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Gene Review

CARD17  -  caspase recruitment domain family, member 17

Homo sapiens

Synonyms: Caspase recruitment domain-containing protein 17, Caspase-1 inhibitor INCA, INCA, Inhibitory caspase recruitment domain protein
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Disease relevance of INCA


High impact information on INCA

  • Several inhibitors of NFAT-calcineurin association (INCA compounds) prevent binding of NFAT or the peptide ligand PVIVIT to calcineurin [5].
  • The spatial arrangement of the binding sites for PVIVIT and INCA makes it probable that the change in conformation involves the beta11-beta12 loop of calcineurin [5].
  • The INCA gene is located on chromosome 11q22 between the genes of COP/Pseudo-ICE and ICEBERG, two other CARD proteins that arose from caspase-1 gene duplications [6].
  • Unlike COP/Pseudo-ICE and procaspase-1, INCA does not interact with RIP2 and does not induce NF-kappaB activation [6].
  • INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation [6].

Biological context of INCA

  • Using in silico methods for screening the human genome for new caspase recruitment domain (CARD) proteins, we have identified INCA (Inhibitory CARD) as a protein that shares 81% identity with the prodomain of caspase-1 [6].
  • SUMMARY: INteractive Codon usage Analysis (INCA) provides an array of features useful in analysis of synonymous codon usage in whole genomes [7].
  • For the majority of factors, the sensitivity of the INCA appears to be approximately one order of magnitude better than that of the activated partial thromboplastin time [8].
  • The intrinsic coagulation activity assay (INCA) is a new thrombin-generation test that imitates the intrinsic pathway of blood coagulation [8].
  • With the INCA the normal range of intrinsic hemostasis is reflected, low-molecular-weight heparins can be monitored, the plasma matrix is not changed significantly, and the assay results are a percentage of normal generated thrombin activity and not coagulation seconds [9].

Anatomical context of INCA

  • INCA is specifically upregulated by interferon-gamma in the monocytic cell lines THP-1 and U937 [6].
  • INCA physically interacts with procaspase-1 and blocks the release of mature IL-1beta from LPS-stimulated macrophages [6].
  • We then examined randomly chosen files of 130 patients with angiographically normal coronary arteries, 130 patients with INCA, and 130 patients with significant coronary artery disease, in relation to the use of lipid-lowering medications and achieved lipoprotein levels [4].
  • The INCA and activated partial thromboplastin time determination were performed with factor-depleted plasmas and with mixtures of depleted plasmas with normal plasma [8].

Associations of INCA with chemical compounds

  • The dynamic model INCA (Integrated Nitrogen in Catchments) has been applied to simulate the day-to-day transport of N from the terrestrial ecosystem to the riverine environment [10].
  • The evolution over time of the nitrate fate factor as well as the steady state fate factor for each catchment scenario was obtained using the INCA simulation model [11].
  • A target low-density lipoprotein (LDL) cholesterol of < 100 mg/dl was considered appropriate for significant disease by 85% of physicians compared with 40% for INCA (p<0.0001) [4].
  • Background: INCA (Intelligent Control Assistant for Diabetes) is a project funded by the EU with the objective to improve diabetes therapy by creating a personal closed loop system interacting with telemedical remote control [12].
  • To determine the antinociceptive mechanism of incarvillateine (INCA), the opiate antagonists nor-binaltorphimine (nor-BNI), beta-funaltrexamine (beta-FNA) and naltrindole (NTI) were pretreated prior to its injection in a formalin test [13].

Analytical, diagnostic and therapeutic context of INCA


  1. Prospective study on the relationship between cervical neoplasia and herpes simplex type-2 virus. I. Epidemiological characteristics. Vonka, V., Kanka, J., Jelínek, J., Subrt, I., Suchánek, A., Havránková, A., Váchal, M., Hirsch, I., Domorázková, E., Závadová, H. Int. J. Cancer (1984) [Pubmed]
  2. Epitope mapping of the human papillomavirus type 16 E4 protein by means of synthetic peptides. Suchánková, A., Krchnák, V., Vágner, J., Hamsíková, E., Krcmár, M., Ritterová, L., Vonka, V. J. Gen. Virol. (1992) [Pubmed]
  3. Dynamic intensity-modulated non-coplanar arc radiotherapy (INCA) for head and neck cancer. Krayenbuehl, J., Davis, J.B., Ciernik, I.F. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2006) [Pubmed]
  4. Preventive therapy in patients with insignificantly narrowed coronary arteries: evaluation of physician attitude and practice. Henkin, Y., Abuful, A., Yosefi, C., Elis, A., Ilia, R., Gidron, Y. Clinical cardiology. (2004) [Pubmed]
  5. Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. Kang, S., Li, H., Rao, A., Hogan, P.G. J. Biol. Chem. (2005) [Pubmed]
  6. INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. Lamkanfi, M., Denecker, G., Kalai, M., D'hondt, K., Meeus, A., Declercq, W., Saelens, X., Vandenabeele, P. J. Biol. Chem. (2004) [Pubmed]
  7. INCA: synonymous codon usage analysis and clustering by means of self-organizing map. Supek, F., Vlahovicek, K. Bioinformatics (2004) [Pubmed]
  8. Influence of coagulation factors on intrinsic thrombin generation. Stief, T.W., Otto, S., Renz, H. Blood Coagul. Fibrinolysis (2007) [Pubmed]
  9. The intrinsic coagulation activity assay. Stief, T.W., Otto, S., Renz, H. Blood Coagul. Fibrinolysis (2006) [Pubmed]
  10. Steady state and dynamic modelling of nitrogen in the River Kennet: impacts of land use change since the 1930s. Whitehead, P.G., Johnes, P.J., Butterfield, D. Sci. Total Environ. (2002) [Pubmed]
  11. Spatialised fate factors for nitrate in catchments: modelling approach and implication for LCA results. Basset-Mens, C., Anibar, L., Durand, P., van der Werf, H.M. Sci. Total Environ. (2006) [Pubmed]
  12. Simulation based cost-benefit analysis of a telemedical system for closed-loop insulin pump therapy of diabetes. Bott, O.J., Hoffmann, I., Bergmann, J., Kosche, P., von Ahn, C., Mattfeld, D.C., Schnell, O., Pretschner, D.P. Studies in health technology and informatics (2006) [Pubmed]
  13. Pharmacological study on the novel antinociceptive agent, a novel monoterpene alkaloid from Incarvillea sinensis. Chi, Y.M., Nakamura, M., Yoshizawa, T., Zhao, X.Y., Yan, W.M., Hashimoto, F., Kinjo, J., Nohara, T., Sakurada, S. Biol. Pharm. Bull. (2005) [Pubmed]
  14. A randomized psychosocial intervention study on the effect of home visits on the well-being of Danish colorectal cancer patients--the INCA Project. Ross, L., Thomsen, B.L., Karlsen, R.V., Boesen, E.H., Johansen, C. Psycho-oncology. (2005) [Pubmed]
  15. Hospital visitors as controls in case-control studies. Mendonça, G.A., Eluf-Neto, J. Revista de saúde pública. (2001) [Pubmed]
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