Disease relevance of KCTD12

• Western blotting and real-time PCR showed that pfetin expression and tumor metastasis were inversely related [1].

High impact information on KCTD12

• Analysis of product versus time data yielded second-order reaction rate constants between the PFET reagent, tris(2,2'-bipyridine)osmium, and standards ((ferrocenylmethyl)trimethylammonium cation and p-hydroquinone) or catechols (dopamine, epinephrine, norepinephrine, 3, 4-dihydroxyphenylacetic acid [2].
• Pfet1 maps to mouse chromosome 14 near the markers D14Mit8, D14Mit93, and D14Mit145 [3].
• PFET1 maps to the long arm of human chromosome 13, in band q21 as shown by FISH analysis and STS mapping [3].
• Both genes have unusually long 3' untranslated (3' UTR) regions (4996 bp in human PFET1, 3700 bp in mouse Pfet1) containing 12 and 5 putative polyadenylation consensus sequences, respectively [3].
• Pfetin, the protein encoded by PFET1/Pfet1, is predicted to have 325 amino acids in human and 327 amino acids in mouse and to contain a voltage-gated potassium (K+) channel tetramerization (T1) domain [3].

Biological context of KCTD12

• PFET1/Pfet1 encode a single transcript of approximately 6 kb in human, and three transcripts of approximately 4, 4.5, and 6 kb in mouse with a 70% GC-rich open reading frame (ORF) consisting of 978 bp in human and 984 bp in mouse [3].

References