T.P., Rogawski, M.A. Epilepsy Res. (2000) [Pubmed]
  28. Idiosyncratic reactions: new methods of identifying high-risk patients. Glauser, T.A. Epilepsia (2000) [Pubmed]
  29. Role of glutathione S-transferases A1-1, M1-1, and P1-1 in the detoxification of 2-phenylpropenal, a reactive felbamate metabolite. Dieckhaus, C.M., Roller, S.G., Santos, W.L., Sofia, R.D., Macdonald, T.L. Chem. Res. Toxicol. (2001) [Pubmed]
  30. Effects of felbamate on the pharmacokinetics of the monohydroxy and dihydroxy metabolites of oxcarbazepine. Hulsman, J.A., Rentmeester, T.W., Banfield, C.R., Reidenberg, P., Colucci, R.D., Meehan, J.W., Radwanski, E., Mojaverian, P., Lin, C.C., Nezamis, J. Clin. Pharmacol. Ther. (1995) [Pubmed]
  31. Rectal administration of felbamate in a child with Lennox-Gastaut syndrome. Grossmann, R., Maytal, J., Fernando, J. Neurology (1994) [Pubmed]
  32. Felbamate measured in serum by two methods: HPLC and capillary electrophoresis. Shihabi, Z.K., Oles, K.S. Clin. Chem. (1994) [Pubmed]
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